CAS 443642-29-3

7-Deaza-2′-C-methyladenosine

Description:

7-Deaza-2′-C-methyladenosine is a modified nucleoside that is structurally related to adenosine, featuring a 7-deaza substitution at the purine ring and a methyl group at the 2′ position of the ribose sugar. This modification enhances its stability and can influence its biological activity, making it of interest in various biochemical and pharmaceutical applications. The absence of the nitrogen atom at the 7-position of the purine ring alters the hydrogen bonding capabilities, which can affect its interaction with nucleic acids and proteins. The 2′-C-methyl group contributes to increased resistance to enzymatic degradation, making it a valuable tool in RNA research and therapeutic development. This compound is often utilized in studies involving RNA modifications, as well as in the design of nucleoside analogs for antiviral and anticancer therapies. Its unique characteristics allow for potential applications in the fields of molecular biology, medicinal chemistry, and drug design, where understanding nucleoside behavior is crucial for developing effective treatments.

Formula: C₁₂H₁₆N₄O₄

InChI: InChI=1S/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/m1/s1

InChI key: InChIKey=IRZRJANZDIOOIF-GAJNKVMBSA-N

SMILES: C[C@]1(O)[C@@H](O[C@H](CO)[C@H]1O)N2C=3C(C=C2)=C(N)N=CN3

Synonyms:

• 7-(2-C-Methyl-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• 7-Deaza-2'-C-methyladenosine
• 7H-Pyrrolo(2,3-d)pyrimidin-4-amine, 7-(2-C-methyl-beta-D-ribofuranosyl)-
• 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-C-methyl-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-
• Lamevudine
• Mk 0608
• 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-C-methyl-β-D-ribofuranosyl)-
• 7-(2-C-Methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

MK-0608

CAS: 443642-29-3

MK-0608 is an orally bioavailable HCV replication inhibitor in vitro(EC50 = 0.3 μM and EC90=1.3 μM in the subgenomic-replicon assay).

Formula: C₁₂H₁₆N₄O₄

Purity: 98.48%

Color and Shape: Solid

Molecular weight: 280.28

Ref: TM-T16088

Lamevudine

CAS: 443642-29-3

Formula: C₁₂H₁₆N₄O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 280.2798

Ref: IN-DA00DA49

7-Deaza-2''-C-methyladenosine

CAS: 443642-29-3

Formula: C₁₂H₁₆N₄O₄

Purity: (HPLC) ≥ 97.0%

Color and Shape: Off-white to light brown powder

Molecular weight: 280.29

Ref: 7W-GN6809

MK-0608

CAS: 443642-29-3

MK-0608

Formula: C₁₂H₁₆N₄O₄

Purity: ≥98%

Molecular weight: 280.28

Ref: 54-BUP05481

Mk-0608

CAS: 443642-29-3

Mk-0608

Formula: C₁₂H₁₆N₄O₄

Purity: ≥98%

Molecular weight: 280.28

Ref: 54-OR1023866

7-Deaza-2'-C-methyladenosine

CAS: 443642-29-3

7-Deaza-2'-C-methyladenosine (7DMA) is an antiviral agent that has shown anti-Hepatitis C virus activity in vitro. 7DMA inhibits the binding of a number of compounds to the viral RNA polymerase and blocks mRNA synthesis, leading to inhibition of viral replication. This drug also binds to the Toll-like receptor 3, which is involved in the immune response against hepatitis. 7DMA has been shown to have a pharmacokinetic profile suitable for use as an antiviral agent. However, it does not show any significant pharmacokinetic properties in vivo and needs further study.

Formula: C₁₂H₁₆N₄O₄

Purity: Min. 97.0 Area-%

Molecular weight: 280.28 g/mol

Ref: 3D-W-202771

7-Deaza-2'-C-methyladenosine

CAS: 443642-29-3

Anti-HCV agent; inhibitor of viral RNA polymerases

Formula: C₁₂H₁₆N₄O₄

Purity: Min. 95 Area-%

Color and Shape: Off-White Powder

Molecular weight: 280.29 g/mol

Ref: 3D-ND08351

MK-0608

CAS: 443642-29-3

Purity: 98%

Molecular weight: 280.284

Ref: 10-F983662

7-Deaza-2'-C-methyladenosine

Controlled Product

CAS: 443642-29-3

Formula: C₁₂H₁₆N₄O₄

Color and Shape: Neat

Molecular weight: 280.28

Ref: TR-D201650