CAS 444-29-1

1-Iodo-2-(trifluoromethyl)benzene

Description:

1-Iodo-2-(trifluoromethyl)benzene, with the CAS number 444-29-1, is an aromatic compound characterized by the presence of an iodine atom and a trifluoromethyl group (-CF3) attached to a benzene ring. This compound is typically a colorless to pale yellow liquid with a distinctive odor. It is known for its relatively high density and low solubility in water, making it more soluble in organic solvents. The presence of the trifluoromethyl group imparts unique electronic properties, enhancing its reactivity in various chemical reactions, particularly in nucleophilic substitution and electrophilic aromatic substitution. Additionally, the iodine atom can serve as a leaving group in reactions, facilitating the synthesis of other compounds. Due to its halogenated nature, 1-iodo-2-(trifluoromethyl)benzene may exhibit biological activity and is of interest in medicinal chemistry and materials science. Proper handling and storage are essential, as it may pose health and environmental risks.

Formula: C₇H₄F₃I

InChI: InChI=1/C7H4F3I/c8-7(9,10)5-3-1-2-4-6(5)11/h1-4H

InChI key: InChIKey=IGZGUYVVBABKOY-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C1=C(I)C=CC=C1

Synonyms:

• .alpha.,.alpha.,.alpha.-Trifluoro-o-iodo toluene
• 1-Iod-2-(trifluormethyl)benzol
• 1-Iodo-2-(trifluoromethyl)benzene
• 1-Trifluoromethyl-2-iodobenzene
• 2-(Trifluoromethyl)iodobenzene
• 2-Iodo-1-trifluoromethylbenzene
• 2-Iodobenzotrifluoride
• 2-Trifluoromethylphenyl iodide
• Benzene, 1-iodo-2- (trifluoromethyl)-
• NSC 88291
• Toluene, alpha,alpha,alpha-trifluoro-o-iodo-
• Toluene, α,α,α-trifluoro-o-iodo-
• alpha,alpha,alpha-Trifluoro-2-iodotoluene
• o-(Trifluoromethyl)iodobenzene
• o-Iodobenzotrifluoride
• o-Trifluoromethyliodobenzene
• α,α,α-Trifluoro-o-iodotoluene
• 2-(Trifluoromethyl)iodobenzene, 2-Iodo-α,α,α-trifluorotoluene
• 2-Trifluoromethyliodobenzene
• 2-Iodobenztrifluoride
• 2-Iodobenzotrifluoride (stabilized with Copper chip)
• 2-IODOBENZOTRIFLUORIDE 99%
• alpha,alpha,alpha-Trifluoro-o-iodotoluene
• o-Iodo-alpha,alpha,alpha-trifluorotoluene
• 2-Iodobenzotrifluoride,99%
• 1-iodo-2-(trifluoromethyl)-benzen
• 2-IODO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE
• O-IODINE TRIFLUORO TOLUENE

2-Iodobenzotrifluoride (stabilized with Copper chip)

CAS: 444-29-1

Formula: C₇H₄F₃I

Purity: >98.0%(GC)

Color and Shape: Colorless to Light orange to Yellow clear liquid

Molecular weight: 272.01

Ref: 3B-I0383

2-Iodobenzotrifluoride, 99%

CAS: 444-29-1

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₇H₄F₃I

Purity: 99%

Color and Shape: Liquid, Clear colorless to yellow or pale green

Molecular weight: 272.01

Ref: 02-A15698

2-Iodobenzotrifluoride

CAS: 444-29-1

Formula: C₇H₄F₃I

Purity: 98%

Color and Shape: Liquid

Molecular weight: 272.0063

Ref: IN-DA0039E1

2-Iodobenzotrifluoride

CAS: 444-29-1

2-Iodobenzotrifluoride

Formula: C₇H₄F₃I

Purity: 98%

Color and Shape: colourless to light yellow liquid

Molecular weight: 272.01g/mol

Ref: 54-PC4890

2-Iodobenzotrifluoride

CAS: 444-29-1

2-Iodobenzotrifluoride is a chemical compound that inhibits protein synthesis by binding to the aryl boronic acid groups of proteins. This compound also has anti-inflammatory properties and can be used as a control agent for inflammatory diseases. 2-Iodobenzotrifluoride is soluble in hydrocarbon solvents and reacts with sodium ions to produce sodium-dependent glucose, which can be used as an energy source for cells. The trifluoromethyl group of 2-iodobenzotrifluoride binds to the amino acids serine and histidine, inhibiting their activity. It also inhibits other enzymes such as cholesteryl ester transfer protein and carbonic anhydrase, which are involved in the production of cholesterol. 2-Iodobenzotrifluoride is also able to inhibit nucleophilic groups such as cysteine thiols (SH) and glut

Formula: C₇H₄F₃I

Purity: Min. 95%

Color and Shape: Clear Liquid

Molecular weight: 272.01 g/mol

Ref: 3D-FI37781

2-Iodobenzotrifluoride

CAS: 444-29-1

Formula: C₇H₄F₃I

Purity: 98%

Color and Shape: Liquid

Molecular weight: 272.009

Ref: 10-F001194

2-Iodobenzotrifluoride

Controlled Product

CAS: 444-29-1

Applications 2-Iodobenzotrifluoride acts as a reagent in the preparation, cyclooxygenase-1 inhibitory activity, and docking studies of aminoalkoxyphenylbenzamides. Prepartion and SAR of tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors.
References Fukai, R., et al.: ChemMedChem, 6, 550 (2011); Muthukaman, N., et al.: Bioorg. Med. Chem. Lett., 27, 2594 (2017)

Formula: C₇H₄F₃I

Color and Shape: Neat

Molecular weight: 272.01

Ref: TR-I685630