CAS 444606-18-2: Dilmapimod

Description: Dilmapimod, also known by its chemical name, is a small molecule inhibitor primarily targeting p38 mitogen-activated protein kinase (MAPK). This compound is characterized by its role in modulating inflammatory responses and has been investigated for its potential therapeutic applications in various diseases, including autoimmune disorders and cancer. Dilmapimod exhibits a specific mechanism of action by inhibiting the phosphorylation of downstream targets involved in inflammatory signaling pathways. Its chemical structure includes functional groups that contribute to its binding affinity and selectivity for the p38 MAPK enzyme. The substance is typically administered in a pharmaceutical context, and its efficacy and safety profile have been evaluated in clinical trials. As with many investigational drugs, the pharmacokinetics, metabolism, and potential side effects are critical aspects of its development and use. Overall, Dilmapimod represents a significant focus in the field of medicinal chemistry, particularly in the context of developing targeted therapies for inflammatory conditions.

Formula: C₂₃H₁₉F₃N₄O₃

InChI: InChI=1S/C23H19F3N4O3/c1-12-9-13(24)5-6-15(12)20-16-7-8-19(33)30(21-17(25)3-2-4-18(21)26)22(16)29-23(28-20)27-14(10-31)11-32/h2-9,14,31-32H,10-11H2,1H3,(H,27,28,29)

InChI key: InChIKey=ORVNHOYNEHYKJG-UHFFFAOYSA-N

SMILES: O=C1C=CC=2C(=NC(=NC2N1C=3C(F)=CC=CC3F)NC(CO)CO)C=4C=CC(F)=CC4C

Synonyms:

• 8-(2,6-Difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-[(2-hydroxy-1-hydroxymethylethyl)amino]-8H-pyrido[2,3-d]pyrimidin-7-one
• Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-
• Dilmapimod
• 8-(2,6-Difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
• SB 681323

Dilmapimod

CAS: 444606-18-2

Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic …

• Formula: C₂₃H₁₉F₃N₄O₃
• Purity: 97.53%
• Color and Shape: Solid
• Molecular weight: 456.42

SB-681323

CAS: 444606-18-2

• Formula: C₂₃H₁₉F₃N₄O₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 456.4172

8-(2,6-Difluorophenyl)-2-((1,3-Dihydroxypropan-2-Yl)Amino)-4-(4-Fluoro-2-Methylphenyl)Pyrido[2,3-D]Pyrimidin-7(8H)-One

CAS: 444606-18-2

• Purity: 98%
• Molecular weight: 456.42g/mol

Dilmapimod

CAS: 444606-18-2

Dilmapimod is an inhibitor of the enzyme phosphatidylinositol-3-kinase (PI3K) that is involved in the signaling …

• Formula: C₂₃H₁₉F₃N₄O₃
• Purity: Min. 95%
• Molecular weight: 456.42 g/mol