CAS 444805-28-1: Hexadecyloxypropyl-cidofovir
Description:Hexadecyloxypropyl-cidofovir, identified by its CAS number 444805-28-1, is a synthetic derivative of cidofovir, an antiviral medication primarily used to treat cytomegalovirus infections. This compound features a hexadecyl (16-carbon) alkoxy group, which enhances its lipophilicity, potentially improving cellular uptake and bioavailability compared to its parent compound. The structure typically includes a propyl linker that connects the hexadecyl group to the cidofovir moiety, which retains the active phosphate group essential for its antiviral activity. Hexadecyloxypropyl-cidofovir is characterized by its amphiphilic nature, allowing it to interact with lipid membranes effectively. This property may facilitate its use in drug delivery systems, particularly for targeting viral infections. Additionally, the compound's stability, solubility, and pharmacokinetic profile are critical for its therapeutic efficacy. As with many antiviral agents, its mechanism of action involves the inhibition of viral DNA polymerase, thereby preventing viral replication. Further research is necessary to fully elucidate its pharmacological properties and potential clinical applications.
Formula:C27H52N3O7P
InChI:InChI=1S/C27H52N3O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-35-20-16-21-37-38(33,34)24-36-25(23-31)22-30-18-17-26(28)29-27(30)32/h17-18,25,31H,2-16,19-24H2,1H3,(H,33,34)(H2,28,29,32)/t25-/m0/s1
InChI key:InChIKey=WXJFKKQWPMNTIM-VWLOTQADSA-N
SMILES:O=C1N=C(N)C=CN1CC(OCP(=O)(O)OCCCOCCCCCCCCCCCCCCCC)CO
- Synonyms:
- Phosphonic acid, [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-, mono[3-(hexadecyloxy)propyl] ester
- Phosphonic acid, P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-, mono[3-(hexadecyloxy)propyl] ester
- CMX 001
- HDP-cidofovir
- Hexadecyloxypropyl-cidofovir
