CAS 444805-28-1

Hexadecyloxypropyl-cidofovir

Description:

Hexadecyloxypropyl-cidofovir, identified by its CAS number 444805-28-1, is a synthetic derivative of cidofovir, an antiviral medication primarily used to treat cytomegalovirus infections. This compound features a hexadecyl (16-carbon) alkoxy group, which enhances its lipophilicity, potentially improving cellular uptake and bioavailability compared to its parent compound. The structure typically includes a propyl linker that connects the hexadecyl group to the cidofovir moiety, which retains the active phosphate group essential for its antiviral activity. Hexadecyloxypropyl-cidofovir is characterized by its amphiphilic nature, allowing it to interact with lipid membranes effectively. This property may facilitate its use in drug delivery systems, particularly for targeting viral infections. Additionally, the compound's stability, solubility, and pharmacokinetic profile are critical for its therapeutic efficacy. As with many antiviral agents, its mechanism of action involves the inhibition of viral DNA polymerase, thereby preventing viral replication. Further research is necessary to fully elucidate its pharmacological properties and potential clinical applications.

Formula: C₂₇H₅₂N₃O₇P

InChI: InChI=1S/C27H52N3O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-35-20-16-21-37-38(33,34)24-36-25(23-31)22-30-18-17-26(28)29-27(30)32/h17-18,25,31H,2-16,19-24H2,1H3,(H,33,34)(H2,28,29,32)/t25-/m0/s1

InChI key: InChIKey=WXJFKKQWPMNTIM-VWLOTQADSA-N

SMILES: C([C@H](OCP(OCCCOCCCCCCCCCCCCCCCC)(=O)O)CO)N1C(=O)N=C(N)C=C1

Synonyms:

• Phosphonic acid, [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-, mono[3-(hexadecyloxy)propyl] ester
• Phosphonic acid, P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-, mono[3-(hexadecyloxy)propyl] ester
• CMX 001
• HDP-cidofovir
• Hexadecyloxypropyl-cidofovir

Brincidofovir

CAS: 444805-28-1

Formula: C₂₇H₅₂N₃O₇P

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 561.69

Ref: 7W-GP8343

Brincidofovir

CAS: 444805-28-1

Brincidofovir

Formula: C₂₇H₅₂N₃O₇P

Purity: ≥98%

Molecular weight: 561.69

Ref: 54-BUP09087

Brincidofovir

CAS: 444805-28-1

Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir.

Formula: C₂₇H₅₂N₃O₇P

Purity: 98% - 99.62%

Color and Shape: White Solid

Molecular weight: 561.69

Ref: TM-TQ0095

Brincidofovir

CAS: 444805-28-1

3-(Hexadecyloxy)propyl hydrogen ((((S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate

Formula: C₂₇H₅₂N₃O₇P

Purity: 99%

Molecular weight: 561.69

Ref: IN-DG764523

CMX 001

CAS: 444805-28-1

CMX 001 is an antiviral medication that is a prodrug of cidofovir, which is derived from nucleoside analogs with direct inhibition of viral DNA polymerase. This mechanism of action allows CMX 001 to effectively disrupt viral replication by integrating into viral DNA and halting its synthesis. Designed to target a broad range of DNA viruses, this drug offers a robust means of controlling viral infections.

Formula: C₂₇H₅₂N₃O₇P

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 561.69 g/mol

Ref: 3D-FC58349

CMX 001 - Bio-X ™

CAS: 444805-28-1

Brincidofovir is a lipid prodrug of cidofovir which is used in the treatment of smallpox infections. It is an antiviral drug and inhibits viral replication by inhibiting viral DNA polymerase and viral RNA synthesis.

Formula: C₂₇H₅₂N₃O₇P

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 561.69 g/mol

Ref: 3D-BC300054

Brincidofovir

Controlled Product

CAS: 444805-28-1

Applications Brincidofovir is an antiviral inhibitor, working against BK polymavirus replication in primary human urothelial cells. Cytostatic, cytotoxic agent.
References Tylden, G. et al.: Antimicrob. Agent. Chemother., 59, 3306 (2015); Cardile, A. et al.: Recent Patents Anti-Infect. Drug DIscov., 9, 97 (2014)

Formula: C₂₇H₅₂N₃O₇P

Color and Shape: Neat

Molecular weight: 561.69

Ref: TR-B677550