CAS 446-86-6
:Azathioprine
Description:
Azathioprine is an immunosuppressive medication primarily used to prevent organ rejection in transplant patients and to treat autoimmune diseases such as rheumatoid arthritis and Crohn's disease. Its chemical formula is C7H10N4OS, and it features a thiazole ring, which is integral to its mechanism of action. Azathioprine is a prodrug that is metabolized into 6-mercaptopurine, which interferes with nucleic acid synthesis, thereby inhibiting the proliferation of lymphocytes. This action helps to suppress the immune response. The substance is typically administered orally and is known for its potential side effects, including bone marrow suppression, gastrointestinal disturbances, and increased susceptibility to infections. Due to its immunosuppressive properties, careful monitoring of blood counts is essential during treatment. Azathioprine is classified as a hazardous substance, and appropriate precautions should be taken when handling it in a laboratory or clinical setting. Its use requires a thorough understanding of the patient's medical history and potential drug interactions.
Formula:C9H7N7O2S
InChI:InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)
InChI key:InChIKey=LMEKQMALGUDUQG-UHFFFAOYSA-N
SMILES:S(C1=C2C(N=CN2)=NC=N1)C3=C(N(=O)=O)N=CN3C
Synonyms:- 1H-Purine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-
- 6-((1-Methyl-4-Nitroimidazol-5-Yl)Thio)Purine
- 6-(1-Methyl-4-Nitroimidazol-5-Ylthio)Purine
- 6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine
- 6-(1-Methyl-4-nitromidazol-5-ylthio)purine
- 6-(Methyl-P-Nitro-5-Imidazolyl)-Thiopurine
- 6-[(1-Methyl-4-Nitro-1H-Imidazol-5-Yl)Thio]-1H-Purine
- 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine
- 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-5H-purine
- 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine
- 9H-Purine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-
- Azafor
- Azamune
- Azanin
- Azasan
- Azathioprin
- Azathioprine
- Azathioprine Crystalline
- Azathiopurine
- Azathropine
- Azatioprina
- Azoran
- Azothioprine
- Bw 57-322
- Imuran
- Imurek
- Imurel
- Muran
- Nsc 39084
- See more synonyms
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Azathioprine
CAS:Formula:C9H7N7O2SPurity:>98.0%(HPLC)(T)Color and Shape:Light yellow to Yellow to Green powder to crystalMolecular weight:277.26Azathioprine
CAS:Azathioprine is an immunosuppressive purine antimetabolite. The mechanism of action of azathioprine is as a nucleic acid synthesis inhibitor. It has shown promise in treatment of alopecia areata (autoimmune hair loss), with no difference in effectiveness between genders. This Thermo Scientific ChemiFormula:C9H7N7O2SMolecular weight:277.266-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-9H-purine
CAS:Formula:C9H7N7O2SPurity:99%Color and Shape:SolidMolecular weight:277.26Azathioprine
CAS:AzathioprineFormula:C9H7N7O2SPurity:99.5%Color and Shape:Light YellowMolecular weight:277.03819Azathioprine
CAS:Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureFormula:C9H7N7O2SColor and Shape:Light Yellow Powder ClumpyMolecular weight:277.03819Azathioprine
CAS:Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.Formula:C9H7N7O2SPurity:99.85% - >99.99%Color and Shape:Pale Yellow Crystals From 50% Aq Acetone For The Treatment Of Rheumatoid Arthritis A Known CarcinogenMolecular weight:277.263Azathioprine
CAS:Formula:C9H7N7O2SPurity:≥ 98.0% (dried basis)Color and Shape:Pale yellow to yellow-green powderMolecular weight:277.26Azathioprine
CAS:AzathioprineFormula:C9H7N7O2SPurity:99.5%Color and Shape:SolidMolecular weight:277.266-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-9H-purine
CAS:Formula:C9H7N7O2SPurity:98%Color and Shape:SolidMolecular weight:277.2626Azathioprine-d3
CAS:Controlled ProductApplications Azathioprine-d3, is the labeled analogue of Azathioprine (A803350), an immunosuppressive antimetabolite, also active as disease modifying antirheumatic drug (DMARD).
References Mitrou, P.S., et al.: Arzneim.-Forsch., 29, 483, 662 (1979), Ding, T.L., et al.: Drug. Metab. Dispos., 7, 373 (1979), Chan, G.L.C., et al.: Pharmacotherapy, 7, 165 (1987), Sandborn, W.J., et al.: : Scand. J. Gastroenterol., 33, Suppl. 225, 92 (1998,)Formula:C9H4D3N7O2SColor and Shape:NeatMolecular weight:280.28Azathioprine
CAS:6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-9H-purineFormula:C9H7N7O2SPurity:98%Molecular weight:277.26Azathioprine
CAS:Immunosuppressant
Formula:C9H7N7O2SPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:277.26 g/mol
