CAS 451493-31-5: 2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-methylbenzenesulfonate (1:2)

Formula: C₂₇H₂₈ClFN₆O·2C₇H₈O₃S

InChI: InChI=1S/C27H28ClFN6O.C7H8O3S/c1-5-25(36)33-23-16-20-24(30-17-31-26(20)32-19-6-7-22(29)21(28)15-19)14-18(23)8-9-27(2,3)35-12-10-34(4)11-13-35;1-6-2-4-7(5-3-6)11(8,9)10/h5-7,14-17H,1,10-13H2,2-4H3,(H,33,36)(H,30,31,32);2-5H,1H3,(H,8,9,10)

InChI key: InChIKey=YTEQVKXIDXBUOT-UHFFFAOYSA-N

SMILES: O=C(C=C)NC1=CC=2C(=NC=NC2NC3=CC=C(F)C(Cl)=C3)C=C1C#CC(N4CCN(C)CC4)(C)C.O=S(=O)(O)C1=CC=C(C=C1)C

Synonyms:

• AV 412
• 2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-6-quinazolinyl]-, bis(4-methylbenzenesulfonate)
• MP 412
• 2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-methylbenzenesulfonate (1:2)
• AV 412 tosylate

AV-412

CAS: 451493-31-5

AV-412 (MP412) is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 …

• Formula: C₄₁H₄₄ClFN₆O₇S₂
• Purity: 99.85%
• Color and Shape: Solid
• Molecular weight: 851.41

2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1

CAS: 451493-31-5

• Formula: C₄₁H₄₄ClFN₆O₇S₂
• Purity: 95%
• Molecular weight: 851.4055

2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-methyl benzenesulfonate (1:2)

CAS: 451493-31-5

N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]2,2′:6′,2″:6″,6′″-(tertiary butoxycarbonylamino)biphenyl (DG3178) is a novel small molecule that has shown the potential to inhibit …

• Formula: C₂₇H₂₈ClFN₆O·2C₇H₈O₃S
• Purity: Min. 95%
• Molecular weight: 851.42 g/mol