CAS 453562-69-1

Motesanib

Description:

Motesanib is a small molecule that functions primarily as a tyrosine kinase inhibitor, targeting various receptor tyrosine kinases involved in angiogenesis and tumor growth. It is particularly noted for its activity against vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs), and fibroblast growth factor receptors (FGFRs). Motesanib has been investigated for its potential therapeutic applications in treating various cancers, including non-small cell lung cancer and other solid tumors. The compound is characterized by its ability to inhibit tumor vascularization, thereby limiting the supply of nutrients and oxygen to tumors. In terms of its chemical structure, Motesanib features a complex arrangement that contributes to its biological activity, although specific structural details are not provided here. As with many investigational drugs, the pharmacokinetics, efficacy, and safety profile of Motesanib have been subjects of clinical studies, with varying results influencing its development in oncology.

Formula: C₂₂H₂₃N₅O

InChI: InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)

InChI key: InChIKey=RAHBGWKEPAQNFF-UHFFFAOYSA-N

SMILES: CC1(C)C=2C(=CC(NC(=O)C3=C(NCC=4C=CN=CC4)N=CC=C3)=CC2)NC1

Synonyms:

• 3-Pyridinecarboxamide, N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-
• Amg 706
• N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide
• N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide
• Motesanib

Motesanib

CAS: 453562-69-1

Formula: C₂₂H₂₃N₅O

Purity: 98%

Color and Shape: Solid

Molecular weight: 373.4509

Ref: IN-DA00D80C

Motesanib

CAS: 453562-69-1

Motesanib

Purity: ≥98%

Molecular weight: 373.45g/mol

Ref: 54-BUP14408

Motesanib

CAS: 453562-69-1

Motesanib

Formula: C₂₂H₂₃N₅O

Purity: 99%

Color and Shape: pale yellow solid

Molecular weight: 373.45g/mol

Ref: 54-BIFK0029

Motesanib

CAS: 453562-69-1

Formula: C₂₂H₂₃N₅O

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 373.46

Ref: 3B-M3717

Motesanib

CAS: 453562-69-1

Motesanib (AMG 706) orally blocks VEGFR, PDGFR, Kit, Ret; curbing angiogenesis and cancer cell growth.

Formula: C₂₂H₂₃N₅O

Purity: 98% - 99.09%

Color and Shape: Solid

Molecular weight: 373.45

Ref: TM-T2288

Motesanib

CAS: 453562-69-1

Ref: 7W-GW4075

Motesanib

CAS: 453562-69-1

Inhibitor of VEGFR, PDGR, c-Kit and Ret; inhibitor of angiogenesis

Formula: C₂₂H₂₃N₅O

Purity: Min. 95%

Molecular weight: 373.45 g/mol

Ref: 3D-FM65094

Motesanib

Controlled Product

CAS: 453562-69-1

Applications Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.
References Rosen, L., et al.: J. Clin. Oncol., 25, 2369 (2007), Sherman, S., et al.: New Engl. J. Med., 359, 31 (2008),

Formula: C₂₂H₂₃N₅O

Color and Shape: Neat

Molecular weight: 373.45

Ref: TR-M732500