CAS 458-37-7

Curcumin

Description:

Curcumin, with the CAS number 458-37-7, is a natural polyphenolic compound primarily derived from the rhizome of the turmeric plant (Curcuma longa). It is known for its vibrant yellow color and is widely recognized for its potential health benefits, including anti-inflammatory, antioxidant, and anticancer properties. Curcumin exhibits a complex chemical structure, characterized by its diketone and phenolic groups, which contribute to its reactivity and biological activity. It is poorly soluble in water but soluble in organic solvents, which can affect its bioavailability in therapeutic applications. Curcumin has been the subject of extensive research, exploring its role in various health conditions, including chronic diseases and metabolic disorders. Additionally, it has been studied for its potential use in food coloring and as a dietary supplement. However, its stability can be influenced by factors such as pH and light exposure, which are important considerations in both research and practical applications.

Formula: C₂₁H₂₀O₆

InChI: InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

InChI key: InChIKey=VFLDPWHFBUODDF-FCXRPNKRSA-N

SMILES: C(=C/C(CC(/C=C/C1=CC(OC)=C(O)C=C1)=O)=O)\C2=CC(OC)=C(O)C=C2

Synonyms:

• (1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one
• (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
• (E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
• (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione
• (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
• 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-
• 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-
• 1,7-Bis(4-Hidroxi-3-Metoxifenil)Hepta-1,6-Dieno-3,5-Diona
• 1,7-Bis(4-Hydroxy-3-Methoxyphenyl)-1,6-Heptadiene-3,5-Dione
• 1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-dien-3,5-dion
• 1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
• Biocurcumax
• Br 213
• C Yellow 15
• Colorant E 100
• Curcuma
• Curcuma yellow
• Curcumax
• Curcumin I
• Curcumin W
• Curcumine
• Cureit
• Curouma
• Diferuloylmethane
• E 100 (dye)
• E-100
• E100
• Gelbwurz
• Haidr
• Halad
• Haldar
• Halud
• Hepta-1,6-Diene-3,5-Dione, 1,7-Bis(4-Hydroxy-3-Methoxyphenyl)- (1E,6E)
• INS 100i
• Indian Saffron
• Jianghuangsu
• Kacha Haldi
• Kachs Haldi
• Kiriyasu Oil Yellow U
• Lipocurc
• Longvida
• Merita Earth
• NanoCurc
• Natural Yellow 3
• Natxtra
• Nsc 32982
• Safra D'Inde
• San-Ei Curcumine AL
• San-Ei Gen Curcumine AL
• Souchet
• Terra Merita
• Theracurmin
• Theracurmin CR 011L
• Tumeric Yellow
• Turmeric
• Turmeric (dye)
• Turmeric yellow
• Ukon
• Ukon (dye)
• Vacurin
• Yellow Ginger
• Yellow Root
• Yo-Kin
• trans,trans-Curcumin
• C.I. 75300
• C.I. 75300
• C.I. Natural Yellow 3
• Curcumin

Curcumin (Natural)

CAS: 458-37-7

Formula: C₂₁H₂₀O₆

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 368.39

Ref: 3B-C0434

Curcumin (Synthetic)

CAS: 458-37-7

Formula: C₂₁H₂₀O₆

Purity: >97.0%(T)

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 368.39

Ref: 3B-C2302

Curcumin, 95% (total curcuminoid content), from Turmeric rhizome

CAS: 458-37-7

Curcumin is used for boron quantification. It inhibits lipoxygenase and cyclooxygenase. It acts as a dietary supplement and is used in pharmaceutical industry. It acts as a food coloring agent and acts as a food additive. This Thermo Scientific Chemicals brand product was originally part of the Alfa

Formula: C₂₁H₂₀O₆

Purity: 95%

Color and Shape: Orange-yellow or orange, Powder or crystalline powder

Molecular weight: 368.39

Ref: 02-B21573

Curcumin

CAS: 458-37-7

Curcumin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₂₁H₂₀O₆

Purity: (HPLC) ≥98%

Color and Shape: Powder

Molecular weight: 368.39

Ref: 11-4739S

Curcumin

CAS: 458-37-7

Formula: [HOC6H3(OCH3)CH=CHCO]2CH2

Purity: ≥65% (HPLC)

Color and Shape: powder

Molecular weight: 368.38

Ref: 23-C1386

Curcumin

CAS: 458-37-7

Coloring matter of vegetable or animal origin

Formula: C₂₁H₂₀O₆

Color and Shape: Orange Yellow Powder

Molecular weight: 368.12599

Ref: 45-1151855

(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

CAS: 458-37-7

Formula: C₂₁H₂₀O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 368.3799

Ref: IN-DA0038PG

Curcumin

CAS: 458-37-7

Curcumin

Formula: C₂₁H₂₀O₆

Purity: 97%

Color and Shape: Solid-Powder

Molecular weight: 368.3799

Ref: 54-BIC8500

Curcumin

CAS: 458-37-7

Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity.

Formula: C₂₁H₂₀O₆

Purity: 95% - 99.91%

Color and Shape: Solid

Molecular weight: 368.38

Ref: TM-T1516

Curcumin, pure, 98%

CAS: 458-37-7

Formula: C₂₁H₂₀O₆

Purity: (HPLC) ≥ 98.0%

Color and Shape: Yellow or orange powder

Molecular weight: 368.39

Ref: 7W-GP7022

Curcumin

CAS: 458-37-7

Formula: C₂₁H₂₀O₆

Color and Shape: Orange Solid

Molecular weight: 368.39

Ref: 4Z-C-691

Curcumin

CAS: 458-37-7

Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities, it has effective activity against including cancer, cardio-

Formula: C₂₁H₂₀O₆

Purity: 95%~99%

Color and Shape: Orange powder

Molecular weight: 368.385

Ref: BP-BP0421

Curcumin (Standard)

CAS: 458-37-7

Curcumin (Standard) is a reference standard for research and analysis in studies involving Curcumin. Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant.

Formula: C₂₁H₂₀O₆

Color and Shape: Solid

Molecular weight: 368.38

Ref: TM-TMSM-2122

(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

CAS: 458-37-7

Formula: C₂₁H₂₀O₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 368.385

Ref: 10-F358294

Curcumin (0.1% in ca. 95% Ethanol)

CAS: 458-37-7

Color and Shape: Light yellow to Brown clear liquid

Ref: 3B-C0435

Curcumin

CAS: 458-37-7

Formula: C₂₁H₂₀O₆

Color and Shape: Neat

Molecular weight: 368.38

Ref: 04-C11780000

(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

CAS: 458-37-7

(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

Formula: C₂₁H₂₀O₆

Purity: 96%

Color and Shape: Orange Solid-Powder

Molecular weight: 368.3799

Ref: 54-OR24598

Curcumin

CAS: 458-37-7

Formula: C₂₁H₂₀O₆

Color and Shape: Yellow or orange powder

Molecular weight: 368.39

Ref: 7W-GP8291

Curcumin

CAS: 458-37-7

Ketone phenol

Formula: C₂₁H₂₀O₆

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 368.39

Ref: 5G-89180

Curcumin

CAS: 458-37-7

Applications A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disease. Neuroprotective. Dyes and metabolites.
References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007), Chem. and Eng. News 90(31), 44 (2012)

Formula: C₂₁H₂₀O₆

Color and Shape: Neat

Molecular weight: 368.38

Ref: TR-C838500