CAS 465-39-4

Resibufogenin

Description:

Resibufogenin is a naturally occurring compound classified as a bufadienolide, which is a type of steroidal glycoside. It is primarily derived from the skin of certain toads, particularly those in the Bufo genus. This compound exhibits a range of biological activities, including cardiotonic effects, which can influence heart function by increasing the force of contraction. Resibufogenin has also been studied for its potential anti-cancer properties, as it may induce apoptosis in various cancer cell lines. The substance is characterized by its specific molecular structure, which includes a steroid backbone with multiple hydroxyl groups and a lactone ring. Its pharmacological effects are attributed to its ability to interact with various cellular targets, including ion channels and enzymes. However, due to its potent biological activity, resibufogenin must be handled with caution, as it can exhibit toxicity at higher concentrations. Research continues to explore its therapeutic potential and mechanisms of action in various medical applications.

Formula: C₂₄H₃₂O₄

InChI: InChI=1S/C24H32O4/c1-22-9-7-16(25)11-15(22)4-5-18-17(22)8-10-23(2)19(12-20-24(18,23)28-20)14-3-6-21(26)27-13-14/h3,6,13,15-20,25H,4-5,7-12H2,1-2H3/t15-,16+,17+,18-,19-,20-,22+,23-,24-/m1/s1

InChI key: InChIKey=ATLJNLYIJOCWJE-CWMZOUAVSA-N

SMILES: C[C@]12[C@]3([C@](O3)(C[C@@H]1C=4C=CC(=O)OC4)[H])[C@]5([C@](CC2)([C@]6(C)[C@](CC5)(C[C@@H](O)CC6)[H])[H])[H]

Synonyms:

• (3Beta,5Beta,15Beta)-3-Hydroxy-14,15-Epoxybufa-20,22-Dienolide
• (3Beta,5Beta,8Xi,9Xi,15Beta)-3-Hydroxy-14,15-Epoxybufa-20,22-Dienolide
• (3β,5β,15β)-14,15-Epoxy-3-hydroxybufa-20,22-dienolide
• 14,15β-Epoxy-3β-hydroxy-5β-bufa-20,22-dienolide
• 3-Hydroxy-14,15-Epoxybufa-20,22-Dienolide
• 3β-Hydroxy-14,15β-epoxy-5β-bufa-20,22-dienolide
• 5β-Bufa-20,22-dienolide, 14,15β-epoxy-3β-hydroxy-
• Bufa-20,22-dienolide, 14,15-epoxy-3-hydroxy-, (3β,5β,15β)-
• NSC 90783
• Recibufogenin
• Resibufogenin
• Resinobufagin
• Respigon

Bufa-20,22-dienolide, 14,15-epoxy-3-hydroxy-, (3b,5b,15b)-

CAS: 465-39-4

Formula: C₂₄H₃₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 384.5085

Ref: IN-DA00I8KS

Resibufogenin

CAS: 465-39-4

Formula: C₂₄H₃₂O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 384.51

Ref: 7W-GP1238

Resibufogenin

CAS: 465-39-4

Resibufogenin

Purity: ≥98%

Molecular weight: 384.51g/mol

Ref: 54-BUP04448

Bufogenin

CAS: 465-39-4

Resibufogenin is a cytotoxic steroid isolated from the Chinese drug ChanSu, which exhibits the anti-proliferative effect against cancer cells through the degradation of cyclin D1 caused by the activation of GSK-3β. Resibufogenin can inhibit rectifier potassium current ( I K ) and transient potassium current ( I A ), it has pathological effects on central nervous system. Resibufogenin corrects hypertension in a rat model of human preeclampsia, it not only prevents the advent of hypertension and proteinuria, but also the development of intrauterine growth restriction.

Formula: C₂₄H₃₂O₄

Purity: 95%~99%

Molecular weight: 384.516

Ref: BP-BP0289

Resibufogenin

CAS: 465-39-4

Resibufogenin, a cytotoxic steroid from ChanSu, affects CNS and potassium currents; treats rat preeclampsia; metabolized by CYP3A4 in liver.

Formula: C₂₄H₃₂O₄

Purity: 98.78% - 99.17%

Color and Shape: White To Off-White Solid

Molecular weight: 384.51

Ref: TM-T4A2458

Resibufogenin

CAS: 465-39-4

Lactone

Formula: C₂₄H₃₂O₄

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 384.52

Ref: 5G-89774

Resibufogenin

CAS: 465-39-4

Resibufogenin is a cardiotonic steroid, which is a natural compound derived from the skin of toads, particularly from the genus Bufo. It is a member of the bufadienolide class of compounds, known for their potent inotropic activities due to their ability to inhibit Na⁺/K⁺-ATPase. This inhibition leads to an increase in intracellular sodium concentrations, which indirectly causes an increase in intracellular calcium through the sodium-calcium exchanger, ultimately enhancing cardiac contractility.

Formula: C₂₄H₃₂O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 384.51 g/mol

Ref: 3D-FR41649

Resibufogenin

Controlled Product

CAS: 465-39-4

Formula: C₂₄H₃₂O₄

Color and Shape: Neat

Molecular weight: 384.51

Ref: TR-R144660