CAS 470-37-1

Cinobufagin

Description:

Cinobufagin is a naturally occurring compound classified as a bufadienolide, which is a type of steroidal glycoside. It is primarily derived from the skin of certain toads, particularly those in the Bufo genus. This compound exhibits a range of biological activities, including cardiotonic effects, which can influence heart muscle contractions. Cinobufagin has been studied for its potential therapeutic applications, particularly in traditional medicine, where it is believed to possess anti-cancer, anti-inflammatory, and immunomodulatory properties. The substance is characterized by its complex molecular structure, which includes a steroid backbone and specific functional groups that contribute to its biological activity. However, due to its potent effects, cinobufagin can also exhibit toxicity, necessitating careful consideration in its use. Research continues to explore its mechanisms of action and potential clinical applications, while also addressing safety and efficacy concerns. As with many natural compounds, the pharmacological profile of cinobufagin is of significant interest in both traditional and modern medicinal contexts.

Formula: C₂₆H₃₄O₆

InChI: InChI=1S/C26H34O6/c1-14(27)31-22-21(15-4-7-20(29)30-13-15)25(3)11-9-18-19(26(25)23(22)32-26)6-5-16-12-17(28)8-10-24(16,18)2/h4,7,13,16-19,21-23,28H,5-6,8-12H2,1-3H3/t16-,17+,18+,19-,21+,22-,23-,24+,25-,26-/m1/s1

InChI key: InChIKey=SCULJPGYOQQXTK-OLRINKBESA-N

SMILES: C[C@]12[C@]3([C@](O3)([C@H](OC(C)=O)[C@@H]1C=4C=CC(=O)OC4)[H])[C@]5([C@](CC2)([C@]6(C)[C@](CC5)(C[C@@H](O)CC6)[H])[H])[H]

Synonyms:

• (3Beta,5Beta,15Beta,16Beta)-16-(Acetyloxy)-3-Hydroxy-14,15-Epoxybufa-20,22-Dienolide
• (3beta,5beta,8xi,9xi,10xi,13xi,14beta,15beta,16beta,17beta)-3-hydroxy-17-(2-oxo-2H-pyran-4-yl)-14,15-epoxyandrostan-16-yl acetate
• (3β,5β,15β,16β)-16-(Acetyloxy)-14,15-epoxy-3-hydroxybufa-20,22-dienolide
• 14,15-Epoxy-14H-cyclopenta[a]phenanthrene, bufa-20,22-dienolide deriv.
• 5β-Bufa-20,22-dienolide, 14,15β-epoxy-3β,16β-dihydroxy-, 16-acetate
• Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3-hydroxy-, (3β,5β,15β,16β)-
• Cinobufagenin
• Cinobufagin
• Cinobufagine
• Cinobufogenin
• NSC 90325

Cinobufagine

CAS: 470-37-1

Formula: C₂₆H₃₄O₆

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 442.55

Ref: 3B-C3460

Cinobufagin

CAS: 470-37-1

Cinobufagin

Formula: C₂₆H₃₄O₆

Purity: ≥95%

Molecular weight: 442.54

Ref: 54-BUP07390

Cinobufagin

CAS: 470-37-1

Formula: C₂₆H₃₄O₆

Purity: ≥ 98.0%

Color and Shape: White or off-white powder

Molecular weight: 442.54

Ref: 7W-GP7595

Cinobufagin

CAS: 470-37-1

Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer, it also has anti-hepatitis B virus activity . Cinobufagin inhibits the proliferation and induces apoptosis, may be related to the mitochondria-mediated pathway and GSK-3β/NF-κB pathway. Cinobufagin can significantly relieve cancer pain in mice and raised their pain threshold, mainly upregulating the expression levels of β -END and μ -OR in the hind paw tumor and adjacent tissue.Cinobufagin and bufalin exhibit cardiotonic and natriuretic activities, they also have inhibitory effects on steroidogenesis of aldosterone and cortisol.

Formula: C₂₆H₃₄O₆

Purity: 95%~99%

Molecular weight: 442.552

Ref: BP-BP0366

Cinobufagin

CAS: 470-37-1

Cinobufagin (Cinobufagine) is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain.

Formula: C₂₆H₃₄O₆

Purity: 97.77% - 99.97%

Color and Shape: Solid

Molecular weight: 442.54

Ref: TM-T3432

Cinobufagin

CAS: 470-37-1

Lactone

Formula: C₂₆H₃₄O₆

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 442.55

Ref: 5G-89609

Cinobufagine-d3

Controlled Product

CAS: 470-37-1

Applications Isotope labelled Cinobufagine (C475500) is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yin, J.Q., et al.: Toxicol. Lett., 218, 129 (2013); Xing, J.F., et al.: J. Separat. Sci., 35, 1884 (2012);

Formula: C₂₆H₃₁D₃O₆

Color and Shape: Neat

Molecular weight: 445.56

Ref: TR-C475502

Cinobufagin

CAS: 470-37-1

Cinobufagin is a bufadienolide compound, which is a type of steroid. It is sourced from the venom of the Chinese toad, Bufo bufo gargarizans, commonly used in traditional Chinese medicine. The compound exerts its effects primarily through the modulation of cellular signaling pathways, such as inhibiting the Na+/K+-ATPase pump, which leads to alterations in ion gradients and subsequent induction of apoptosis in cancer cells.

Formula: C₂₆H₃₄O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 442.54 g/mol

Ref: 3D-FC65673

Cinobufagin - Bio-X ™

CAS: 470-37-1

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₆H₃₄O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 442.54 g/mol

Ref: 3D-BC300057

Cinobufagine

Controlled Product

CAS: 470-37-1

Applications Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yin, J.Q., et al.: Toxicol. Lett., 218, 129 (2013); Xing, J.F., et al.: J. Separat. Sci., 35, 1884 (2012);

Formula: C₂₆H₃₄O₆

Color and Shape: Neat

Molecular weight: 442.54

Ref: TR-C475500