CAS 471-53-4

Glycyrrhetinic acid

Description:

Glycyrrhetinic acid is a triterpenoid compound derived from the root of the licorice plant, Glycyrrhiza glabra. It is known for its sweet flavor and is often used in traditional medicine for its anti-inflammatory, antiviral, and hepatoprotective properties. The chemical structure of glycyrrhetinic acid features a pentacyclic triterpene framework, which contributes to its biological activity. It is typically found as a white to off-white crystalline powder and is soluble in organic solvents like ethanol and methanol, but has limited solubility in water. Glycyrrhetinic acid is recognized for its ability to inhibit the enzyme 11β-hydroxysteroid dehydrogenase type 2, which can lead to increased cortisol levels in the body. This property has implications for its use in treating conditions related to adrenal insufficiency and other hormonal imbalances. Additionally, it has been studied for its potential effects on skin health and its role in modulating immune responses. However, excessive consumption can lead to side effects, including hypertension and hypokalemia, due to its mineralocorticoid-like effects.

Formula: C₃₀H₄₆O₄

InChI: InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1

InChI key: InChIKey=MPDGHEJMBKOTSU-YKLVYJNSSA-N

SMILES: C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](O)CC3)[H])(C(=O)C=C4[C@@]2(C)CC[C@]5(C)[C@]4(C[C@](C(O)=O)(C)CC5)[H])[H]

Synonyms:

• Enoxolone
• 18beta-Glycyrrhetinic acid
• 18B-glycyrrhetinic acid
• Glycyrrheticacid
• Glycyrrhetic acid
• 18-Beta-Glycyrrheticacid
• 3.beta.-Hydroxy-11-oxo-12-oleanen-30-oicacid
• 3-Beta-Hydroxy-11-Oxo-Olean-12-En-30-Oicaci
• 3-Beta-Hydroxy-11-Oxoolean-12-En-30-Oicacid
• 3-hydroxy-11-oxo-,(3.beta.,20.beta.)-Olean-12-en-29-oicacid
• 3-Hydroxy-11-Oxo-,(3Beta,20Beta)-Olean-12-En-29-Oicaci
• 3-Hydroxy-11-oxo-12-oleanen-30-oicacid
• Alpha-Glycyrrhetinicacid
• Glycyrrhetinic acid
• (3Beta,5Xi,9Xi)-3-Hydroxy-11-Oxoolean-12-En-30-Oic Acid
• 18-Β-Glycyrrhetinic Acid
• (3β,20β)-3-Hydroxy-11-oxoolean-12-en-29-oic acid
• 18β-Glycyrrhetic acid
• Arthrodont
• Biosone
• Enoxolon
• Enoxolona
• Glycyrrhetin
• Glycyrrhetinsaeure
• Gm 1658
• Nsc 35347
• Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-
• Olean-12-en-30-oic acid, 3β-hydroxy-11-oxo-
• Po 12
• Stx 352
• Subglycyrrhelinic acid
• Uralenic acid

Glycyrrhetic Acid

CAS: 471-53-4

Formula: C₃₀H₄₆O₄

Purity: >97.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 470.69

Ref: 3B-G0149

18-β-Glycyrrhetinic acid

CAS: 471-53-4

18-beta-Glycyrrhetinic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₃₀H₄₆O₄

Purity: (HPLC) ≥99%

Color and Shape: Powder

Molecular weight: 470.7

Ref: 11-0043S

ENOXOLONE CRS

CAS: 471-53-4

ENOXOLONE CRS

Formula: C₃₀H₄₆O₄

Molecular weight: 470.6838

Ref: 41-E0180500

ENOXOLONE FOR PEAK IDENTIFICATION CRS

CAS: 471-53-4

ENOXOLONE FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0002340

18β-Glycyrrhetinic acid

CAS: 471-53-4

18β-Glycyrrhetinic acid (Enoxolone) is the major bioactive component of Glycyrrhizae Radix and possesses anti-inflammatory and antiproliferative properties.

Formula: C₃₀H₄₆O₄

Purity: 99.03% - 99.64%

Color and Shape: Solid

Molecular weight: 470.68

Ref: TM-T0036

Glycyrrhetinic acid

CAS: 471-53-4

Formula: C₃₀H₄₆O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 470.6838

Ref: IN-DA00I8M3

Enoxolone

CAS: 471-53-4

Formula: C₃₀H₄₆O₄

Purity: ≤ 0.7%

Color and Shape: White or almost white crystalline powder

Molecular weight: 470.68

Ref: 7W-GP8041

18β-Glycyrrhetinic acid

CAS: 471-53-4

18β-Glycyrrhetinic acid

Purity: ≥98%

Molecular weight: 470.68g/mol

Ref: 54-BUP18306

Glycyrrhetic Acid (Enoxolone)

CAS: 471-53-4

Formula: C₃₀H₄₆O₄

Molecular weight: 470.69

Ref: 4Z-G-060001

Glycyrrhetic Acid-d3

CAS: 471-53-4

Formula: C₃₀H₄₃D₃O₄

Color and Shape: Pale Yellow Solid

Molecular weight: 473.71

Ref: 4Z-G-060006

Enoxolone

Controlled Product

CAS: 471-53-4

Formula: C₃₀H₄₆O₄

Color and Shape: Neat

Molecular weight: 470.68

Ref: 86-MM3399.00

Enoxolone

Controlled Product

CAS: 471-53-4

Formula: C₃₀H₄₆O₄

Color and Shape: Neat

Molecular weight: 470.68

Ref: 04-C13167700

18β-Glycyrrhetinic acid

CAS: 471-53-4

Glycyrrhetinic acid, a hydrolysis product of one of the main constituents of licorice, the triterpene glycoside of glycyrrhizic acid, when added to rat liver mitochondria at micromolar concentrations induces swelling, loss of membrane potential, pyridine nucleotide oxidation, and release of cytochrome c and apoptosis inducing factor; indicates that glycyrrhetinic acid is a potent inducer of mitochondrial permeability transition and can trigger the pro-apoptotic pathway.

Formula: C₃₀H₄₆O₄

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 470.694

Ref: BP-BP0681

Enoxolone 100 µg/mL in Acetonitrile

CAS: 471-53-4

Formula: C₃₀H₄₆O₄

Color and Shape: Single Solution

Molecular weight: 470.68

Ref: 04-A13167700AL-100

18β-glycyrrhetinic acid

CAS: 471-53-4

Carboxylic acid with additional oxygen functions

Formula: C₃₀H₄₆O₄

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 470.7

Ref: 5G-89694

Glycyrrhetic Acid

Controlled Product

CAS: 471-53-4

Formula: C₃₀H₄₆O₄

Color and Shape: White

Molecular weight: 470.68

Ref: TR-G735000

Glycyrrhetinic acid

Controlled Product

CAS: 471-53-4

Glycyrrhetinic acid is the aglycone form of the triterpenoid glycyrrhizin that is naturally found in licorice root. In vitro studies have evidenced the anti‐inflammatory, antioxidant and antibacterial activites of glycyrrhetinic acid (Loizzo, 2013). In in vitro cell models and mice models of inflammatory conditions, glycyrrhetinic acid inhibited the release of interleukins and the tumor necrosis factor (TNF)-alpha while showing a hepatoprotective effect (Yu , 2015).

Formula: C₃₀H₄₆O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 470.68 g/mol

Ref: 3D-FG09301