CAS 474-25-9

Chenodeoxycholic acid

Description:

Chenodeoxycholic acid (CDCA) is a bile acid that plays a crucial role in the digestion and absorption of dietary fats and fat-soluble vitamins in the intestine. It is a white to off-white crystalline powder that is soluble in water and organic solvents like ethanol and methanol. CDCA is synthesized in the liver from cholesterol and is a primary bile acid, meaning it is produced directly from cholesterol rather than being derived from other bile acids. Its chemical structure features a steroid nucleus with hydroxyl groups at specific positions, contributing to its amphipathic nature, which allows it to emulsify fats. CDCA is involved in the regulation of cholesterol metabolism and has been studied for its therapeutic potential in conditions such as gallstones and certain liver diseases. Additionally, it can influence the gut microbiome and has implications in metabolic health. As a naturally occurring substance, it is also used in various pharmaceutical formulations and dietary supplements.

Formula: C₂₄H₄₀O₄

InChI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1

InChI key: InChIKey=RUDATBOHQWOJDD-BSWAIDMHSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@H]3O)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]

Synonyms:

• (3Alpha,5Beta,7Alpha,8Xi,9Xi,14Xi)-3,7-Dihydroxycholan-24-Oic Acid
• (3Alpha,5Beta,7Alpha,8Xi,9Xi,14Xi)-3,7-Dihydroxycholan-24-Oicacid
• (3α,5β,7α)-3,7 Dihydroxycholan-24-oic acid
• (5Beta)-3,7-Dihydroxycholan-24-Oic Acid
• (5Beta)-3,7-Dihydroxycholan-24-Oicacid
• 17β-(1-Methyl-3-carboxypropyl)etiocholane-3α,7α-diol
• 3-Alpha,7-Alpha-Dihydroxy-5-Beta-Cholan-24-Oicacid
• 3alpha,7alpha-Dihydroxy-5beta-cholanic acid
• 3α,7α-Dihydroxy-5β-cholan-24-oic acid
• 3α,7α-Dihydroxy-5β-cholanic acid
• 3α,7α-Dihydroxy-5β-cholanoic acid
• 3α,7α-Dihydroxycholanic acid
• 5β-Cholan-24-oic acid, 3α,7α-dihydroxy-
• 5β-Cholanic acid, 3α,7α-dihydroxy-
• 7α-Hydroxylithocholic acid
• Acide chenodesoxycholique
• Acido Chenodeoxicholico
• Anthropodeoxycholic acid
• Anthropodesoxycholic acid
• Anthropododesoxycholic acid
• CDC
• CHOLANIC ACID, 3-α, 7-α-DIHYDROXY-5-β-
• Cdca
• Chendeoxycholicacid
• Chendol
• Chenic acid
• Chenix
• Chenocedon
• Chenocol
• Chenodeoxcholic acid
• Chenodesoxycholic acid
• Chenodesoxycholsaure
• Chenodex
• Chenodiol
• Chenofalk
• Chenossil
• Cholan-24-oic acid, 3,7-dihydroxy-, (3α,5β,7α)-
• Cholanorm
• Fluibil
• Gallodesoxycholic acid
• Hekbilin
• Kebilis

Chenodeoxycholic acid

Controlled Product

CAS: 474-25-9

Chenodeoxycholic acid is a human primary bile acid which is also found the bile of geese. Its C-7 epimer, Ursodeoxycholic acid is found in bear’s bile. Both bile acids are used for the treatment of gallstones, although Ursodeoxycholic acid has shown superior efficacy (bear’s bile extracts are also used in Chinese medicine).

Formula: C₂₄H₄₀O₄

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 392.57 g/mol

Ref: 3D-FC09675

Chenodeoxycholic Acid

CAS: 474-25-9

Formula: C₂₄H₄₀O₄

Color and Shape: Solid

Molecular weight: 392.6

Ref: BE-MU-1004

Chenodeoxycholic Acid-[d9] in Methanol

CAS: 474-25-9

Methanol

Formula: C₂₄H₄₀O₄

Color and Shape: Solid

Molecular weight: 392.6

Ref: BE-MD-1004D9XM-100

Chenodeoxycholic Acid-[13C3] in Methanol

CAS: 474-25-9

Methanol

Formula: C₂₄H₄₀O₄

Color and Shape: Solid

Molecular weight: 392.6

Ref: BE-MC-1004XM-100

Chenodeoxycholic Acid in Methanol

CAS: 474-25-9

Methanol

Formula: C₂₄H₄₀O₄

Color and Shape: Solid

Molecular weight: 392.6

Ref: BE-MU-1004YM-1000

Chenodeoxycholic acid

CAS: 474-25-9

Formula: C₂₄H₄₀O₄

Color and Shape: Solid

Molecular weight: 392.6

Ref: BE-RMT11540

Chenodeoxycholic Acid-[d9]

CAS: 474-25-9

Formula: C₂₄H₄₀O₄

Color and Shape: Solid

Molecular weight: 392.6

Ref: BE-MD-1004D9

Chenodeoxycholic acid

CAS: 474-25-9

Formula: C₂₄H₄₀O₄

Color and Shape: Solid

Molecular weight: 392.6

Ref: BE-RMCC184017

Chenodeoxycholic acid

CAS: 474-25-9

(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

Formula: C₂₄H₄₀O₄

Purity: 98+%

Molecular weight: 392.57

Ref: IN-DG764669

Chenodeoxycholic acid

CAS: 474-25-9

Formula: C₂₄H₄₀O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 392.58

Ref: 10-F218990

Chenodeoxycholic Acid-d7 (Major)

Controlled Product

CAS: 474-25-9

Applications Chenodeoxycholic Acid-d7 is a labelled analogue of Chenodeoxycholic Acid (C291900), which is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol. In addition, Chenodeoxycholic Acid-d7 is an intermediate in synthesizing Glycochenodeoxycholic Acid-d7 Sodium Salt (G641257), which is a labelled Glycochenodeoxycholic Acid (G641255). A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for
References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972); Iser, J.H., et al.: Drugs, 21, 90 (1981); Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986); Ollila, F., et al.: Langmuir, 17, 7107 (2001); Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004); Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005)

Formula: C₂₄H₃₃D₇O₄

Color and Shape: Neat

Molecular weight: 399.62

Ref: TR-C291904

Chenodeoxycholic acid

Controlled Product

CAS: 474-25-9

Chenodeoxycholic acid is a human primary bile acid which is also found the bile of geese. Its C-7 epimer, Ursodeoxycholic acid is found in bear’s bile. Both bile acids are used for the treatment of gallstones, although Ursodeoxycholic acid has shown superior efficacy (bear’s bile extracts are also used in Chinese medicine).

Formula: C₂₄H₄₀O₄

Purity: Min. 98 Area-%

Molecular weight: 392.58 g/mol

Ref: 3D-C-2900