CAS 475-81-0

(+)-Glaucine

Description:

(+)-Glaucine is a naturally occurring alkaloid derived from the plant Glaucium flavum, commonly known as the horned poppy. It is characterized by its structural complexity, featuring a tetracyclic framework that includes a benzene ring fused to a piperidine-like structure. This compound exhibits a range of biological activities, including antitussive (cough suppressant) and potential anti-inflammatory effects. (+)-Glaucine is known for its ability to interact with various neurotransmitter systems, particularly those involving dopamine and serotonin, which may contribute to its pharmacological properties. The substance is typically found in a crystalline form and is soluble in organic solvents, while being less soluble in water. Its stereochemistry is significant, as the (+) designation indicates the specific optical activity of the molecule, which can influence its biological interactions. Due to its effects on the central nervous system, research into (+)-Glaucine continues, focusing on its therapeutic potential and mechanisms of action.

Formula: C₂₁H₂₅NO₄

InChI: InChI=1S/C21H25NO4/c1-22-7-6-12-9-18(25-4)21(26-5)20-14-11-17(24-3)16(23-2)10-13(14)8-15(22)19(12)20/h9-11,15H,6-8H2,1-5H3/t15-/m0/s1

InChI key: InChIKey=RUZIUYOSRDWYQF-HNNXBMFYSA-N

SMILES: O(C)C1=C2C=3[C@](CC=4C2=CC(OC)=C(OC)C4)(N(C)CCC3C=C1OC)[H]

Synonyms:

• (6aS)-1,2,9,10-Tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
• (6aS)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline
• (S)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline
• (S)-Glaucine
• 4H-Dibenzo[de,g]quinoline, 5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-, (S)-
• 4H-dibenzo[de,g]quinoline, 5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-, (6aS)-
• 6a.alpha.-Aporphine, 1,2,9,10-tetramethoxy-
• 6aα-Aporphine, 1,2,9,10-tetramethoxy-
• Boldine Dimethyl Ether
• Bromcholitin
• Glauvent
• N,O,O′-Trimethyllaurelliptine
• NSC 34396
• O,O-Dimethylboldine
• O,O-Dimethylisoboldine
• d-Glaucine

BOLDINE DIMETHYL ETHER

CAS: 475-81-0

Formula: C₂₁H₂₅NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 355.4275

Ref: IN-DA00DA4W

Glaucine

CAS: 475-81-0

Glaucine

Purity: ≥98%

Molecular weight: 355.43g/mol

Ref: 54-BUP02188

Glaucine

CAS: 475-81-0

Formula: C₂₁H₂₅NO₄

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 355.434

Ref: BP-SBP02964

Glaucine

CAS: 475-81-0

Glaucine: antitussive, antioxidative, antiviral, may fight arthritis, boosts IL-10, hinders breast cancer cell spread by inhibiting MMP-9 and NF-κB.

Formula: C₂₁H₂₅NO₄

Purity: 99.42% - 99.56%

Color and Shape: Solid

Molecular weight: 355.43

Ref: TM-T5S2059

(+)-Glaucine

CAS: 475-81-0

It has bronchodilator and anti-inflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker.

Formula: C₂₁H₂₅NO₄

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 355.43 g/mol

Ref: 3D-FG65865

d-Glaucine-d6

Controlled Product

CAS: 475-81-0

Applications d-Glaucine-d6 is labelled d-Glaucine (G406900) which has bronchodilator and antiinflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker, and is used medically as an antitussive in some countries.
References Cortijo, J., et al.: Brit. J. Pharm., 127, 1641 (1999); Rühle, K., et al.: Brit. J. Clin. Pharm., 17, 521 (1984)

Formula: C₂₁H₁₉D₆NO₄

Color and Shape: Neat

Molecular weight: 361.46

Ref: TR-G406902