CAS 475108-18-0

Tivozanib

Description:

Tivozanib, with the CAS number 475108-18-0, is a small molecule tyrosine kinase inhibitor primarily used in the treatment of renal cell carcinoma. It selectively inhibits vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3), which play a crucial role in angiogenesis, the process by which new blood vessels form from pre-existing ones. This inhibition disrupts tumor blood supply, thereby limiting tumor growth and metastasis. Tivozanib is characterized by its high potency and selectivity, which contribute to its therapeutic efficacy while potentially minimizing off-target effects. The compound is typically administered orally and has a favorable pharmacokinetic profile, including a long half-life, allowing for once-daily dosing. Common side effects may include hypertension, fatigue, and gastrointestinal disturbances. As an investigational drug, Tivozanib has been evaluated in various clinical trials, demonstrating promise in improving outcomes for patients with advanced renal cell carcinoma. Its development reflects ongoing efforts to enhance targeted cancer therapies and improve patient quality of life.

Formula: C₂₂H₁₉ClN₄O₅

InChI: InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)

InChI key: InChIKey=SPMVMDHWKHCIDT-UHFFFAOYSA-N

SMILES: O(C=1C2=C(C=C(OC)C(OC)=C2)N=CC1)C3=CC(Cl)=C(NC(NC=4C=C(C)ON4)=O)C=C3

Synonyms:

• 1-[2-Chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea
• Av-951
• Fotivda
• Kil 8951
• Krn 951
• N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N′-(5-methyl-3-isoxazolyl)urea
• Tivozanib
• Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N′-(5-methyl-3-isoxazolyl)-
• N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N′-(5-methyl-3-isoxazolyl)urea
• AV951(Tivozanib)
• N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]benzaMide
• Tivozanib(AV951,KRN951)
• N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea Tivozanib (AV-951)
• AV951
• AV-951(Tivozanib)

Tivozanib

CAS: 475108-18-0

Formula: C₂₂H₁₉ClN₄O₅

Purity: %

Color and Shape: Solid

Molecular weight: 454.8631

Ref: IN-DA0070FI

Tivozanib

CAS: 475108-18-0

Tivozanib

Purity: ≥95%

Molecular weight: 454.86g/mol

Ref: 54-BUP09708

Tivozanib

CAS: 475108-18-0

Formula: C₂₂H₁₉ClN₄O₅

Purity: ≥ 98.0%

Color and Shape: White to beige or brown powder or solid

Molecular weight: 454.86

Ref: 7W-GP9162

Tivozanib

CAS: 475108-18-0

Formula: C₂₂H₁₉ClN₄O₅

Molecular weight: 454.87

Ref: 4Z-T-456001

Tivozanib

CAS: 475108-18-0

Tivozanib (KRN951) is an oral VEGFRs 1-3 inhibitor with potential antiangiogenic and cancer-fighting properties.

Formula: C₂₂H₁₉ClN₄O₅

Purity: 98.08% - 99.67%

Color and Shape: Solid

Molecular weight: 454.86

Ref: TM-T2456

Tivozanib

Controlled Product

CAS: 475108-18-0

Applications Tivozanib is known as an oral VEGF receptor tyrosine kinase inhibitor, exhibiting antitumor effects towards renal cell carcinoma.. Tivozanib suppresses angiogenesis by selectively inhibiting against vascular endothelial growth factor. Potent VEGFR inhibitor.
References Nosov, D.A., et al.: J. Clinical. Oncol., 30, 1678 (2012); Pal, S.K., et al., Molec. Cancer. Thr, 11, 526 (2012);

Formula: C₂₂H₁₉ClN₄O₅

Color and Shape: Neat

Molecular weight: 454.86

Ref: TR-T447205

Tivozanib - Bio-X ™

CAS: 475108-18-0

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₂H₁₉ClN₄O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 454.86 g/mol

Ref: 3D-BT300016

Tivozanib

CAS: 475108-18-0

Inhibitor of VEGF receptors

Formula: C₂₂H₁₉ClN₄O₅

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 454.86 g/mol

Ref: 3D-BT160380