CAS 475489-16-8

AEW-541

Description:

AEW-541, with the CAS number 475489-16-8, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is characterized by its specific molecular structure, which includes various functional groups that contribute to its biological activity. AEW-541 has been studied for its role as a selective inhibitor of certain protein kinases, which are crucial in regulating various cellular processes, including growth and metabolism. This inhibition can lead to significant effects on cancer cell proliferation and survival, making AEW-541 a candidate for cancer treatment research. Additionally, the compound's solubility, stability, and pharmacokinetic properties are essential for its efficacy and safety in potential therapeutic applications. As with many experimental compounds, ongoing research is necessary to fully understand its mechanisms of action, optimal dosing, and potential side effects. Overall, AEW-541 represents a promising area of study in the development of targeted cancer therapies.

Formula: C₂₇H₂₉N₅O

InChI: InChI=1/C27H29N5O/c28-26-25-24(21-8-4-9-23(14-21)33-17-19-6-2-1-3-7-19)16-32(27(25)30-18-29-26)22-12-20(13-22)15-31-10-5-11-31/h1-4,6-9,14,16,18,20,22H,5,10-13,15,17H2,(H2,28,29,30)/t20-,22+

InChI key: InChIKey=AECDBHGVIIRMOI-GRGXKFILNA-N

SMILES: NC1=C2C(N(C=C2C3=CC(OCC4=CC=CC=C4)=CC=C3)[C@@H]5C[C@H](CN6CCC6)C5)=NC=N1

Synonyms:

• 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-
• AVP-AEW541
• [7-[cis-3-[(Azetidin-1-yl)methyl]cyclobutyl]-5-(3-benzyloxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amine
• NVP AEW541
• [7-[cis-3-[(Azetidin-1-yl)methyl]cyclobutyl]-5-(3-benzyloxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amine
• 7-[cis-3-(1-Azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• 7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• AVP-AEW541 NVP-AEW541
• AEW-541
• [7-[cis-3-[(Azetidin-1-yl)methyl]cyclobutyl]-5-(3-benzyloxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amine AVP-AEW541
• NVP-AEW541(AEW541)

AVP-AEW541

CAS: 475489-16-8

Formula: C₂₇H₂₉N₅O

Purity: 99%

Color and Shape: Solid

Molecular weight: 439.5521

Ref: IN-DA00DB74

[7-[Cis-3-[(Azacyclobutane-1-Yl)Methyl]Cyclobutyl]-5-(3-Benzyloxyphenyl)-7H-Pyrrolo[2,3-D] Pyrimidin-4-Yl]Amine

CAS: 475489-16-8

[7-[Cis-3-[(Azacyclobutane-1-Yl)Methyl]Cyclobutyl]-5-(3-Benzyloxyphenyl)-7H-Pyrrolo[2,3-D] Pyrimidin-4-Yl]Amine

Purity: 98%

Molecular weight: 439.55g/mol

Ref: 54-OR1023746

NVP-AEW541

CAS: 475489-16-8

NVP-AEW541

Purity: ≥95%

Molecular weight: 439.55g/mol

Ref: 54-BUP01987

NVP-AEW541

CAS: 475489-16-8

NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based

Formula: C₂₇H₂₉N₅O

Purity: 98.7% - 99.86%

Color and Shape: Solid

Molecular weight: 439.55

Ref: TM-T6080

NVP-AEW541

Controlled Product

CAS: 475489-16-8

Formula: C₂₇H₂₉N₅O

Color and Shape: Neat

Molecular weight: 439.55

Ref: TR-N925640

NVP-AEW541

CAS: 475489-16-8

NVP-AEW541 is a chemical inhibitor that has been shown to inhibit cellular transformation in vitro. It inhibits the receptor activity of IGF-I, which is a protein that stimulates cell growth and proliferation. NVP-AEW541 has also been shown to inhibit cancer cells in vitro by inhibiting the polymerase chain reaction and mitochondrial membrane potential. NVP-AEW541 has not been tested for efficacy in animal models or human subjects, however it has shown promising results in colorectal adenocarcinoma cell lines and subcutaneous tumors.

Formula: C₂₇H₂₉N₅O

Purity: Min. 95%

Molecular weight: 439.55 g/mol

Ref: 3D-AUA48916