CAS 4759-48-2

isotretinoin

Description:

Isotretinoin, with the CAS number 4759-48-2, is a synthetic retinoid, primarily used in the treatment of severe acne, particularly nodular acne that has not responded to other therapies. It is a derivative of vitamin A and functions by reducing sebum production, promoting cell turnover, and exhibiting anti-inflammatory properties. Isotretinoin is characterized by its lipophilic nature, which allows it to be absorbed well in the gastrointestinal tract when taken orally. The compound has a complex molecular structure, featuring a cyclohexene ring and multiple double bonds, contributing to its biological activity. It is known for its potential side effects, including teratogenicity, which necessitates strict guidelines for its use in women of childbearing age. Additionally, isotretinoin can cause dryness of the skin and mucous membranes, as well as alterations in liver function and lipid levels. Due to its potency and side effect profile, isotretinoin is typically prescribed under careful medical supervision, often as part of a comprehensive acne treatment plan.

Formula: C₂₀H₂₈O₂

InChI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-

InChI key: InChIKey=SHGAZHPCJJPHSC-XFYACQKRSA-N

SMILES: C(=C/C(=C/C=C/C(=C\C(O)=O)/C)/C)\C=1C(C)(C)CCCC1C

Synonyms:

• (13Cis)-15-Oxidoretinal
• (13Z)-Retinoic acid
• 13-Cis-Retinoic Acid
• 13-Cis-Vitamin A Acid
• 13-Ra
• 13-cis-β-Retinoic acid
• 3,7-Dimethyl-9-(2,6,6-Trimethyl-1-Cyclohexen-1-Yl)-2-Cis-4-Trans-6-Trans-8-Trans-Nonatetraenoic Acid
• Absorica
• Accure
• Accutane
• Agn 190013
• Amnesteem
• Claravis
• Isotretinoine
• Isotretinoino
• Isotrex
• IsotrexGel
• Neovitamin A acid
• Retinoic acid, 13-cis-
• Ro 4-3780
• Roaccutan
• Roaccutane
• Roacutan
• cis-Retinoic acid

13-cis-Retinoic Acid

CAS: 4759-48-2

Formula: C₂₀H₂₈O₂

Purity: >97.0%(T)(HPLC)

Color and Shape: Orange to Brown powder to crystal

Molecular weight: 300.44

Ref: 3B-R0088

13-cis-Retinoic acid

CAS: 4759-48-2

A vitamin A analog that inhibits cell proliferation and induces cell differentiation

Formula: C₂₀H₂₈O₂

Color and Shape: Solid, Yellow to orange

Molecular weight: 300.44

Ref: 02-J61666

Tretinoin EP Impurity A

CAS: 4759-48-2

Formula: C₂₀H₂₈O₂

Molecular weight: 300.44

Ref: ST-EA-CP-T101021

ISOTRETINOIN CRS

CAS: 4759-48-2

ISOTRETINOIN CRS

Ref: 41-I0800000

Isotretinoin

CAS: 4759-48-2

Vitamins a and their derivatives unmixed

Formula: C₂₀H₂₈O₂

Color and Shape: Yellow Orange Crystalline Powder

Molecular weight: 300.20893

Ref: 45-1353500

ACCUTANE

CAS: 4759-48-2

Formula: C₂₀H₂₈O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 300.4351

Ref: IN-DA003DVB

Isotretinoin

CAS: 4759-48-2

Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote

Formula: C₂₀H₂₈O₂

Purity: 97.01% - 98.06%

Color and Shape: Reddish-Orange Plates From Isopropyl Alcohol (Ntp 1992)

Molecular weight: 300.44

Ref: TM-T1611

Isotretinoin (Tretinoin EP Impurity A, 13-cis-Retinoic Acid)

CAS: 4759-48-2

Formula: C₂₀H₂₈O₂

Color and Shape: Yellow Solid

Molecular weight: 300.44

Ref: 4Z-T-114021

Isotretinoin, USP grade

CAS: 4759-48-2

Formula: C₂₀H₂₈O₂

Purity: 98.0 - 102.0 % (dried basis)

Color and Shape: Off-white to yellow crystalline powder

Molecular weight: 300.44

Ref: 7W-GP2028

13-cis-Retinoic acid

CAS: 4759-48-2

13-cis-Retinoic acid

Purity: 98%

Molecular weight: 300.44g/mol

Ref: 54-OR1009337

Isotretinoin

CAS: 4759-48-2

Isotretinoin

Purity: ≥95%

Molecular weight: 300.44g/mol

Ref: 54-BUP15964

Isotretinoin

CAS: 4759-48-2

Formula: C₂₀H₂₈O₂

Purity: 97.5 - 102.5 % (dried basis)

Color and Shape: Off-white, pale yellow, yellow-orange or orange crystalline powder

Molecular weight: 300.44

Ref: 7W-GP6510

Isotretinoin-d5 (Tretinoin EP Impurity A-d5, 13-cis-Retinoic Acid-d5)

CAS: 4759-48-2

Formula: C₂₀H₂₃D₅O₂

Color and Shape: Orange Solid

Molecular weight: 305.47

Ref: 4Z-T-114019

13-cis-Retinoic Acid

Controlled Product

CAS: 4759-48-2

Stability Moisture, Temperature, Light Sensitive, Store in freezer
Applications Used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.
References Lerche, C., et al.: Exp. Dermatol., 17, 972 (2008), Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Gan, J., et al.: Chem. Res. Toxicol., 22, 690 (2009), Macejova, D., et al.: Toxicol. Lett., 184, 114 (2009), Chen, P., et al.: Toxicol. App. Pharmacol., 234, 143 (2009),

Formula: C₂₀H₂₈O₂

Color and Shape: Neat

Molecular weight: 300.44

Ref: TR-R250000

13-cis-Retinoic acid

Controlled Product

CAS: 4759-48-2

An endogenous retinoic acid receptor (RAR) agonist that upregulates forkhead box class O (FoxO) transcription factor. Suppresses activity and proliferation of sebaceous glands. Used for treating nodulocystic acne. Induces differentiation, neurite outgrowth and inhibits proliferation of neuroblastoma cells. A potential chemopreventive agent in non-small cell lung cancer, head and neck squamous cell carcinoma and neuroblastoma.

Formula: C₂₀H₂₈O₂

Purity: Min. 97 Area-%

Color and Shape: Yellow Powder

Molecular weight: 300.44 g/mol

Ref: 3D-FR27714

13-cis-Retinoic Acid

CAS: 4759-48-2

Formula: C₂₀H₂₈O₂

Purity: 98%

Color and Shape: No data available.

Molecular weight: 300.442

Ref: 10-M02448

13-cis-Retinoic Acid-13C3

Controlled Product

CAS: 4759-48-2

Applications 13-cis-Retinoic Acid-13C3, is the labeled analogue of 13-cis-Retinoic Acid (R250002), used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.
References Lerche, C., et al.: Exp. Dermatol., 17, 972 (2008), Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Gan, J., et al.: Chem. Res. Toxicol., 22, 690 (2009), Macejova, D., et al.: Toxicol. Lett., 184, 114 (2009), Chen, P., et al.: Toxicol. App. Pharmacol., 234, 143 (2009),

Formula: C₃C₁₇H₂₈O₂

Color and Shape: Neat

Molecular weight: 303.413

Ref: TR-R250003

13-cis-Retinoic Acid-d5

Controlled Product

CAS: 4759-48-2

Applications 13-cis-Retinoic Acid-d5, is the labeled analogue of 13-cis-Retinoic Acid (R250000) used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.
References Lerche, C., et al.: Exp. Dermatol., 17, 972 (2008), Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Gan, J., et al.: Chem. Res. Toxicol., 22, 690 (2009), Macejova, D., et al.: Toxicol. Lett., 184, 114 (2009), Chen, P., et al.: Toxicol. App. Pharmacol., 234, 143 (2009),

Formula: C₂₀H₂₃D₅O₂

Color and Shape: Neat

Molecular weight: 305.466

Ref: TR-R250004

Isotretinoin

Controlled Product

CAS: 4759-48-2

An endogenous retinoic acid receptor (RAR) agonist that upregulates forkhead box class O (FoxO) transcription factor. Suppresses activity and proliferation of sebaceous glands. Used for treating nodulocystic acne. Induces differentiation, neurite outgrowth and inhibits proliferation of neuroblastoma cells. A potential chemopreventive agent in non-small cell lung cancer, head and neck squamous cell carcinoma and neuroblastoma.

Formula: C₂₀H₂₈O₂

Purity: Min. 95%

Molecular weight: 300.44 g/mol

Ref: 3D-BR164589