CAS 4759-48-2: isotretinoin

Description: Isotretinoin, with the CAS number 4759-48-2, is a synthetic retinoid, primarily used in the treatment of severe acne, particularly nodular acne that has not responded to other therapies. It is a derivative of vitamin A and functions by reducing sebum production, promoting cell turnover, and exhibiting anti-inflammatory properties. Isotretinoin is characterized by its lipophilic nature, which allows it to be absorbed well in the gastrointestinal tract when taken orally. The compound has a complex molecular structure, featuring a cyclohexene ring and multiple double bonds, contributing to its biological activity. It is known for its potential side effects, including teratogenicity, which necessitates strict guidelines for its use in women of childbearing age. Additionally, isotretinoin can cause dryness of the skin and mucous membranes, as well as alterations in liver function and lipid levels. Due to its potency and side effect profile, isotretinoin is typically prescribed under careful medical supervision, often as part of a comprehensive acne treatment plan.

Formula: C₂₀H₂₇O₂

InChI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-

InChI key: InChIKey=SHGAZHPCJJPHSC-XFYACQKRSA-N

SMILES: O=C(O)C=C(C=CC=C(C=CC1=C(C)CCCC1(C)C)C)C

Synonyms:

• (13Cis)-15-Oxidoretinal
• (13Z)-Retinoic acid
• 13-Cis-Retinoic Acid
• 13-Cis-Vitamin A Acid
• 13-Ra
• 13-cis-β-Retinoic acid
• 3,7-Dimethyl-9-(2,6,6-Trimethyl-1-Cyclohexen-1-Yl)-2-Cis-4-Trans-6-Trans-8-Trans-Nonatetraenoic Acid
• Absorica
• Accure
• Accutane
• Agn 190013
• Amnesteem
• Claravis
• Isotretinoine
• Isotretinoino
• Isotrex
• IsotrexGel
• Neovitamin A acid
• Retinoic acid, 13-cis-
• Ro 4-3780
• Roaccutan
• Roaccutane
• Roacutan
• cis-Retinoic acid

13-cis-Retinoic Acid

CAS: 4759-48-2

• Formula: C₂₀H₂₈O₂
• Purity: >97.0%(T)(HPLC)
• Color and Shape: Orange to Brown powder to crystal
• Molecular weight: 300.44

13-cis-Retinoic acid

CAS: 4759-48-2

13-cis-Retinoic acid is used to inhibits cell proliferation and induces cell differentiation. 13-cis-Retinoic acid is …

• Formula: C₂₀H₂₈O₂
• Color and Shape: Solid, Yellow to orange
• Molecular weight: 300.44

Isotretinoin CRS

CAS: 4759-48-2

Isotretinoin

CAS: 4759-48-2

Vitamins a and their derivatives unmixed

• Formula: C₂₀H₂₈O₂
• Color and Shape: Yellow Orange Crystalline Powder
• Molecular weight: 300.20893

Isotretinoin

CAS: 4759-48-2

Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve …

• Formula: C₂₀H₂₈O₂
• Purity: 98.06% - 99.61%
• Color and Shape: Reddish-Orange Plates From Isopropyl Alcohol (Ntp 1992)
• Molecular weight: 300.44

ACCUTANE

CAS: 4759-48-2

• Formula: C₂₀H₂₈O₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 300.4351

Isotretinoin (Tretinoin EP Impurity A, 13-cis-Retinoic Acid)

CAS: 4759-48-2

• Formula: C₂₀H₂₈O₂
• Color and Shape: Yellow Solid
• Molecular weight: 300.44

Isotretinoin, USP grade

CAS: 4759-48-2

• Formula: C₂₀H₂₈O₂
• Purity: 98.0 - 102.0 % (dried basis)
• Color and Shape: Off-white to yellow crystalline powder
• Molecular weight: 300.44

13-cis-Retinoic acid

CAS: 4759-48-2

• Purity: 98%
• Molecular weight: 300.44g/mol

Isotretinoin

CAS: 4759-48-2

• Purity: 99.6%
• Molecular weight: 300.44g/mol

Isotretinoin

CAS: 4759-48-2

• Formula: C₂₀H₂₈O₂
• Purity: 97.5 - 102.5 % (dried basis)
• Color and Shape: Off-white, pale yellow, yellow-orange or orange crystalline powder
• Molecular weight: 300.44

Isotretinoin-d5 (Tretinoin EP Impurity A-d5, 13-cis-Retinoic Acid-d5)

CAS: 4759-48-2

• Formula: C₂₀H₂₃D₅O₂
• Color and Shape: Orange Solid
• Molecular weight: 305.47

13-cis-Retinoic acid, 99%

CAS: 4759-48-2

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₂₀H₂₈O₂
• Purity: 99%
• Color and Shape: Yellow to orange, Crystalline powder
• Molecular weight: 300.44

13-cis-Retinoic Acid

CAS: 4759-48-2

• Purity: >95%
• Color and Shape: Solid, No data available.
• Molecular weight: 300.4419860839844

13-cis-Retinoic Acid

CAS: 4759-48-2

Stability Moisture, Temperature, Light Sensitive, Store in freezer Applications Used as a treatment for severe …

• Formula: C₂₀H₂₈O₂
• Color and Shape: Neat
• Molecular weight: 300.44

13-cis-Retinoic acid

CAS: 4759-48-2

An endogenous retinoic acid receptor (RAR) agonist that upregulates forkhead box class O (FoxO) transcription …

• Formula: C₂₀H₂₈O₂
• Purity: Min. 97 Area-%
• Color and Shape: Yellow Powder
• Molecular weight: 300.44 g/mol

13-cis-Retinoic Acid-13C3

CAS: 4759-48-2

Applications 13-cis-Retinoic Acid-13C3, is the labeled analogue of 13-cis-Retinoic Acid (R250002), used as a treatment …

• Formula: C₃C₁₇H₂₈O₂
• Color and Shape: Neat
• Molecular weight: 303.413

13-cis-Retinoic Acid-d5

CAS: 4759-48-2

Applications 13-cis-Retinoic Acid-d5, is the labeled analogue of 13-cis-Retinoic Acid (R250000) used as a treatment …

• Formula: C₂₀H₂₃D₅O₂
• Color and Shape: Neat
• Molecular weight: 305.466

Isotretinoin

CAS: 4759-48-2

An endogenous retinoic acid receptor (RAR) agonist that upregulates forkhead box class O (FoxO) transcription …

• Formula: C₂₀H₂₈O₂
• Purity: Min. 95%
• Molecular weight: 300.44 g/mol