CAS 4769-97-5

4-Nitroindole

Description:

4-Nitroindole is an organic compound characterized by the presence of both an indole and a nitro functional group. It features a bicyclic structure consisting of a fused benzene and pyrrole ring, with a nitro group (-NO2) positioned at the 4-position of the indole ring. This compound typically appears as a yellow to orange solid and is known for its potential applications in organic synthesis and as a building block in pharmaceuticals. 4-Nitroindole exhibits moderate solubility in organic solvents, such as ethanol and dimethyl sulfoxide, but is less soluble in water. The presence of the nitro group contributes to its electronic properties, making it a useful intermediate in various chemical reactions, including nitration and reduction processes. Additionally, 4-Nitroindole can participate in various biological activities, which has garnered interest in medicinal chemistry. However, handling this compound requires caution due to its potential toxicity and environmental impact.

Formula: C₈H₆N₂O₂

InChI: InChI=1S/C8H6N2O2/c11-10(12)8-3-1-2-7-6(8)4-5-9-7/h1-5,9H

InChI key: InChIKey=LAVZKLJDKGRZJG-UHFFFAOYSA-N

SMILES: N(=O)(=O)C1=C2C(NC=C2)=CC=C1

Synonyms:

• 1H-Indole, 4-nitro-
• 4-Nitro indole
• 4-Nitro-1H-indole
• Indole, 4-nitro-
• 4-Nitroindole

4-Nitroindole

CAS: 4769-97-5

Formula: C₈H₆N₂O₂

Purity: >98.0%(GC)

Color and Shape: Orange to Brown powder to crystal

Molecular weight: 162.15

Ref: 3B-N0628

4-Nitroindole

CAS: 4769-97-5

Formula: C₈H₆N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 162.1454

Ref: IN-DA00344J

4-Nitroindole

CAS: 4769-97-5

Formula: C₈H₆N₂O₂

Molecular weight: 162.15

Ref: 7W-GP0972

4-Nitro-1H-indole

CAS: 4769-97-5

4-Nitro-1H-indole

Formula: C₈H₆N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 162.14544

Ref: 54-OR7858

4-Nitroindole

CAS: 4769-97-5

4-Nitroindole is a chemical compound that is used to synthesize 5-hydroxytryptamine (5-HT) and also has been used as a substitute for tryptophan in the synthesis of serotonin. It can be prepared by reacting sodium nitrite with an organic acid such as acetic acid or propionic acid. The reaction proceeds through a diazonium salt intermediate, which is hydrolyzed with hydrochloric acid to give 4-nitroindole. 4-Nitroindole can also be prepared by the Friedel-Crafts reaction between an aromatic nitro compound and an alkyl halide. The hydrogen bond between the hydroxyl group and nitrogen atom in the molecule makes it soluble in organic solvents. In addition, the constant boiling point of the compound allows it to be analyzed using gas chromatography.

Formula: C₈H₆N₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 162.15 g/mol

Ref: 3D-FN11792

4-Nitroindole

CAS: 4769-97-5

Formula: C₈H₆N₂O₂

Purity: 97%

Color and Shape: Solid, Yellow to orange powder

Molecular weight: 162.148

Ref: 10-F077925