CAS 477-30-5

Demecolcine

Description:

Demecolcine is a chemical compound classified as a colchicine derivative, primarily known for its use in biological research and as a potential therapeutic agent. It is characterized by its ability to inhibit microtubule polymerization, which disrupts mitotic spindle formation, making it valuable in studies of cell division and cancer research. Demecolcine is typically presented as a white to off-white crystalline powder, and it is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and slightly soluble in water. The compound has a molecular formula that reflects its complex structure, which includes a phenolic ring and a methoxy group. Due to its biological activity, demecolcine has been investigated for its potential applications in treating certain types of cancer and genetic disorders, although its use is often limited by toxicity and side effects. As with many chemical substances, proper handling and safety precautions are essential when working with demecolcine in laboratory settings.

Formula: C₂₁H₂₅NO₅

InChI: InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1

InChI key: InChIKey=NNJPGOLRFBJNIW-HNNXBMFYSA-N

SMILES: O(C)C1=C2C=3C([C@@H](NC)CCC2=CC(OC)=C1OC)=CC(=O)C(OC)=CC3

Synonyms:

• (-)-Colchamine
• (7S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
• (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
• (7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one
• (N-Desacetyl-N-methylcolchicine)
• 1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
• Alkaloid H 3, from Colchicum antumnale
• Alkaloid H 3, from Colchicumantumnale
• Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (7S)-
• Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-
• C 12669
• Ciba 12669A
• Colcemid
• Colcemide
• Colchamin
• Colchicine, N-deacetyl-N-methyl-
• Deacetyl-N-methylcolchicine
• Deacetylmethylcolchicine
• Demecolcin
• Demecolcina
• Demecolcine
• Demecolcine, (S)-(-)-
• Desacetylmethylcolchicine
• Desmecolcine
• Kolchamin
• N-Deacetyl-N-methylcolchicine
• N-Methyl-N-deacetylcolchicine
• N-Methyl-N-desacetylcolchicine
• N-Methyltri-O-methylcolchicinic acid
• Nsc 3096
• Omain
• Omaine
• Reichstein's F
• Santavy's substance F

Demecolcine

CAS: 477-30-5

Formula: C₂₁H₂₅NO₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 371.4269

Ref: IN-DA00DDYO

Colcemid

CAS: 477-30-5

Colcemid

Purity: ≥98%

Molecular weight: 371.43g/mol

Ref: 54-BUP02609

(-)-Demecolcine

CAS: 477-30-5

(-)-Demecolcine

Purity: 97%

Molecular weight: 371.43g/mol

Ref: 54-OR1023885

Demecolcine

CAS: 477-30-5

Formula: C₂₁H₂₅NO₅

Purity: ≥ 98.0%

Color and Shape: White, off-white or pale yellow crystalline powder

Molecular weight: 371.43

Ref: 7W-GP5459

Demecolcine-13C,d3

CAS: 477-30-5

Formula: C₂₀₁₃CH₂₂D₃NO₅

Molecular weight: 375.44

Ref: 4Z-C-1530

Demecolcine

CAS: 477-30-5

Formula: C₂₁H₂₅NO₅

Molecular weight: 371.43

Ref: 4Z-C-1533

Demecolcine

CAS: 477-30-5

Stability Hygroscopic
Applications An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),

Formula: C₂₁H₂₅NO₅

Color and Shape: Neat

Molecular weight: 371.43

Ref: TR-D230785

Colcemid

CAS: 477-30-5

Colcemid (NSC-3096) is a microtubule polymerization inhibitor,main target being Tubulin and an IC50 of 2.4 μM. induce apoptosis. High-Quality, Low-Cost!

Formula: C₂₁H₂₅NO₅

Purity: 99.65% - 99.83%

Color and Shape: Solid

Molecular weight: 371.43

Ref: TM-T19720

Demecolcine

CAS: 477-30-5

Demecolcine is a substance that is found in plants. It has been shown to have cytotoxic effects on human cells and to inhibit the growth of hl-60 cells by interfering with microtubule formation. Demecolcine binds to the microtubules, preventing them from polymerizing and causing mitotic arrest in cell cycle. Demecolcine also blocks the production of tubulin, which are proteins that are needed for microtubule formation. This drug has been shown to be effective against colchicine-resistant cells that are resistant to other cytotoxic agents as well. The rate constant for demecolcine's binding to microtubules is 0.2 s-1, which is higher than that of colchicine (0.05 s-1). The signal peptide sequence of demecolcine has been found in human chromosome 1q42 and chromosome 4q21, suggesting it may play a role in the

Formula: C₂₁H₂₅NO₅

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 371.43 g/mol

Ref: 3D-FC15451

Demecolcine

CAS: 477-30-5

Please enquire for more information about Demecolcine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₂₁H₂₅NO₅

Purity: Min. 98 Area-%

Molecular weight: 371.43 g/mol

Ref: 3D-J-100064