CAS 477-57-6

1-Isotetrandrine

Description:

1-Isotetrandrine, with the CAS number 477-57-6, is a chemical compound that belongs to the class of benzophenanthridine alkaloids. It is primarily derived from the plant species of the Menispermaceae family, particularly from the plant Stephania tetrandra. This compound is characterized by its complex polycyclic structure, which contributes to its biological activity. 1-Isotetrandrine exhibits various pharmacological properties, including anti-inflammatory, analgesic, and potential anti-cancer effects. It has been studied for its ability to modulate calcium channels and influence vascular smooth muscle contraction, making it of interest in cardiovascular research. Additionally, 1-Isotetrandrine has shown promise in traditional medicine, particularly in Asian herbal practices. Its solubility is generally low in water but can be dissolved in organic solvents, which is typical for many alkaloids. As with many bioactive compounds, further research is ongoing to fully elucidate its mechanisms of action and potential therapeutic applications.

Formula: C₃₈H₄₂N₂O₆

InChI: InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30+/m0/s1

InChI key: InChIKey=WVTKBKWTSCPRNU-XZWHSSHBSA-N

SMILES: O(C)C1=C2C=3[C@@](CC=4C=C(C(OC)=CC4)OC=5C=CC(C[C@]6(C7=CC(O2)=C(OC)C=C7CCN6C)[H])=CC5)(N(C)CCC3C=C1OC)[H]

Synonyms:

• (1Beta,1'Beta)-6,6',7,12-Tetramethoxy-2,2'-Dimethylberbaman
• (4aS,16aR)-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline
• (R,S)-Tetrandrine
• 1-Isotetrandrine
• 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aR)-
• 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, [4aS-(4aR*,16aS*)]-
• 6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman
• 8,19,20,25-Tetramethoxy-14,30-Dimethyl-6,22-Dioxa-14,30-Diazaheptacyclo[22.6.2.2~2,5~.1~7,11~.1~13,17~.0~21,33~.0~27,31~]Hexatriaconta-2,4,7(34),8,10,17(33),18,20,24,26,31,35-Dodecaene (Non-Preferred Name)
• Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl- (9CI)
• Berbaman, 6,6′,7,12-tetramethoxy-2,2′-dimethyl-
• Ccris 6540
• Isosinomenin A
• Isosinomenine A
• Nsc 97338
• O,O'-Dimethylobamegine
• O,O'-Dimethylstepholine
• O-Methylberbamine

Isotetrandrine

CAS: 477-57-6

Formula: C₃₈H₄₂N₂O₆

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 622.7499

Ref: IN-DA00D7Z3

Isotetrandrine

CAS: 477-57-6

Formula: C₃₈H₄₂N₂O₆

Purity: 95%~99%

Molecular weight: 622.762

Ref: BP-BP0802

Isotetrandrine

CAS: 477-57-6

Formula: C₃₈H₄₂N₂O₆

Molecular weight: 622.76

Ref: 4Z-T-254001

Isotetrandrine

Controlled Product

CAS: 477-57-6

Applications Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2.
References Abe, T., et al.: Toxicon, 38, 1803 (2003); Matsuno, T., et al.: Biochem. Pharmacol., 36, 1613 (1987); Matsuno, T., et al.: Igaku to Yakugaku, 16, 445 (1986)

Formula: C₃₈H₄₂N₂O₆

Color and Shape: Neat

Molecular weight: 622.75

Ref: TR-I918015

Isotetrandrine

CAS: 477-57-6

Isotetrandrine is a bis-benzylisoquinoline alkaloid, which is derived from traditional herbal sources, specifically the Stephania genus of plants. Its mode of action involves the inhibition of various ion channels, including calcium channels, which plays a significant role in its pharmacological profile.

Formula: C₃₈H₄₂N₂O₆

Purity: Min. 95%

Molecular weight: 622.75 g/mol

Ref: 3D-FI71710

Isotetrandrine

CAS: 477-57-6

Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of LPS-induced ALI by inactivation of MAPK and NF-κB, which may involve the inhibition of tissue

Formula: C₃₈H₄₂N₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 622.75

Ref: TM-TN1806