CAS 478-01-3

Nobiletin

Description:

Nobiletin is a naturally occurring flavonoid, primarily found in citrus fruits, particularly in the peels of oranges and tangerines. It belongs to the class of compounds known as polymethoxyflavones, characterized by multiple methoxy groups attached to the flavone backbone. Nobiletin exhibits a range of biological activities, including antioxidant, anti-inflammatory, and potential anticancer properties, making it a subject of interest in nutritional and pharmaceutical research. Its chemical structure contributes to its ability to modulate various signaling pathways, which may have implications for health benefits, particularly in metabolic and cardiovascular diseases. Nobiletin is also noted for its low solubility in water, which can affect its bioavailability and absorption in the human body. As a dietary supplement, it is often studied for its potential protective effects against oxidative stress and its role in promoting overall health. However, further research is needed to fully understand its mechanisms of action and therapeutic potential.

Formula: C₂₁H₂₂O₈

InChI: InChI=1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3

InChI key: InChIKey=MRIAQLRQZPPODS-UHFFFAOYSA-N

SMILES: O(C)C1=C2C(=C(OC)C(OC)=C1OC)OC(=CC2=O)C3=CC(OC)=C(OC)C=C3

Synonyms:

• 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
• 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
• 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one
• 3′,4′,5,6,7,8-Hexamethoxyflavone
• 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-
• 5,6,7,8,3′,4′-Hexamethoxyflavone
• Ccris 9012
• Flavone, 3′,4′,5,6,7,8-hexamethoxy-
• Hexamethoxyflavone
• NSC 618903
• Nsc 76751
• Pmf 90

Nobiletin

CAS: 478-01-3

Formula: C₂₁H₂₂O₈

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 402.40

Ref: 3B-N0871

Nobiletin

CAS: 478-01-3

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₂₁H₂₂O₈

Color and Shape: Powder

Molecular weight: 402.13147

Ref: 45-1467848

Nobiletin

CAS: 478-01-3

Nobiletin

Formula: C₂₁H₂₂O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 402.39

Ref: 54-OR1027739

Nobiletin

CAS: 478-01-3

Nobiletin

Formula: C₂₁H₂₂O₈

Purity: ≥98%

Molecular weight: 402.39

Ref: 54-BUP15504

Nobiletin, 95%

CAS: 478-01-3

Formula: C₂₁H₂₂O₈

Purity: ≥ 95.0% (dried basis)

Color and Shape: White, off-white or light-yellow powder

Molecular weight: 402.39

Ref: 7W-GP8719

3',4',5,6,7,8-Hexamethoxyflavone

CAS: 478-01-3

Formula: C₂₁H₂₂O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 402.3946

Ref: IN-DA003T9A

Nobiletin

CAS: 478-01-3

Nobiletin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₂₁H₂₂O₈

Purity: (HPLC) ≥99%

Color and Shape: Powder

Molecular weight: 402.4

Ref: 11-1348S

Nobiletin

CAS: 478-01-3

Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities, it could be a potential protective agent for the prevention and treatment of restenosis after angioplasty. Nobiletin downregulated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2), suppressed cell viability through AKT pathways.

Formula: C₂₁H₂₂O₈

Purity: 95%~99%

Molecular weight: 402.399

Ref: BP-BP1001

Nobiletin (Standard)

CAS: 478-01-3

Nobiletin (Standard) is a reference standard for research and analysis in studies involving Nobiletin. Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa).

Formula: C₂₁H₂₂O₈

Molecular weight: 402.3946

Ref: TM-TMSM-1076

Nobiletin

Controlled Product

CAS: 478-01-3

Stability Light Sensitive
Applications Nobiletin is an O-methylated flavone, a flavonoid isolated from citrus peels like in tangerine. It is a potent antioxidant with good bioavailability. Nobiletin directly inhibits the ATP-binding cassette proteins P-glycoprotein and breast cancer resistance protein.
References Shen, C., et al.: J. Nutr. Biochem. 23, 1367 (2012); Pick, A., et al.: Bioorg. Med. Chem., 19, 2090 (2011); Wang, E., et al.: Chem. Res. Toxicol., 14, 1596 (2001)

Formula: C₂₁H₂₂O₈

Color and Shape: Neat

Molecular weight: 402.39

Ref: TR-N633500

Nobiletin, 98%

CAS: 478-01-3

Formula: C₂₁H₂₂O₈

Purity: ≥ 98.0%

Color and Shape: White, off-white or light-yellow powder

Molecular weight: 402.39

Ref: 7W-GP8339

Nobiletin

CAS: 478-01-3

2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one

Formula: C₂₁H₂₂O₈

Purity: 99%

Molecular weight: 402.39

Ref: IN-DG9146

Nobiletin

CAS: 478-01-3

Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.

Formula: C₂₁H₂₂O₈

Purity: 98.65% - 99.95%

Color and Shape: Yellow Solid

Molecular weight: 402.3946

Ref: TM-T2834

Nobiletin

CAS: 478-01-3

Oxygen-heterocyclic compound

Formula: C₂₁H₂₂O₈

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 402.4

Ref: 5G-80858

Nobiletin

CAS: 478-01-3

Formula: C₂₁H₂₂O₈

Color and Shape: Solid

Molecular weight: 402.4

Ref: BE-RMT13303

NOBILETIN

CAS: 478-01-3

Purity: 99%

Color and Shape: Solid

Molecular weight: 402.3989868

Ref: 10-F808050

3',4',5,6,7,8-Hexamethoxyflavone

CAS: 478-01-3

3',4',5,6,7,8-Hexamethoxyflavone is a polymethoxylated flavone, which is a type of specialized chemical compound known as a flavonoid. It naturally occurs in certain plants, particularly those within the citrus family, serving as a secondary metabolite. Polymethoxylated flavones like this one are of interest due to their potential interaction with various biological pathways.

Formula: C₂₁H₂₂O₈

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 402.39 g/mol

Ref: 3D-FH32619