CAS 479347-86-9: NBQX disodium
Description:NBQX disodium is a potent and selective antagonist of the AMPA and kainate subtypes of glutamate receptors, which are critical for fast excitatory neurotransmission in the central nervous system. This compound is often utilized in neuroscience research to study synaptic transmission and plasticity, as well as to investigate the role of glutamate in various neurological disorders. NBQX disodium is characterized by its ability to inhibit excitatory postsynaptic currents, making it valuable in experiments aimed at understanding excitotoxicity and neurodegenerative diseases. The disodium salt form enhances its solubility in aqueous solutions, facilitating its use in in vitro and in vivo studies. Additionally, NBQX has been shown to have neuroprotective effects in certain models of brain injury, further underscoring its significance in pharmacological research. Its chemical structure includes a quinoxaline backbone, contributing to its receptor-binding properties. Overall, NBQX disodium serves as an essential tool in the exploration of glutamatergic signaling pathways and their implications in health and disease.
Formula:C12H8N4O6S·2Na
InChI:InChI=1S/C12H8N4O6S.2Na/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);;
InChI key:InChIKey=ZYIPFJPOGWRVIX-UHFFFAOYSA-N
SMILES:[Na].O=C1NC=2C=C(C=3C(=CC=CC3S(=O)(=O)N)C2NC1=O)N(=O)=O
- Synonyms:
- NBQX disodium
- Benzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-, disodium salt
- Benzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-, sodium salt (1:2)
![Benzo[f]quinoxaline-7-sulfonamide,1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-,sodium salt(1:2)](https://static.cymitquimica.com/products/IN/thumb/DA00376B.jpg)
![6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt](https://static.cymitquimica.com/products/TR/thumb/N550005.jpg)
