CAS 479347-86-9

NBQX disodium

Description:

NBQX disodium is a potent and selective antagonist of the AMPA and kainate subtypes of glutamate receptors, which are critical for fast excitatory neurotransmission in the central nervous system. This compound is often utilized in neuroscience research to study synaptic transmission and plasticity, as well as to investigate the role of glutamate in various neurological disorders. NBQX disodium is characterized by its ability to inhibit excitatory postsynaptic currents, making it valuable in experiments aimed at understanding excitotoxicity and neurodegenerative diseases. The disodium salt form enhances its solubility in aqueous solutions, facilitating its use in in vitro and in vivo studies. Additionally, NBQX has been shown to have neuroprotective effects in certain models of brain injury, further underscoring its significance in pharmacological research. Its chemical structure includes a quinoxaline backbone, contributing to its receptor-binding properties. Overall, NBQX disodium serves as an essential tool in the exploration of glutamatergic signaling pathways and their implications in health and disease.

Formula: C₁₂H₈N₄O₆S·2Na

InChI: InChI=1S/C12H8N4O6S.2Na/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);;

InChI key: InChIKey=ZYIPFJPOGWRVIX-UHFFFAOYSA-N

SMILES: S(N)(=O)(=O)C=1C=2C(=C3C(=CC2N(=O)=O)NC(=O)C(=O)N3)C=CC1.[Na]

Synonyms:

• NBQX disodium
• Benzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-, disodium salt
• Benzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-, sodium salt (1:2)

NBQX disodium

CAS: 479347-86-9

NBQX Disodium (FG9202 disodium) is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity.

Formula: C₁₂H₆N₄Na₂O₆S

Purity: 97.32% - 97.6%

Color and Shape: Brown Solid

Molecular weight: 380.2415

Ref: TM-T25853

Benzo[f]quinoxaline-7-sulfonamide,1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-,sodium salt(1:2)

CAS: 479347-86-9

Formula: C₁₂H₆N₄Na₂O₆S

Purity: 97.6%

Color and Shape: Solid

Molecular weight: 380.2438

Ref: IN-DA00376B

NBQX Disodium

CAS: 479347-86-9

NBQX Disodium

Formula: C₁₂H₆N₄Na₂O₆S

Purity: ≥95%

Molecular weight: 380.24

Ref: 54-BUP00961

NBQX disodium

CAS: 479347-86-9

NBQX is a competitive antagonist of ionotropic glutamate receptors of AMPA and kainate subfamilies. It has been reported anti-convulsant activity in seizures models induced by electrostimulation, drugs or genetic predisposition. It has also exhibited pro-convulsant effects in Theiler's murine encephalomyelitis virus-induced (TMEV) seizure model.

Formula: C₁₂H₈N₄O₆S•Na₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 382.26 g/mol

Ref: 3D-FN26278

NBQX disodium salt - Bio-X ™

CAS: 479347-86-9

NBQX is a competitive antagonist of ionotropic glutamate receptors of AMPA and kainate subfamilies. It has been reported anti-convulsant activity in seizures models induced by electrostimulation, drugs or genetic predisposition.

Formula: C₁₂H₆N₄Na₂O₆S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 380.24 g/mol

Ref: 3D-BN164674

6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt

CAS: 479347-86-9

Stability Hygroscopic
Applications A potent and discriminating antagonist for AMPA binding sites.
References HonorÈ, T., et al.: Science, 241, 701 (1988), Gill, et al.: Brain Res., 580, 35 (1992), Pook, et al.: Br. J. Pharmacol., 108, 179 (1993)

Formula: C₁₂H₆N₄O₆S·2Na

Color and Shape: Neat

Molecular weight: 380.24

Ref: TR-N550005