CAS 480-11-5

Oroxylin A

Description:

Oroxylin A, with the CAS number 480-11-5, is a flavonoid compound primarily found in various plants, particularly in the roots of the medicinal herb Scutellaria baicalensis. It is characterized by its yellowish color and is known for its diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. Structurally, Oroxylin A features a flavone backbone, which contributes to its ability to interact with various biological targets. This compound has garnered interest in pharmacological research due to its potential therapeutic effects, including its role in modulating signaling pathways related to cell survival and apoptosis. Additionally, Oroxylin A has been studied for its effects on cognitive function and its potential use in treating neurodegenerative diseases. Its solubility in organic solvents and limited solubility in water are important characteristics that influence its bioavailability and application in medicinal formulations. Overall, Oroxylin A represents a significant compound in the field of natural products and pharmacognosy, with ongoing research aimed at elucidating its full therapeutic potential.

Formula: C₁₆H₁₂O₅

InChI: InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3

InChI key: InChIKey=LKOJGSWUMISDOF-UHFFFAOYSA-N

SMILES: OC1=C2C(OC(=CC2=O)C3=CC=CC=C3)=CC(O)=C1OC

Synonyms:

• 4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl-
• 5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one
• 5,7-dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one
• 6-Methoxybaicalein
• Baicalein 6-methyl ether
• Flavone, 5,7-dihydroxy-6-methoxy-
• Oroxylin
• oroxylin A

Oroxylin A

CAS: 480-11-5

Formula: C₁₆H₁₂O₅

Purity: >98.0%(HPLC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 284.27

Ref: 3B-O0635

Oroxylin A

CAS: 480-11-5

Oroxylin A

Formula: C₁₆H₁₂O₅

Purity: 99.5%

Color and Shape: Solid

Molecular weight: 284.26

Ref: 54-BUP00041

5,7-Dihydroxy-6-Methoxy-2-Phenyl-4H-Chromen-4-One

CAS: 480-11-5

5,7-Dihydroxy-6-Methoxy-2-Phenyl-4H-Chromen-4-One

Formula: C₁₆H₁₂O₅

Purity: 98%

Molecular weight: 284.26

Ref: 54-OR1027911

5,7-Dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one

CAS: 480-11-5

Formula: C₁₆H₁₂O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 284.2635

Ref: IN-DA003THU

Oroxylin A (Standard)

CAS: 480-11-5

Oroxylin A (Standard) is a reference standard for research and analysis in studies involving Oroxylin A. 1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 3. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. 4. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. 5. Oroxylin A improves the sensitivity of K562/ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K/Akt/NF-κB pathway, and probably served as a most promising agent for CML treatment.

Formula: C₁₆H₁₂O₅

Molecular weight: 284.2635

Ref: TM-TMSM-2618

Oroxylin A

CAS: 480-11-5

Oroxylin A has anticancer,.anti-inflammation, antithrombotic,antibacterial, anti-pruritic effects, it can inhibit LPS-induced iNOS and COX-2 gene expression by blocking NF-κB activation. Oroxylin A reverses MDR by G2/M arrest and the underlying mechanism attributed to the suppression of P-gp expression via Chk2/P53/NF-κB signaling pathway. Oroxylin A facilitates memory consolidation through brain-derived neurotrophic factor (BDNF)-TrkB signaling.

Formula: C₁₆H₁₂O₅

Purity: 95%~99%

Molecular weight: 284.267

Ref: BP-BP1045

Oroxylin A

CAS: 480-11-5

Formula: C₁₆H₁₂O₅

Purity: ≥ 95.0%

Color and Shape: Pale yellow to yellow powder

Molecular weight: 284.26

Ref: 7W-GL6913

Oroxylin A

CAS: 480-11-5

Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.

Formula: C₁₆H₁₂O₅

Purity: 98.72% - 99.98%

Color and Shape: White Solid

Molecular weight: 284.2635

Ref: TM-T6S1315

5,7-Dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one

CAS: 480-11-5

5,7-Dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one

Formula: C₁₆H₁₂O₅

Purity: 98%

Molecular weight: 284.26

Ref: IN-DG146312

Oroxylin A

CAS: 480-11-5

Oxygen-heterocyclic compound

Formula: C₁₆H₁₂O₅

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 284.27

Ref: 5G-82615

Oroxylin A

CAS: 480-11-5

Oroxylin A is a natural flavonoid compound, which is derived from the root of Scutellaria baicalensis, commonly known as Baikal skullcap. It is primarily recognized for its bioactive properties, attributed to its modulation of various biochemical pathways. Oroxylin A acts by inhibiting the activity of certain enzymes, such as cyclooxygenase, and influencing signaling pathways like NF-kB, which are integral to inflammatory responses. It also exhibits potent neuroprotective effects by interacting with GABA_A receptors, thereby influencing neurotransmission.

Formula: C₁₆H₁₂O₅

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 284.26 g/mol

Ref: 3D-FO63225

Oroxylin A

CAS: 480-11-5

Formula: C₁₆H₁₂O₅

Molecular weight: 284.26

Ref: BE-RMT12156

OROXYLIN A

CAS: 480-11-5

Purity: 97%

Molecular weight: 284.2669983

Ref: 10-F809645