CAS 480449-70-5

Edoxaban

Description:

Edoxaban is an oral anticoagulant that belongs to the class of direct factor Xa inhibitors, which are used primarily for the prevention and treatment of thromboembolic disorders, such as deep vein thrombosis and pulmonary embolism. Its mechanism of action involves the selective inhibition of factor Xa, an essential enzyme in the coagulation cascade, thereby reducing thrombin generation and preventing clot formation. Edoxaban is characterized by its high bioavailability and predictable pharmacokinetics, allowing for fixed dosing without the need for routine monitoring of coagulation parameters. The substance is typically administered in tablet form and is metabolized primarily by the liver, with renal excretion playing a significant role in its clearance. Common side effects may include bleeding complications, which are a risk associated with all anticoagulants. Edoxaban is often favored for its convenience and efficacy, making it a valuable option in the management of various cardiovascular conditions.

Formula: C₂₄H₃₀ClN₇O₄S

InChI: InChI=1S/C24H30ClN7O4S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34)/t13-,15-,17+/m0/s1

InChI key: InChIKey=HGVDHZBSSITLCT-JLJPHGGASA-N

SMILES: N(C(=O)C1=NC2=C(S1)CN(C)CC2)[C@H]3[C@@H](NC(C(NC4=CC=C(Cl)C=N4)=O)=O)CC[C@H](C(N(C)C)=O)C3

Synonyms:

• DU 176b
• Du 176
• Ethanediamide, N-(5-chloro-2-pyridinyl)-N′-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-
• Ethanediamide, N¹-(5-chloro-2-pyridinyl)-N²-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-
• N-(5-Chloro-2-pyridinyl)-N'-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide
• N-(5-Chloropyridin-2-yl)-N′-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide
• N¹-(5-Chloro-2-pyridinyl)-N²-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide
• Edoxaban
• Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-
• N1-(5-Chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide

Edoxaban

CAS: 480449-70-5

Formula: C₂₄H₃₀ClN₇O₄S

Molecular weight: 548.06

Ref: 4Z-E-080091

Edoxaban

CAS: 480449-70-5

Edoxaban

Formula: C₂₄H₃₀ClN₇O₄S

Purity: ≥95%

Molecular weight: 548.06

Ref: 54-BUP06398

Edoxaban

Controlled Product

CAS: 480449-70-5

Formula: C₂₄H₃₀ClN₇O₄S

Color and Shape: Neat

Molecular weight: 548.06

Ref: 86-MM3366.00

Edoxaban

CAS: 480449-70-5

Formula: C₂₄H₃₀ClN₇O₄S

Color and Shape: Neat

Molecular weight: 548.06

Ref: TR-E555520

Edoxaban

CAS: 480449-70-5

Formula: C₂₄H₃₀ClN₇O₄S

Molecular weight: 548.06

Ref: ST-EA-CP-E8000

Edoxaban

CAS: 480449-70-5

Formula: C₂₄H₃₀ClN₇O₄S

Molecular weight: 548.1

Ref: BE-RMCE014000

Edoxaban

CAS: 480449-70-5

Formula: C₂₄H₃₀ClN₇O₄S

Molecular weight: 548.1

Ref: BE-MU-7475

EDOXABAN

CAS: 480449-70-5

Purity: 98%

Color and Shape: Solid

Molecular weight: 548.0599976

Ref: 10-F799088

Edoxaban

CAS: 480449-70-5

Edoxaban: potent, selective FXa inhibitor; Ki 0.561 nM. Used as an oral anticoagulant for stroke prevention, also inhibits thrombin and FIXa.

Formula: C₂₄H₃₀ClN₇O₄S

Purity: 97.67% - 99.92%

Color and Shape: White Solid

Molecular weight: 548.06

Ref: TM-T2368L