CAS 483-04-5

Ajmalicine

Description:

Ajmalicine, also known as raubasine, is an alkaloid derived from the plant species of the genus Rauvolfia, particularly Rauvolfia serpentina. It is characterized by its complex indole structure, which contributes to its pharmacological properties. Ajmalicine exhibits a range of biological activities, including antihypertensive and sedative effects, making it of interest in medicinal chemistry. The compound acts primarily as a peripheral vasodilator and has been studied for its potential in treating hypertension and other cardiovascular conditions. Ajmalicine's mechanism of action involves the inhibition of certain neurotransmitter receptors, which can lead to a decrease in blood pressure. Additionally, it has been noted for its potential neuroprotective effects. The substance is typically found in the form of a white to off-white crystalline powder and is soluble in organic solvents. Due to its bioactive nature, ajmalicine is also a subject of research in the fields of pharmacology and natural product chemistry, exploring its therapeutic potential and safety profile.

Formula: C₂₁H₂₄N₂O₃

InChI: InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1

InChI key: InChIKey=GRTOGORTSDXSFK-XJTZBENFSA-N

SMILES: C(OC)(=O)C=1[C@]2(C[C@]3(C4=C(C=5C(N4)=CC=CC5)CCN3C[C@@]2([C@H](C)OC1)[H])[H])[H]

Synonyms:

• 4H-Indolo[2,3-a]pyrano[3,4-g]quinolizine, oxayohimban-16-carboxylic acid deriv.
• 4H-Indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylic acid, 4a,5,7,8,13,13b,14,14a-octahydro-4-methyl-, methyl ester, (4S,4aR,13bS,14aS)-
• Ajmalicin
• Circolene
• Hydrosarpan
• Isoarteril
• Lamuran
• Methyl (19Alpha)-19-Methyl-16,17-Didehydro-18-Oxayohimban-16-Carboxylate
• Methyl 19-Methyl-16,17-Didehydro-18-Oxayohimban-16-Carboxylate
• NSC 72133
• NSC 95087
• Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (19α)-
• Py-tetrahydroserpentine
• Ranitol
• Raubaserp
• Raubasil
• Raubasin
• Raubasine
• Raumalina
• Rauvasan
• Sarpan
• Tensyl
• Tetrahydroserpentine
• Vincain
• Vincaine
• Vincein
• Vinceine
• δ-Yohimbine

methyl (1S,15R,16S,20S)-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate

CAS: 483-04-5

Formula: C₂₁H₂₄N₂O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 352.4269

Ref: IN-DA00I8RZ

Ajmalicine

CAS: 483-04-5

Ajmalicine

Purity: ≥95%

Molecular weight: 352.43g/mol

Ref: 54-BUP04204

Raubasine

CAS: 483-04-5

Formula: C₂₁H₂₄N₂O₃

Color and Shape: Pale Yellow Solid

Molecular weight: 352.44

Ref: 4Z-R-441

Ajmalicine

CAS: 483-04-5

Ajmalicine (Raubasine): Blocks α1-adrenoceptor, non-competitive nicotine receptor inhibitor (IC50=72.3 μM), anti-hypertensive, sedative.

Formula: C₂₁H₂₄N₂O₃

Purity: 99.5%

Color and Shape: Solid

Molecular weight: 352.43

Ref: TM-T8044

Raubasine

CAS: 483-04-5

Formula: C₂₁H₂₄N₂O₃

Purity: 98%

Molecular weight: 352.434

Ref: BP-BP1376

Ajmalicine

CAS: 483-04-5

Formula: C₂₁H₂₄N₂O₃

Purity: ≥ 98.0%

Color and Shape: White to off-white solid

Molecular weight: 352.43

Ref: 7W-GP5210

Ajmalicine

CAS: 483-04-5

Natural alkaloid

Formula: C₂₁H₂₄N₂O₃

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 352.43

Ref: 5G-82463

Raubasine

CAS: 483-04-5

Applications Antihypertensive, anti-ischemic.
References Caillet, S., et al.: Food Chem., 124, 1699 (2010), Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010), Ferreres, F., et al.: J. Pharm. Biomed. Anal., 51, 65 (2010),

Formula: C₂₁H₂₄N₂O₃

Color and Shape: Neat

Molecular weight: 352.43

Ref: TR-R127000

Raubasine

CAS: 483-04-5

Raubasine is an indole alkaloid, which is naturally sourced from the plant Rauvolfia serpentina as well as other Rauvolfia species. Its mode of action primarily involves the interaction with adrenergic receptors, where it acts as an antagonist. By blocking these receptors, Raubasine influences the sympathetic nervous system, leading to vasodilation and a subsequent hypotensive effect. This mechanism is primarily leveraged in pharmacological research to study cardiovascular effects and sympathetic nervous system modulation.

Formula: C₂₁H₂₄N₂O₃

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 352.43 g/mol

Ref: 3D-FR09934

Ajmalicine (Raubasine) extrapure, 98%

CAS: 483-04-5

Formula: C₂₁H₂₄N₂O₃

Color and Shape: Off - white to pale yellow, Powder

Molecular weight: 352.43

Ref: SR-19339