CAS 483-04-5
:Ajmalicine
Description:
Ajmalicine, also known as raubasine, is an alkaloid derived from the plant species of the genus Rauvolfia, particularly Rauvolfia serpentina. It is characterized by its complex indole structure, which contributes to its pharmacological properties. Ajmalicine exhibits a range of biological activities, including antihypertensive and sedative effects, making it of interest in medicinal chemistry. The compound acts primarily as a peripheral vasodilator and has been studied for its potential in treating hypertension and other cardiovascular conditions. Ajmalicine's mechanism of action involves the inhibition of certain neurotransmitter receptors, which can lead to a decrease in blood pressure. Additionally, it has been noted for its potential neuroprotective effects. The substance is typically found in the form of a white to off-white crystalline powder and is soluble in organic solvents. Due to its bioactive nature, ajmalicine is also a subject of research in the fields of pharmacology and natural product chemistry, exploring its therapeutic potential and safety profile.
Formula:C21H24N2O3
InChI:InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1
InChI key:InChIKey=GRTOGORTSDXSFK-XJTZBENFSA-N
SMILES:C(OC)(=O)C=1[C@]2(C[C@]3(C4=C(C=5C(N4)=CC=CC5)CCN3C[C@@]2([C@H](C)OC1)[H])[H])[H]
Synonyms:- 4H-Indolo[2,3-a]pyrano[3,4-g]quinolizine, oxayohimban-16-carboxylic acid deriv.
- 4H-Indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylic acid, 4a,5,7,8,13,13b,14,14a-octahydro-4-methyl-, methyl ester, (4S,4aR,13bS,14aS)-
- Ajmalicin
- Circolene
- Hydrosarpan
- Isoarteril
- Lamuran
- Methyl (19Alpha)-19-Methyl-16,17-Didehydro-18-Oxayohimban-16-Carboxylate
- Methyl 19-Methyl-16,17-Didehydro-18-Oxayohimban-16-Carboxylate
- NSC 72133
- NSC 95087
- Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (19α)-
- Py-tetrahydroserpentine
- Ranitol
- Raubaserp
- Raubasil
- Raubasin
- Raubasine
- Raumalina
- Rauvasan
- Sarpan
- Tensyl
- Tetrahydroserpentine
- Vincain
- Vincaine
- Vincein
- Vinceine
- δ-Yohimbine
- See more synonyms
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Ajmalicine
CAS:Ajmalicine (Raubasine): Blocks α1-adrenoceptor, non-competitive nicotine receptor inhibitor (IC50=72.3 μM), anti-hypertensive, sedative.Formula:C21H24N2O3Purity:99.5% - 99.89%Color and Shape:Yellow SolidMolecular weight:352.4269Ajmalicine (Standard)
CAS:Ajmalicine (Standard) is a reference standard for research and analysis in studies involving Ajmalicine. Ajmalicine (Raubasine) (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity。Formula:C21H24N2O3Color and Shape:SolidMolecular weight:352.4269Methyl (4S,4aR,13bS,14aS)-4-methyl-4a,5,7,8,13,13b,14,14a-octahydro-4H-indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylate
CAS:Formula:C21H24N2O3Purity:99%Color and Shape:SolidMolecular weight:352.4269Raubasine
CAS:Applications Antihypertensive, anti-ischemic.
References Caillet, S., et al.: Food Chem., 124, 1699 (2010), Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010), Ferreres, F., et al.: J. Pharm. Biomed. Anal., 51, 65 (2010),Formula:C21H24N2O3Color and Shape:NeatMolecular weight:352.43Ajmalicine
CAS:Formula:C21H24N2O3Purity:≥ 98.0%Color and Shape:White to off-white solidMolecular weight:352.43Ajmalicine
CAS:Natural alkaloidFormula:C21H24N2O3Purity:≥ 98.0 % (HPLC)Color and Shape:PowderMolecular weight:352.43Raubasine
CAS:Raubasine is an indole alkaloid, which is naturally sourced from the plant Rauvolfia serpentina as well as other Rauvolfia species. Its mode of action primarily involves the interaction with adrenergic receptors, where it acts as an antagonist. By blocking these receptors, Raubasine influences the sympathetic nervous system, leading to vasodilation and a subsequent hypotensive effect. This mechanism is primarily leveraged in pharmacological research to study cardiovascular effects and sympathetic nervous system modulation.Formula:C21H24N2O3Purity:Min. 95%Color and Shape:SolidMolecular weight:352.43 g/molAjmalicine (Raubasine) extrapure, 98%
CAS:Formula:C21H24N2O3Color and Shape:Off - white to pale yellow, PowderMolecular weight:352.43
![Methyl (4S,4aR,13bS,14aS)-4-methyl-4a,5,7,8,13,13b,14,14a-octahydro-4H-indolo[2,3-a]pyrano[3,4-g]q…](https://static.cymitquimica.com/products/IN/thumb/DA00I8RZ.jpg)
