CAS 483-45-4

Coreximine

Description:

Coreximine, with the CAS number 483-45-4, is a chemical compound that belongs to the class of alkaloids. It is primarily known for its application in the field of pharmacology, particularly as a potential therapeutic agent. Coreximine exhibits a complex molecular structure that contributes to its biological activity, which may include effects on neurotransmitter systems. The compound is typically characterized by its solubility in organic solvents, while its solubility in water may be limited. Coreximine's stability can vary depending on environmental conditions such as pH and temperature. As with many alkaloids, it may possess a range of physiological effects, which necessitates careful handling and consideration of safety protocols in laboratory settings. Research into Coreximine's pharmacological properties continues, with studies focusing on its potential benefits and mechanisms of action. However, detailed information regarding its specific applications, efficacy, and safety profile is still under investigation, highlighting the need for further research in this area.

Formula: C₁₉H₂₁NO₄

InChI: InChI=1S/C19H21NO4/c1-23-18-7-11-3-4-20-10-13-8-19(24-2)16(21)6-12(13)5-15(20)14(11)9-17(18)22/h6-9,15,21-22H,3-5,10H2,1-2H3/t15-/m0/s1

InChI key: InChIKey=BWUQAWCUJMATJS-HNNXBMFYSA-N

SMILES: OC=1C=C2[C@]3(N(CC=4C(C3)=CC(O)=C(OC)C4)CCC2=CC1OC)[H]

Synonyms:

• 6H-Dibenzo[a,g]quinolizine-2,11-diol, 5,8,13,13a-tetrahydro-3,10-dimethoxy-, (S)-
• Coreximine
• 6H-Dibenzo[a,g]quinolizine-2,11-diol, 5,8,13,13a-tetrahydro-3,10-dimethoxy-, (13aS)-
• (13aS)-5,8,13,13a-Tetrahydro-3,10-dimethoxy-6H-dibenzo[a,g]quinolizine-2,11-diol
• 13aα-Berbine-2,11-diol, 3,10-dimethoxy-

(S)-(+)-Coreximine

Controlled Product

CAS: 483-45-4

Applications The S-(+)-enantiomer of Coreximine, an alkaloid found in the opium poppy.

Formula: C₁₉H₂₁NO₄

Color and Shape: Neat

Molecular weight: 327.37

Ref: TR-C687500

(S)-(+)-Coreximine

Controlled Product

CAS: 483-45-4

Coreximine is a hydrogen-bonded drug that inhibits the enzyme dopamine β-hydroxylase, which converts dopamine to norepinephrine. It has been found to be more potent in inhibiting this enzyme than other drugs in its class due to its greater affinity for the active site of the enzyme. Coreximine has shown anticancer activity against thp-1 cells in vitro and is currently being investigated as a potential chemotherapeutic agent. Coreximine has also been shown to induce neuronal death in short-term exposure experiments and induce cardiac glycoside effects. Coreximine's optimum pH level is 7.5, with an optimal concentration of 2 mM at this pH level.

Formula: C₁₉H₂₁NO₄

Purity: Min. 95%

Molecular weight: 327.37 g/mol

Ref: 3D-FC20554