CAS 483-63-6

Crotamiton

Description:

Crotamiton is an organic compound primarily used as a topical medication for the treatment of scabies and other skin conditions. It is classified as a sulfonamide and has both antipruritic (itch-relieving) and scabicidal properties. The chemical structure of crotamiton includes a 4-ethyl-2-methylphenol moiety, which contributes to its pharmacological effects. It is typically formulated as a cream or lotion for direct application to the affected areas of the skin. Crotamiton is known for its relatively low toxicity and is generally well-tolerated, although some individuals may experience skin irritation or allergic reactions. The mechanism of action involves disrupting the nervous system of the scabies mite, leading to its elimination. Additionally, crotamiton is often used in conjunction with other treatments to enhance efficacy. It is important to follow medical guidance when using crotamiton to ensure proper application and to minimize potential side effects. As with any medication, contraindications and interactions with other drugs should be considered.

Formula: C₁₃H₁₇NO

InChI: InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3

InChI key: InChIKey=DNTGGZPQPQTDQF-UHFFFAOYSA-N

SMILES: N(C(C=CC)=O)(CC)C1=C(C)C=CC=C1

Synonyms:

• (2E)-N-ethyl-N-(2-methylphenyl)but-2-enamide
• 2-(acetyloxy)-N,N,N-trimethylethanaminium chloride
• 2-Butenamide, N-ethyl-N-(2-methylphenyl)-
• Crotalgin
• Crotamitex
• Crotamitone
• Crotonyl N-ethyl-o-toluidine
• Eurax
• Euraxil
• N-Crotonyl-N-ethyl-o-toluidine
• N-Ethyl-N-(2-methylphenyl)-2-butenamide
• N-Ethyl-O-Crotonotoluidine
• N-Ethyl-o-crotonotoluidide
• N-Ethyl-o-crotonotoluidide,predominantly trans
• N-ethyl-N-(2-methylphenyl)but-2-enamide
• N-ethyl-N-crotonoyl-2-toluidine
• N-ethylcroton-o-toluidide
• Veteusan
• o-Crotonotoluidide, N-ethyl-

Crotamiton

CAS: 483-63-6

Crotamiton

Formula: C₁₃H₁₇NO

Purity: 99.0%

Color and Shape: Yellow Oily

Molecular weight: 203.13101

Ref: 47-94

CROTAMITON CRS

CAS: 483-63-6

CROTAMITON CRS

Ref: 41-C2970000

CROTAMITON FOR SYSTEM SUITABILITY CRS

CAS: 483-63-6

CROTAMITON FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0002338

Crotamiton

CAS: 483-63-6

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Formula: C₁₃H₁₇NO

Color and Shape: Pale Yellow Liquid

Molecular weight: 203.13101

Ref: 45-1151006

2-Butenamide, N-ethyl-N-(2-methylphenyl)-

CAS: 483-63-6

Formula: C₁₃H₁₇NO

Purity: %

Color and Shape: Liquid

Molecular weight: 203.2802

Ref: IN-DA00I8S0

Crotamiton

CAS: 483-63-6

Crotamiton (Eurax) is an antipruritic and a scabicidal agent available as a lotion or cream for topical use only.

Formula: C₁₃H₁₇NO

Purity: 99.38%

Color and Shape: Liquid

Molecular weight: 203.28

Ref: TM-T0376

Crotamiton-d5 (Mixture of Z and E Isomers)

CAS: 483-63-6

Formula: C₁₃H₁₂D₅NO

Molecular weight: 208.32

Ref: 4Z-C-308007

Crotamiton

CAS: 483-63-6

Crotamiton

Purity: ≥90%

Molecular weight: 203.28g/mol

Ref: 54-BUP18142

N-Ethyl-o-Crotonotoluidine (Crotamiton)

CAS: 483-63-6

N-Ethyl-o-Crotonotoluidine (Crotamiton)

Purity: 95%

Molecular weight: 203.28g/mol

Ref: 54-OR1014365

Crotamiton (Mixture of Z and E Isomers)

CAS: 483-63-6

Formula: C₁₃H₁₇NO

Molecular weight: 203.29

Ref: 4Z-C-308001

Crotamiton

CAS: 483-63-6

Formula: C₁₃H₁₇NO

Purity: ≥ 97.0%

Color and Shape: Clear, colourless to pale yellow liquid

Molecular weight: 203.28

Ref: 7W-GP2631

Crotamiton

CAS: 483-63-6

Formula: C₁₃H₁₇NO

Color and Shape: Neat

Molecular weight: 203.28

Ref: 04-C11754000

Crotamiton

CAS: 483-63-6

N-Ethyl-o-crotonotoluidide is a new drug for the treatment of infectious diseases. It inhibits cox-2 and has been shown to be effective in the treatment of chronic skin infections, such as erythrasma and intertrigo. N-Ethyl-o-crotonotoluidide is also effective against other types of bacteria, including methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. The long term efficacy of N-Ethyl-o-crotonotoluidide in patients with chronic skin infections has not yet been established.

Formula: C₁₃H₁₇NO

Purity: Min. 95%

Color and Shape: Clear Liquid

Molecular weight: 203.28 g/mol

Ref: 3D-FE61444

N-Ethyl-o-crotonotoluidide

CAS: 124236-29-9, 483-63-6

Formula: C₁₃H₁₇NO

Purity: >95.0%(GC)

Color and Shape: Colorless to Light yellow to Light orange clear liquid

Molecular weight: 203.29

Ref: 3B-E0814

CROTAMITON

CAS: 483-63-6

Purity: 97%

Molecular weight: 203.2850037

Ref: 10-F807073

N-Ethyl-N-(o-tolyl)but-2-enamide

CAS: 483-63-6

Formula: C₁₃H₁₇NO

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 203.285

Ref: 10-F516382

Crotamiton (Cis/Trans Mixture)

Controlled Product

CAS: 483-63-6

Stability Light Sensitive
Applications Crotamiton is an anti-parasitic agent. Crotamiton is used both as a scabicidal (for treating scabies) and as a general antipruritic.
References Buffet, M. et al.: Fund. Clin. Pharmacol., 17, 217 (2003); Lemke, T.L.: Foye’s Prin. Med. Chem., 6, 1084 (2008); Dika, E. et al.: Cutan. Ocular Toxicol., 25, 211 (2006);

Formula: C₁₃H₁₇NO

Color and Shape: Neat

Molecular weight: 203.28

Ref: TR-C818005