CAS 483367-10-8

Purmorphamine

Description:

Purmorphamine is a synthetic small molecule that belongs to the class of compounds known as morpholines. It is primarily recognized for its role in promoting osteogenic differentiation, making it of interest in regenerative medicine and stem cell research. Purmorphamine acts as a potent agonist of the Hedgehog signaling pathway, which is crucial for various developmental processes, including bone formation and repair. The compound has been studied for its potential applications in enhancing bone regeneration and treating conditions such as osteoporosis. In terms of its chemical structure, Purmorphamine features a morpholine ring, which contributes to its biological activity. It is typically characterized by its solubility in organic solvents and its stability under standard laboratory conditions. As with many bioactive compounds, careful consideration of its dosage and potential side effects is essential in research and therapeutic contexts. Overall, Purmorphamine represents a significant advancement in the exploration of small molecules for tissue engineering and regenerative therapies.

Formula: C₃₁H₃₂N₆O₂

InChI: InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)

InChI key: InChIKey=FYBHCRQFSFYWPY-UHFFFAOYSA-N

SMILES: N(C1=C2C(N(C=N2)C3CCCCC3)=NC(OC=4C5=C(C=CC4)C=CC=C5)=N1)C6=CC=C(C=C6)N7CCOCC7

Synonyms:

• 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
• 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
• 9H-Purin-6-amine, 9-cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-
• Purmorphamine
• 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthyloxy)-9H-purin-6-amin
• 9-Cyclohexyl-N-[(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
• 9-Cyclohexyl-N-[4-(Morpholin-4-yl)phenyl]-2-(naphthalen-1-yloxy)-9H-purin-6-aMine
• Shh Signaling Antagonist VI
• Purmorphamine, >=98%
• Purmorphamin
• Purmorphamine USP/EP/BP
• Purmorphamine 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
• 9-Cyclohexyl-N-[4-(4-Morpholinyl)phenyl]-2-(1-naphthalenyloxy)-
• CS-1816
• 9-CYCLOHEXYL-N-(4-MORPHOLINOPHENYL)-2-(NAPHTHALEN-1-YLOXY)-9H-PURIN-6-AMINE

Purmorphamine

CAS: 483367-10-8

Formula: C₃₁H₃₂N₆O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 520.6248

Ref: IN-DA006WXR

Purmorphamine

CAS: 483367-10-8

Purmorphamine

Purity: 98%

Molecular weight: 520.62g/mol

Ref: 54-OR1022842

Purmorphamine

CAS: 483367-10-8

Purmorphamine

Purity: ≥95%

Molecular weight: 520.62g/mol

Ref: 54-BUP14393

Purmorphamine

CAS: 483367-10-8

Formula: C₃₁H₃₂N₆O₂

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 520.64

Ref: 3B-P3217

Purmorphamine

CAS: 483367-10-8

Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo.

Formula: C₃₁H₃₂N₆O₂

Purity: 97.19% - 99.48%

Color and Shape: Light Tan Solid

Molecular weight: 520.62

Ref: TM-T1810

Purmorphamine

CAS: 483367-10-8

Formula: C₃₁H₃₂N₆O₂

Molecular weight: 520.64

Ref: 4Z-K-031013

Purmorphamine

Controlled Product

CAS: 483367-10-8

Applications Activates the Hedgehog pathway.
References Cooper, M., et al.: Science, 280, 1603 (1998), Ingham, P., et al.: Genes Dev., 15, 3059 (2001), Beachy, P., et al.: Nature, 432, 324 (2004), Wu, X., et al.: Chem. Biol., 11, 1229 (2004),

Formula: C₃₁H₃₂N₆O₂

Color and Shape: Neat

Molecular weight: 520.62

Ref: TR-P840300

Purmorphamine

CAS: 483367-10-8

Purmorphamine is a cell factor that belongs to the group of morphogens. It is structurally related to dopamine and has been shown to be effective in the treatment of Parkinson's disease. Purmorphamine is involved in the regulation of neuronal survival, differentiation, proliferation, and axon guidance. Purmorphamine binds to a receptor on neurons called the cholinergic receptor, which stimulates a G-protein linked signal transduction pathway. This leads to an increase in intracellular calcium levels and activation of protein kinase C. Purmorphamine also has anti-inflammatory effects and can inhibit leukemia inhibitory factor (LIF). It has been shown to be effective against LPS-induced inflammatory responses by inhibiting protein synthesis. Purmorphamine also inhibits cancer cells through its ability to stimulate growth factor-β1 (GF-β1) gene expression.

Formula: C₃₁H₃₂N₆O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 520.63 g/mol

Ref: 3D-FP27264