CAS 484-78-6

3-Hydroxykynurenine

Description:

3-Hydroxykynurenine is an organic compound that belongs to the kynurenine pathway, which is a significant metabolic route for the amino acid tryptophan. It is characterized by its hydroxyl group (-OH) attached to the aromatic ring of the kynurenine structure, which contributes to its biological activity. This compound is known for its role in various physiological processes, including neuroprotection and modulation of immune responses. It exhibits antioxidant properties, which may help in protecting cells from oxidative stress. Additionally, 3-hydroxykynurenine has been studied for its potential involvement in neurodegenerative diseases, as it can influence neurotransmitter levels and neuronal health. The compound is soluble in water and organic solvents, making it versatile for various biochemical applications. Its CAS number, 484-78-6, is a unique identifier that facilitates its recognition in scientific literature and databases. Overall, 3-hydroxykynurenine is a significant molecule in biochemistry and pharmacology, with ongoing research into its therapeutic potential.

Formula: C₁₀H₁₂N₂O₄

InChI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)

InChI key: InChIKey=VCKPUUFAIGNJHC-UHFFFAOYSA-N

SMILES: C(CC(C(O)=O)N)(=O)C1=C(N)C(O)=CC=C1

Synonyms:

• 2-Amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoicacid
• 3-Hydroxy-<span class="text-smallcaps">DL</span>-kynurenine
• 3-Hydroxykynurenine
• 484-78-6
• <span class="text-smallcaps">DL</span>-3-Hydroxykynurenine
• Alanine, 3-(3-hydroxyanthraniloyl)-
• Benzenebutanoic acid, α,2-diamino-3-hydroxy-γ-oxo-
• Hydroxykynurenine
• α,2-Diamino-3-hydroxy-γ-oxobenzenebutanoic acid

3-Hydroxykynurenine

CAS: 484-78-6

3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.

Formula: C₁₀H₁₂N₂O₄

Purity: 98.83% - 99.89%

Color and Shape: Solid

Molecular weight: 224.2133

Ref: TM-T37683

3-Hydroxykynurenine

CAS: 484-78-6

3-Hydroxykynurenine

Formula: C₁₀H₁₂N₂O₄

Purity: ≥98%

Molecular weight: 224.21

Ref: 54-BUP00738

2-Amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid

CAS: 484-78-6

Formula: C₁₀H₁₂N₂O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 224.2133

Ref: IN-DA006WTI

rac 3-Hydroxy Kynurenine Hydrochloride Salt

Controlled Product

CAS: 484-78-6

Applications 3-Hydroxykynurenine is a metabolite of tryptophan. 3-Hydroxykynurenine filters UV light in the human lens. Studies suggest that Hydroxykynurenine is an endogenous oxidative stress generator and a potential endogenous neurotoxin.
References Malina, H.Z. et al.: Graefes. Arch. Clin. Exp. Ophthalmol., 233, 38 (1995); Okuda, S. et al.: J. Neurochem., 70, 299 (1998);

Formula: C₁₀H₁₂N₂O₄·xHCl

Color and Shape: Neat

Molecular weight: 224.213646

Ref: TR-H943695

rac 3-Hydroxy Kynurenine-13C2,15N Hydrochloride Salt

Controlled Product

CAS: 1391051-70-9, 484-78-6

Stability Hygroscopic
Applications Labelled analogue of 3-Hydroxykynurenine is a metabolite of tryptophan. 3-Hydroxykynurenine filters UV light in the human lens. Studies suggest that Hydroxykynurenine is an endogenous oxidative stress generator and a potential endogenous neurotoxin.
References Malina, H.Z. et al.: Graefes. Arch. Clin. Exp. Ophthalmol., 233, 38 (1995); Okuda, S. et al.: J. Neurochem., 70, 299 (1998);

Formula: C₈₁₃C₂H₁₂N₁₅NO₄·xHCl

Color and Shape: Neat

Molecular weight: 227.193646

Ref: TR-H943697

3-Hydroxy-DL-kynurenine

CAS: 484-78-6

Stability Hygroscopic
Applications 3-Hydroxy-DL-kynurenine is a tryptophan metabolite. Could be associated with symptoms in Parkinson's disease.
References Heilman, P. L., et al.: Movement Disorders, 35, 2028 (2020)

Formula: C₁₀H₁₂N₂O₄

Color and Shape: Neat

Molecular weight: 224.21

Ref: TR-H950758

3-Hydroxykynurenine

CAS: 484-78-6

2-Amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid

Formula: C₁₀H₁₂N₂O₄

Purity: 97%

Molecular weight: 224.21

Ref: IN-DG11997

3-Hydroxy-DL-kynurenine

CAS: 484-78-6

3-Hydroxy-DL-kynurenine is a biochemical compound, which is an intermediate in the kynurenine pathway. This pathway is a major route of tryptophan degradation in the body, highlighting its role in various physiological processes. 3-Hydroxy-DL-kynurenine exerts its effects by participating in redox reactions and influencing cellular oxidative stress. It serves both antioxidant and prooxidant functions, depending on its concentration and specific biological context.

Formula: C₁₀H₁₂N₂O₄

Purity: Min. 98 Area-%

Color and Shape: Brown Yellow Powder

Molecular weight: 224.21 g/mol

Ref: 3D-FH64905

3-hydroxykynurenine-[U-Ring-13C6]

CAS: 484-78-6

Formula: C₁₀H₁₂N₂O₄

Color and Shape: Solid

Molecular weight: 224.21

Ref: BE-MC-7439

3-Hydroxykynurenine

CAS: 484-78-6

Purity: 97%

Molecular weight: 224.08

Ref: 10-F866323