CAS 486-56-6
:Cotinine
Description:
Cotinine is a naturally occurring alkaloid and a major metabolite of nicotine, primarily found in tobacco. It is classified as a pyridine derivative and has a molecular formula of C10H12N2O. Cotinine is typically a colorless to pale yellow liquid with a characteristic odor and is soluble in water, alcohol, and organic solvents. Its structure features a pyridine ring, which contributes to its pharmacological properties. Cotinine is often used as a biomarker for tobacco exposure due to its relatively long half-life compared to nicotine, making it useful in studies related to smoking cessation and tobacco use. The substance exhibits mild psychoactive effects and has been studied for its potential therapeutic applications, including neuroprotective properties. Additionally, cotinine has been investigated for its role in modulating the effects of nicotine on the central nervous system. Safety data indicate that cotinine has low toxicity, but its effects can vary based on dosage and individual sensitivity.
Formula:C10H12N2O
InChI:InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1
InChI key:InChIKey=UIKROCXWUNQSPJ-VIFPVBQESA-N
SMILES:CN1[C@@H](CCC1=O)C=2C=CC=NC2
Synonyms:- (5R)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
- (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
- (5S)-1-Methyl-5-pyridin-3-ylpyrrolidin-2-one
- (5S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
- (S)-(-)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone
- (S)-Cotinine
- 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (5S)-
- 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (S)-
- Cotinin
- Cotinina
- Nih 10498
- Cotinine
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 20 products.
Nicotine Related Compound C ((S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one)
CAS:Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoiFormula:C10H12N2OColor and Shape:White Off-White PowderMolecular weight:176.09496Ref: IN-DA00DEPD
1g536.00€10gTo inquire25gTo inquire50gTo inquire5mg37.00€25mg65.00€100mg118.00€250mg190.00€Cotinine
CAS:Cotinine (NIH-10498) is an alkaloid found in tobacco and is also the predominant metabolite of nicotine.Formula:C10H12N2OPurity:98% - 99.89%Color and Shape:Viscous Oil SolidMolecular weight:176.22S-(-)-Cotinine
CAS:S-(-)-CotinineFormula:C10H12N2OPurity:≥95%Color and Shape: pale orange low melting solidMolecular weight:176.22g/molCotinine (Nicotine EP Impurity C, Nicotine USP Related Compound C)
CAS:Formula:C10H12N2OColor and Shape:Colorless LiquidMolecular weight:176.22(5S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one ((-)-Cotinine)
CAS:Controlled ProductFormula:C10H12N2OColor and Shape:NeatMolecular weight:176.22(-)-Cotinine 100 µg/mL in Acetonitrile
CAS:Formula:C10H12N2OColor and Shape:Single SolutionMolecular weight:176.22S-(-)-Cotinine
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications S-(-)-Cotinine is a major metabolite of Nicotine (N412450) in humans. It is a carcinogen.This compound is a contaminant of emerging concern (CECs)<br>References Thompson, J.A., et al.: J. Chromatog., 231, 53 (1982); Seeman, J.I., et al.: J. Org. Chem., 51, 1548 (1986); Nakajima, M., et al.: Drug Metab. Dispos., 24, 1212 (1996)<br></p>Formula:C10H12N2OColor and Shape:NeatMolecular weight:176.22(S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one
CAS:Formula:C10H12N2OPurity:≥98%Molecular weight:176.219S-(-)-Cotinine (1 mg/mL in Methanol)
CAS:Formula:C10H12N2OColor and Shape:Single SolutionMolecular weight:176.22S-(-)-Cotinine
CAS:<p>Cotinine is a metabolite of nicotine that is found in the blood. It is used as a biomarker for exposure to tobacco products and has been shown to be an independent risk factor for cardiovascular disease. Cotinine can be detected in the blood, plasma, saliva, urine and breast milk with detection times of 24 hours to one week. Cotinine can also be measured in hair samples with detection times of 80 days or more. The measurement of cotinine levels in biological samples is complicated by the presence of other metabolites from nicotine metabolism and its high affinity for proteins such as albumin. It is important to account for these confounding factors when interpreting results from cotinine measurements. The most common method used to measure cotinine levels in biological samples is liquid chromatography-mass spectrometry (LC-MS/MS). This analytical method uses a mass spectrometer to separate and identify molecules based on their mass-to-charge ratio. A mouse monoclonal antibody</p>Formula:C10H12N2OPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:176.22 g/mol(-)-Cotinine, 98%
CAS:<p>(-)-Cotinine is used to activate a subpopulation of 3/ 62 nAChRs in monkey striatum. It binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodege</p>Formula:C10H12N2OPurity:98%Color and Shape:White to cream to yellow to pale brown, Fused solid : Clear liquid as meltMolecular weight:176.22
