CAS 486-56-6: Cotinine

Description: Cotinine is a naturally occurring alkaloid and a major metabolite of nicotine, primarily found in tobacco. It is classified as a pyridine derivative and has a molecular formula of C10H12N2O. Cotinine is typically a colorless to pale yellow liquid with a characteristic odor and is soluble in water, alcohol, and organic solvents. Its structure features a pyridine ring, which contributes to its pharmacological properties. Cotinine is often used as a biomarker for tobacco exposure due to its relatively long half-life compared to nicotine, making it useful in studies related to smoking cessation and tobacco use. The substance exhibits mild psychoactive effects and has been studied for its potential therapeutic applications, including neuroprotective properties. Additionally, cotinine has been investigated for its role in modulating the effects of nicotine on the central nervous system. Safety data indicate that cotinine has low toxicity, but its effects can vary based on dosage and individual sensitivity.

Formula: C₁₀H₁₂N₂O

InChI: InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1

InChI key: InChIKey=UIKROCXWUNQSPJ-VIFPVBQESA-N

SMILES: O=C1N(C)C(C=2C=NC=CC2)CC1

Synonyms:

• (5R)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
• (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
• (5S)-1-Methyl-5-pyridin-3-ylpyrrolidin-2-one
• (5S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
• (S)-(-)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone
• (S)-Cotinine
• 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (5S)-
• 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (S)-
• Cotinin
• Cotinina
• Nih 10498
• Cotinine
• (-)-Cotinine

(-)-Cotinine, 98%

CAS: 486-56-6

(-)-Cotinine is used to activate a subpopulation of α3/ α6β2 nAChRs in monkey striatum. It …

• Formula: C₁₀H₁₂N₂O
• Purity: 98%
• Color and Shape: White to cream to yellow to pale brown, Fused solid : Clear liquid as melt
• Molecular weight: 176.22

Nicotine impurity standard

CAS: 486-56-6491-26-9 51095-86-4 532-12-7 6019-06-3

• Color and Shape: Off-White

Nicotine Related Compound C ((S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one)

CAS: 486-56-6

Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoi

• Formula: C₁₀H₁₂N₂O
• Color and Shape: White Off-White Powder
• Molecular weight: 176.09496

(-)-COTININE

CAS: 486-56-6

• Formula: C₁₀H₁₂N₂O
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 176.21508000000009

Cotinine

CAS: 486-56-6

Cotinine (NIH-10498) is an alkaloid found in tobacco and is also the predominant metabolite of …

• Formula: C₁₀H₁₂N₂O
• Purity: 98% - 99.89%
• Color and Shape: Viscous Oil Solid
• Molecular weight: 176.22

(-)-Cotinine

CAS: 486-56-6

• Formula: C₁₀H₁₂N₂O
• Molecular weight: 176.22

(-)-Cotinine (Nicotine EP Impurity C, Nicotine USP Related Compound C)

CAS: 486-56-6

• Formula: C₁₀H₁₂N₂O
• Color and Shape: Colorless Liquid
• Molecular weight: 176.22

S-(-)-Cotinine

CAS: 486-56-6

• Formula: C₁₀H₁₂N₂O
• Purity: By gc: 99.17% by area (Typical Value in Batch COA)
• Color and Shape: pale orange low melting solid
• Molecular weight: 176.22g/mol

(-)-Cotinine 100 µg/mL in Acetonitrile

CAS: 486-56-6

• Formula: C₁₀H₁₂N₂O
• Color and Shape: Single Solution
• Molecular weight: 176.22

(5S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one ((-)-Cotinine)

CAS: 486-56-6

• Formula: C₁₀H₁₂N₂O
• Color and Shape: Neat
• Molecular weight: 176.22

(-)-Cotinine

CAS: 486-56-6

• Formula: C₁₀H₁₂N₂O
• Color and Shape: Neat
• Molecular weight: 176.22

(S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one

CAS: 486-56-6

• Purity: 95.0%
• Molecular weight: 176.218994140625

S-(-)-Cotinine

CAS: 486-56-6

Stability Hygroscopic Applications S-(-)-Cotinine is a major metabolite of Nicotine (N412450) in humans. It is …

• Formula: C₁₀H₁₂N₂O
• Color and Shape: Colourless To Dark Orange
• Molecular weight: 176.22

S-(-)-Cotinine (1.0 mg/mL in Methanol)

CAS: 486-56-6

• Formula: C₁₀H₁₂N₂O
• Color and Shape: Single Solution
• Molecular weight: 176.22

S-(-)-Cotinine

CAS: 486-56-6

Please enquire for more information about S-(-)-Cotinine including the price, delivery time and more detailed …

• Formula: C₁₀H₁₂N₂O
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 176.22 g/mol

Nicotine EP Impurity C (Nicotine USP Related Compound C)

CAS: 486-56-6

• Formula: C₁₀H₁₂N₂O
• Color and Shape: Off-White Solid
• Molecular weight: 176.22

(−)-Cotinine solution, 1.0 mg/mL in methanol, ampule of 1 mL

CAS: 486-56-6

Cotinine is a major metabolite of nicotine that can be detected in blood, saliva, and …

• Formula: C₁₀H₁₂N₂O
• Purity: Min. 95%
• Molecular weight: 176.22 g/mol