CAS 486-84-0

Harman

Description:

Harman, with the CAS number 486-84-0, is an indole alkaloid that is primarily derived from the seeds of various plants, particularly those in the legume family. It is known for its psychoactive properties and is often studied for its potential effects on the central nervous system. Harman exhibits a molecular structure characterized by a fused benzene and pyrrole ring, contributing to its aromatic properties. It is typically found in trace amounts in certain foods, such as cooked meats and some alcoholic beverages, and is also a product of the Maillard reaction, which occurs during cooking. Harman has garnered interest in pharmacology due to its potential role as a monoamine oxidase inhibitor (MAOI), which may influence mood and cognitive functions. Additionally, it has been investigated for its antioxidant properties. However, its psychoactive effects necessitate caution, as they can vary based on dosage and individual sensitivity. Overall, harman represents a fascinating compound within the realm of natural products and their biological implications.

Formula: C₁₂H₁₀N₂

InChI: InChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3

InChI key: InChIKey=PSFDQSOCUJVVGF-UHFFFAOYSA-N

SMILES: CC1=C2C(C=3C(N2)=CC=CC3)=CC=N1

Synonyms:

• 1-Methyl-9H-pyrido[3,4-b]indole
• 1-Methyl-9H-β-carboline
• 1-Methyl-β-carboline
• 1-methyl-9H-beta-carboline
• 2,9-Pyridindole, 1-methyl-
• 2-Methyl-?carboline
• 9H-Pyrido[3,4-b]indole, 1-methyl-
• Aribin
• Aribine
• Aribine~1-Methyl-9H-pyrido[3,4-b]indole
• Harman
• Indoter
• Locuturin
• Locuturine
• NSC 54439

1-Methyl-9H-pyrido[3,4-b]indole

CAS: 486-84-0

Formula: C₁₂H₁₀N₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 182.2212

Ref: IN-DA003QU1

Harmane

CAS: 486-84-0

Harmane

Purity: ≥95%

Molecular weight: 182.22g/mol

Ref: 54-BUP14739

Harman

CAS: 486-84-0

Formula: C₁₂H₁₀N₂

Molecular weight: 182.23

Ref: 4Z-H-104001

1-Methyl-9H-Pyrido[3,4-B]Indole

CAS: 486-84-0

1-Methyl-9H-Pyrido[3,4-B]Indole

Purity: 99%

Molecular weight: 182.22g/mol

Ref: 54-OR1009535

Harmane

CAS: 486-84-0

Formula: C₁₂H₁₀N₂

Molecular weight: 182.22

Ref: 7W-GP4080

1-methyl-9H-β-carboline

CAS: 486-84-0

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 182.2259979248047

Ref: 10-F367646

Harmane

Controlled Product

CAS: 486-84-0

Formula: C₁₂H₁₀N₂

Color and Shape: Neat

Molecular weight: 182.22

Ref: 04-C14096000

Harmane

CAS: 486-84-0

Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.

Formula: C₁₂H₁₀N₂

Purity: 97.89% - >99.99%

Color and Shape: Off-White Solid

Molecular weight: 182.22

Ref: TM-T3158

Harman

CAS: 486-84-0

Applications Harman alkaloid like harmane, harmine, harmalol, harmaline obtained from Banisteriopsis caapi L. showed cytotoxicity, antimicrobial activity against Staphylococcus aureus, Escherichia coli, Proteus vulgaris and Candida albicans.
References Sigg, E.B., et al.: Arch. Int. Pharmacodyn., 149, 164 (1964), Saano, V., et al.: Acta Pharmacol. Toxicol., 51, 300 (1982), Tse, S., et al.: Biochem. Pharmacol., 42, 459 (1991), Rommelspacher, H., et al.: Eur. J. Pharmacol., 252, 51 (1994), Louis, E., et al.: Neurology, 59, 1940 (2002),

Formula: C₁₂H₁₀N₂

Color and Shape: White To Dark Brown

Molecular weight: 182.22

Ref: TR-H105000

Harman

CAS: 486-84-0

Harman is a naturally occurring indole alkaloid that is structurally similar to the neurotransmitter serotonin. It has been shown to have inhibitory properties on mammalian cells, such as cytosolic Ca2+ levels, and to act as an inhibitor molecule against chemical pesticides. Harman has also been shown to be a competitive inhibitor of human serum albumin, with a Kd value of 1.3 μM.
Harmane is synthesized from tryptophan by the enzyme indoleamine dioxygenase (IDO). The synthesis of harmane from tryptophan is catalyzed by IDO in the presence of molecular oxygen. The first step in this reaction involves the conversion of tryptophan into N-formylkynurenine by the enzyme tryptophan 2,3-dioxygenase (TDO). In the second step, IDO converts N-formylkynurenine into N-form

Formula: C₁₂H₁₀N₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 182.22 g/mol

Ref: 3D-FH23738

Harmane, free base

CAS: 486-84-0

Harmane is a chemical with the molecular formula C 10 H 13 NO. It can be used as a versatile building block for organic synthesis, or as an intermediate in the production of other chemicals such as pharmaceuticals and pesticides. Harmane is also used in research involving complex compounds and drug discovery. The CAS number for harmane is 486-84-0.

Formula: C₁₂H₁₀N₂

Molecular weight: 182.23 g/mol

Ref: 3D-H-1150

Harmane

CAS: 486-84-0

Formula: C₁₂H₁₀N₂

Molecular weight: 182.23

Ref: 4Z-H-152