CAS 486-84-0
:Harman
Description:
Harman, with the CAS number 486-84-0, is an indole alkaloid that is primarily derived from the seeds of various plants, particularly those in the legume family. It is known for its psychoactive properties and is often studied for its potential effects on the central nervous system. Harman exhibits a molecular structure characterized by a fused benzene and pyrrole ring, contributing to its aromatic properties. It is typically found in trace amounts in certain foods, such as cooked meats and some alcoholic beverages, and is also a product of the Maillard reaction, which occurs during cooking. Harman has garnered interest in pharmacology due to its potential role as a monoamine oxidase inhibitor (MAOI), which may influence mood and cognitive functions. Additionally, it has been investigated for its antioxidant properties. However, its psychoactive effects necessitate caution, as they can vary based on dosage and individual sensitivity. Overall, harman represents a fascinating compound within the realm of natural products and their biological implications.
Formula:C12H10N2
InChI:InChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3
InChI key:InChIKey=PSFDQSOCUJVVGF-UHFFFAOYSA-N
SMILES:CC1=C2C(C=3C(N2)=CC=CC3)=CC=N1
Synonyms:- 1-Methyl-9H-pyrido[3,4-b]indole
- 1-Methyl-9H-β-carboline
- 1-Methyl-β-carboline
- 1-methyl-9H-beta-carboline
- 2,9-Pyridindole, 1-methyl-
- 2-Methyl-?carboline
- 9H-Pyrido[3,4-b]indole, 1-methyl-
- Aribin
- Aribine
- Aribine~1-Methyl-9H-pyrido[3,4-b]indole
- Harman
- Indoter
- Locuturin
- Locuturine
- NSC 54439
- See more synonyms
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1-Methyl-9H-Pyrido[3,4-B]Indole
CAS:1-Methyl-9H-Pyrido[3,4-B]IndoleFormula:C12H10N2Purity:>99%Molecular weight:182.22Harman
CAS:Applications Harman alkaloid like harmane, harmine, harmalol, harmaline obtained from Banisteriopsis caapi L. showed cytotoxicity, antimicrobial activity against Staphylococcus aureus, Escherichia coli, Proteus vulgaris and Candida albicans.
References Sigg, E.B., et al.: Arch. Int. Pharmacodyn., 149, 164 (1964), Saano, V., et al.: Acta Pharmacol. Toxicol., 51, 300 (1982), Tse, S., et al.: Biochem. Pharmacol., 42, 459 (1991), Rommelspacher, H., et al.: Eur. J. Pharmacol., 252, 51 (1994), Louis, E., et al.: Neurology, 59, 1940 (2002),Formula:C12H10N2Color and Shape:NeatMolecular weight:182.22Harmane
CAS:Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.Formula:C12H10N2Purity:97.89% - >99.99%Color and Shape:SolidMolecular weight:182.2212Harman
CAS:Harman is a naturally occurring indole alkaloid that is structurally similar to the neurotransmitter serotonin. It has been shown to have inhibitory properties on mammalian cells, such as cytosolic Ca2+ levels, and to act as an inhibitor molecule against chemical pesticides. Harman has also been shown to be a competitive inhibitor of human serum albumin, with a Kd value of 1.3 μM. Harmane is synthesized from tryptophan by the enzyme indoleamine dioxygenase (IDO). The synthesis of harmane from tryptophan is catalyzed by IDO in the presence of molecular oxygen. The first step in this reaction involves the conversion of tryptophan into N-formylkynurenine by the enzyme tryptophan 2,3-dioxygenase (TDO). In the second step, IDO converts N-formylkynurenine into N-formFormula:C12H10N2Purity:Min. 95%Color and Shape:PowderMolecular weight:182.22 g/mol1-methyl-9H-beta-carboline
CAS:Formula:C12H10N2Purity:95%Color and Shape:SolidMolecular weight:182.226Harmane (Standard)
CAS:Harmane (Standard) is a reference standard for research and analysis in studies involving Harmane. Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.Formula:C12H10N2Color and Shape:SolidMolecular weight:182.2212
