CAS 487021-52-3

1-(4-Methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea

Description:

1-(4-Methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea is a chemical compound characterized by its unique structural features, which include a urea functional group, a methoxybenzyl moiety, and a nitro-substituted thiazole ring. This compound typically exhibits moderate to high solubility in organic solvents, while its solubility in water may vary depending on pH and temperature. The presence of the nitro group suggests potential for biological activity, often associated with antimicrobial or anticancer properties. The thiazole ring contributes to the compound's reactivity and may influence its interaction with biological targets. Additionally, the methoxy group can enhance lipophilicity, potentially affecting the compound's pharmacokinetics. Overall, this compound's characteristics make it of interest in medicinal chemistry and drug development, particularly in the search for novel therapeutic agents. As with any chemical substance, safety and handling precautions should be observed, given the potential toxicity associated with nitro and thiazole-containing compounds.

Formula: C₁₂H₁₂N₄O₄S

InChI: InChI=1/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)

SMILES: COc1ccc(cc1)CN=C(Nc1ncc(N(=O)=O)s1)O

Synonyms:

• N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea
• Urea, N-[(4-methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)-
• Ar-A014418

1-[(4-Methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea

CAS: 487021-52-3

Formula: C₁₂H₁₂N₄O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 308.3131

Ref: IN-DA00DB4T

AR-A014418

CAS: 487021-52-3

AR-A014418

Purity: ≥95%

Molecular weight: 308.31g/mol

Ref: 54-BUP10691

AR-A014418

CAS: 487021-52-3

Formula: C₁₂H₁₂N₄O₄S

Molecular weight: 308.31

Ref: 7W-GL9664

AR-A014418

CAS: 487021-52-3

AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.

Formula: C₁₂H₁₂N₄O₄S

Purity: >99.99% - ≥95%

Color and Shape: Solid

Molecular weight: 308.31

Ref: TM-T1881

AR-AO 14418

Controlled Product

CAS: 487021-52-3

Applications AR-AO 14418 is a glycogen synthase kinase 3β (GSK-3β) inhibitor (1,2,3). GSK-3β is a serine/threonine protein kinase that is involved numerous diseases such as type II diabetes and Alzheimer's.
References (1) Koh, S., et al.:Toxicol., 247, 112 (2008) (2) Vadivelan, S., et al.: Eur. J. Med. Chem., 44, 2361 (2009) (3) Min, W., et al.: Neuropharmacol., 56, 463 (2009)

Formula: C₁₂H₁₂N₄O₄S

Color and Shape: Neat

Molecular weight: 308.31

Ref: TR-A765500

AR-AO 14418

CAS: 487021-52-3

Inhibitor of GSK3β kinase

Formula: C₁₂H₁₂N₄O₄S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 308.31 g/mol

Ref: 3D-FA17968