CAS 4929-23-1

BI-0115

CAS: 4929-23-1

BI-0115

Purity: ≥98%

Molecular weight: 287.74g/mol

Ref: 54-BUP03166

BI-0115

CAS: 4929-23-1

BI-0115 inhibits LOX-1, preventing oxLDL uptake by triggering receptor inhibition and dimer formation.

Formula: C₁₅H₁₄ClN₃O

Purity: 99.34%

Color and Shape: Solid

Molecular weight: 287.74

Ref: TM-T9108

9-Chloro-5,11-dihydro-5-propyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

CAS: 4929-23-1

BI-0115 is a highly selective inhibitor for the lectin-like oxidised low-density lipoproteins (LDL) receptor 1 (LOX-1). In vitro, BI-0115 inhibits internalisation of oxidised LDL (oxLDL) with IC50 of 5.4?µM. The crystal studies revealed that BI-0115 glues two LOX-1 dimers together, resulting in blocked access of oxLDL. LOX-1 is a Ctype lectin-like receptor expressed on endothelial cells, macrophages and vascular smooth muscle. It is responsible for the regulation, internalisation and degradation of oxidised low-density lipoproteins (oxLDL). BI-0115 is a novel inhibitor to LOX-1 and is a valuable tool to study LOX-1 biology, and their role in diseases, such as, cancer and atheroschelerosis.

Formula: C₁₅H₁₄ClN₃O

Purity: Min. 98 Area-%

Color and Shape: Yellow Powder

Molecular weight: 287.87 g/mol

Ref: 3D-BB178547

9-Chloro-5,11-dihydro-5-propyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Controlled Product

CAS: 4929-23-1

Formula: C₁₅H₁₄ClN₃O

Color and Shape: Neat

Molecular weight: 287.744

Ref: TR-C492920