CAS 496775-61-2

Eltrombopag

Description:

Eltrombopag is a synthetic, small-molecule thrombopoietin receptor agonist primarily used in the treatment of thrombocytopenia, particularly in patients with chronic immune thrombocytopenic purpura (ITP) and those undergoing certain types of chemotherapy. Its chemical formula is C20H22N2O3S, and it features a thiazole ring, which is integral to its mechanism of action. Eltrombopag works by stimulating the bone marrow to increase platelet production, thereby helping to raise platelet counts in patients with low levels. The compound is characterized by its oral bioavailability and a relatively long half-life, allowing for once-daily dosing. It is important to monitor liver function and platelet counts during treatment due to potential side effects, including hepatotoxicity and thromboembolic events. Eltrombopag is marketed under various brand names and is often prescribed when other treatments for low platelet counts are ineffective. As with any medication, it is essential to consider contraindications and interactions with other drugs.

Formula: C₂₅H₂₂N₄O₄

InChI: InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-

InChI key: InChIKey=XDXWLKQMMKQXPV-QYQHSDTDSA-N

SMILES: O=C/1N(N=C(C)\C1=N\NC2=C(O)C(=CC=C2)C3=CC(C(O)=O)=CC=C3)C4=CC(C)=C(C)C=C4

Synonyms:

• 3'-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
• 3′-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2′-hydroxy[1,1′-biphenyl]-3-carboxylic acid
• Sb 497115
• [1,1′-Biphenyl]-3-carboxylic acid, 3′-[(2Z)-2-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2′-hydroxy-
• [1,1′-Biphenyl]-3-carboxylic acid, 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-
• Eltrombopag

Eltrombopag

CAS: 496775-61-2

Formula: C₂₅H₂₂N₄O₄

Purity: %

Color and Shape: Solid

Molecular weight: 442.4666

Ref: IN-DA00DA6A

Eltrombopag

CAS: 496775-61-2

Eltrombopag

Purity: 99%

Molecular weight: 442.47g/mol

Ref: 54-OR1027458

Eltrombopag-13C4

CAS: 1217230-31-3, 496775-61-2

Formula: C₂₁₁₃C₄H₂₂N₄O₄

Color and Shape: Orange-Yellow Solid

Molecular weight: 446.43

Ref: 4Z-E-482

Eltrombopag

CAS: 496775-61-2

Eltrombopag

Purity: ≥98%

Molecular weight: 442.47g/mol

Ref: 54-BUP15498

Eltrombopag

CAS: 496775-61-2

Formula: C₂₅H₂₂N₄O₄

Color and Shape: Orange Solid

Molecular weight: 442.48

Ref: 4Z-E-481

Eltrombopag

CAS: 496775-61-2

Formula: C₂₅H₂₂N₄O₄

Molecular weight: 442.47

Ref: 7W-GP0470

Eltrombopag

CAS: 496775-61-2

Eltrombopag (SB-497115-GR), an orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity, binds to and stimulates the platelet

Formula: C₂₅H₂₂N₄O₄

Purity: 99.27%

Color and Shape: Orange To Red Solid

Molecular weight: 442.47

Ref: TM-T2562

Eltrombopag

Controlled Product

CAS: 496775-61-2

Formula: C₂₅H₂₂N₄O₄

Color and Shape: Orange

Molecular weight: 442.47

Ref: TR-E508000

Eltrombopag

CAS: 496775-61-2

Agonist of thrombopoietin receptor TpoR, which triggers activation of the JAK2/STAT5 signalling pathway. Eltrombopag is indicated in individuals with thrombocytopenia since it leads to increased proliferation of megakaryocyte progenitor cells and increased production of platelets. Eltrombopag also enhances expansion of human umbilical cord blood hematopoietic stem/primitive progenitor cells and promotes hematopoiesis.

Formula: C₂₅H₂₂N₄O₄

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 442.47 g/mol

Ref: 3D-FE22658

Eltrombopag - Bio-X ™

CAS: 496775-61-2

Eltrombopag is an agonist of thrombopoietin receptor TpoR, which triggers activation of the JAK2/STAT5 signalling pathway. This drug is indicated in individuals with thrombocytopenia since it leads to increased proliferation of megakaryocyte progenitor cells and increased production of platelets. Eltrombopag also enhances expansion of human umbilical cord blood hematopoietic stem/primitive progenitor cells and promotes hematopoiesis.

Formula: C₂₅H₂₂N₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 442.47 g/mol

Ref: 3D-BE164406

Eltrombopag-d9

Controlled Product

CAS: 496775-61-2

Formula: C₂₅D₉H₁₃N₄O₄

Color and Shape: Neat

Molecular weight: 451.522

Ref: TR-E508004

Eltrombopag-d3

Controlled Product

CAS: 496775-61-2

Applications Eltrombopag-d3 is an isotopic analog of Eltrombopag (E508000) which is an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.
References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),

Formula: C₂₅D₃H₁₉N₄O₄

Color and Shape: Neat

Molecular weight: 445.485

Ref: TR-E508003