CAS 49863-47-0: Geneticin

Description: Geneticin, also known as G418, is an aminoglycoside antibiotic commonly used in molecular biology as a selection agent for cells that have been genetically modified to express specific resistance genes. Its CAS number is 49863-47-0. Geneticin is particularly effective against eukaryotic cells, making it a valuable tool in the selection of transfected cells that have incorporated plasmids containing the neomycin resistance gene. The compound works by inhibiting protein synthesis, leading to cell death in non-resistant cells. Geneticin is typically used in cell culture at varying concentrations, depending on the cell type and the specific experimental conditions. It is important to handle Geneticin with care, as it can be toxic to both target and non-target cells if not used appropriately. Additionally, its stability and solubility in aqueous solutions make it suitable for various laboratory applications. Overall, Geneticin plays a crucial role in genetic engineering and cell biology research, facilitating the study of gene function and the development of genetically modified organisms.

Formula: C₂₀H₄₀N₄O₁₀

InChI: InChI=1S/C20H40N4O10/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19/h6-19,24-30H,4-5,21-23H2,1-3H3/t6-,7+,8-,9-,10-,11+,12+,13-,14-,15-,16+,17-,18-,19-,20+/m1/s1

InChI key: InChIKey=BRZYSWJRSDMWLG-DJWUNRQOSA-N

SMILES: OC(C)C1OC(OC2C(O)C(OC3OCC(O)(C)C(NC)C3O)C(N)CC2N)C(N)C(O)C1O

Synonyms:

• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-amino-2,7-dideoxy-<smallcap>D</smallcap>-glycero-α-<smallcap>D</smallcap>-gluco-heptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-2-deoxy-
• Antibiotic G 418
• G 418
• G418
• Geneticin
• O-2-Amino-2,7-dideoxy-<span class="text-smallcaps">D</smallcap>-glycero-α-<smallcap>D</smallcap>-gluco-heptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</smallcap>-arabinopyranosyl-(1→6)]-2-deoxy-<smallcap>D</span>-streptamine
• D-Streptamine, O-2-amino-2,7-dideoxy-D-glycero-α-D-gluco-heptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-
• O-2-Amino-2,7-dideoxy-D-glycero-α-D-gluco-heptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-D-streptamine

G418

CAS: 49863-47-0

• Formula: C₂₀H₄₀N₄O₁₀
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 496.5524

G-418

CAS: 49863-47-0

G-418, or Geneticin, is an aminoglycoside antibiotic similar to gentamicin; it's toxic to all cells …

• Formula: C₂₀H₄₀N₄O₁₀
• Color and Shape: Liquid
• Molecular weight: 496.55

G418 Disulfate

CAS: 108321-42-2 49863-47-0

• Formula: C₂₀H₄₀N₄O₁₀·2H₂SO₄
• Purity: >90.0%(HPLC)(N)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 692.70