CAS 50-27-1

Estriol

Description:

Estriol, with the CAS number 50-27-1, is a naturally occurring estrogen and one of the three main estrogens produced by the human body, alongside estradiol and estrone. It is primarily synthesized in the placenta during pregnancy and plays a crucial role in maintaining pregnancy and fetal development. Estriol is characterized by its relatively weak estrogenic activity compared to estradiol and estrone, making it less potent in stimulating estrogen receptors. Chemically, it is a steroid hormone with a molecular formula of C18H24O3, featuring a phenolic structure that contributes to its biological activity. Estriol is often used in hormone replacement therapy, particularly for menopausal symptoms, and is also studied for its potential protective effects against certain hormone-related cancers. Its pharmacokinetics involve rapid metabolism and excretion, primarily through the liver. Due to its specific role in reproductive health, estriol levels are monitored during pregnancy and can be indicative of fetal well-being.

Formula: C₁₈H₂₄O₃

InChI: InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1

InChI key: InChIKey=PROQIPRRNZUXQM-ZXXIGWHRSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(C[C@@H](O)[C@@H]2O)[H]

Synonyms:

• (16Alpha,17Beta)-Estra-1,3,5(10)-Triene-3,16,17-Triol
• (16α,17β)-Estra-1,3,5(10)-triene-3,16,17-triol
• (8R,13S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
• 1,3,5 (10)-Estratriene-3, 16α, 17β-triol
• 1,3,5(10)-Estratriene-3,16a,17b-triol
• 13β-Methyl-1,3,5(10)-gonatriene-3,16α,17β-triol
• 16α,17β-Estriol
• 16α-Estriol
• 16α-Hydroxyestradiol
• 3,16α,17β-Estriol
• 3,16α,17β-Trihydroxyestra-1,3,5(10)-triene
• Aacifemine
• Colpogyn
• Destriol
• ESTRA-1,3,5(10)-TRIENE-3,16α,17β-TRIOL
• Estra-1,3,5(10)-triene-3,16,17-triol, (16α,17β)-
• Estra-1,3,5(10)-triene-3,16alpha,17beta-triol
• Estratriol
• Estriel
• Follicular hormone hydrate
• Gynasan
• Holin V
• Hormomed
• Incurin
• Klimax E
• Klimoral
• Nsc 12169
• OE3
• OE₃
• Oekolp
• Oestriol
• Ortho-Gynest
• Ovesterin
• Ovestin
• Ovestrion
• Ovo-Vinces
• Theelol
• Tridestrin
• Trihydroxyestrin
• Triovex

Estriol

CAS: 50-27-1

Purity: 98.0%

Molecular weight: 288.3869934082031

Ref: 10-F373692

Estriol

Controlled Product

CAS: 50-27-1

Applications A metabolite of Estradiol (E888000). An estrogenic metabolite considerably less potent than the hormone Estradiol (E888000).
References Marrian, et al.: Biochem. J., 23,1090 (1929), Huffman, et al.: J. Biol. Chem., 169, 167 (1947),

Formula: C₁₈H₂₄O₃

Color and Shape: White To Off-White

Molecular weight: 288.38

Ref: TR-E888960

Estriol

Controlled Product

CAS: 50-27-1

Estriol is a steroidal estrogen, which is a naturally occurring hormone primarily sourced from the placenta during pregnancy. Its mode of action involves binding to estrogen receptors, thereby exerting its effects as part of the broader group of estrogens. Estriol has a relatively lower affinity for estrogen receptors compared to estradiol, contributing to its unique pharmacological profile.In scientific research and clinical settings, Estriol is employed in hormone replacement therapy, especially in postmenopausal women, due to its milder estrogenic effects and lower associated risks compared to other estrogens. It is also studied for its potential benefits in urogynecological health, such as the treatment of menopausal symptoms like vaginal atrophy. Furthermore, its application is under investigation for autoimmune conditions such as multiple sclerosis, given its immunomodulatory properties. Ongoing research aims to delineate the therapeutic potential and safety profile of Estriol in various clinical contexts.

Formula: C₁₈H₂₄O₃

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 288.38 g/mol

Ref: 3D-FE22836