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CAS 50-27-1

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Estriol

Description:
Estriol, with the CAS number 50-27-1, is a naturally occurring estrogen and one of the three main estrogens produced by the human body, alongside estradiol and estrone. It is primarily synthesized in the placenta during pregnancy and plays a crucial role in maintaining pregnancy and fetal development. Estriol is characterized by its relatively weak estrogenic activity compared to estradiol and estrone, making it less potent in stimulating estrogen receptors. Chemically, it is a steroid hormone with a molecular formula of C18H24O3, featuring a phenolic structure that contributes to its biological activity. Estriol is often used in hormone replacement therapy, particularly for menopausal symptoms, and is also studied for its potential protective effects against certain hormone-related cancers. Its pharmacokinetics involve rapid metabolism and excretion, primarily through the liver. Due to its specific role in reproductive health, estriol levels are monitored during pregnancy and can be indicative of fetal well-being.
Formula:C18H24O3
InChI:InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
InChI key:InChIKey=PROQIPRRNZUXQM-ZXXIGWHRSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(C[C@@H](O)[C@@H]2O)[H]
Synonyms:
  • (16Alpha,17Beta)-Estra-1,3,5(10)-Triene-3,16,17-Triol
  • (16α,17β)-Estra-1,3,5(10)-triene-3,16,17-triol
  • (8R,13S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
  • 1,3,5 (10)-Estratriene-3, 16α, 17β-triol
  • 1,3,5(10)-Estratriene-3,16a,17b-triol
  • 13β-Methyl-1,3,5(10)-gonatriene-3,16α,17β-triol
  • 16α,17β-Estriol
  • 16α-Estriol
  • 16α-Hydroxyestradiol
  • 3,16α,17β-Estriol
  • See more synonyms
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