CAS 50-91-9: Floxuridine
Description:Floxuridine, with the CAS number 50-91-9, is a synthetic antimetabolite and a fluorinated pyrimidine analogue of uridine. It is primarily used in the treatment of certain types of cancer, particularly colorectal cancer and hepatic metastases. The compound functions by inhibiting DNA synthesis, thereby interfering with the proliferation of cancer cells. Floxuridine is typically administered via intravenous injection or intra-arterial infusion, allowing for targeted delivery to tumor sites. Its chemical structure includes a fluorine atom, which enhances its antitumor activity compared to its non-fluorinated counterparts. The substance is known for its potential side effects, which may include myelosuppression, gastrointestinal disturbances, and mucositis. Due to its potent effects and specific application in oncology, floxuridine is classified as a cytotoxic agent and is handled with care in clinical settings. As with many chemotherapeutic agents, monitoring for adverse reactions is essential during treatment.
Formula:C9H11FN2O5
InChI:InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI key:InChIKey=ODKNJVUHOIMIIZ-RRKCRQDMSA-N
SMILES:O=C1NC(=O)N(C=C1F)C2OC(CO)C(O)C2
- Synonyms:
- (+)-5-Fluorodeoxyuridine
- 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-5-fluorouracil
- 1-(2-Deoxy-β-D-ribofuranosyl)-5-fluorouracil
- 1-(2-deoxy-D-threo-pentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione
- 1-(2-deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione
- 2-Deoxy-5-fluorouridine
- 5-Fluoro-2'-deoxy-β-uridine
- 5-Fluoro-2?Deoxy Uridine
- 5-Fluorouracil 2'-deoxyriboside
- 5-Fluorouracil deoxyriboside
- See more synonyms
- 5-Fudr
- Deoxyfluorouridine
- FdUrd
- Floxiridina
- Floxuridin
- Floxuridine
- Fudr
- Nsc 26740
- Nsc 27640
- Uridine, 2'-deoxy-5-fluoro-
- 5-Fluoro-2′-deoxyuridine
- 5-Fluoro-2'-deoxyuridine
- 5-Fluoro-2-deoxyuridine
- (+)-5-Fluoro-2?deoxyuridine
