CAS 500-38-9

Nordihydroguaiaretic acid

Description:

Nordihydroguaiaretic acid (NDGA) is a naturally occurring phenolic compound primarily derived from the creosote bush (Larrea tridentata). It is characterized by its antioxidant properties, which are attributed to its ability to scavenge free radicals and inhibit lipid peroxidation. NDGA has a molecular formula of C15H14O4 and features a complex structure that includes two methoxy groups and a catechol moiety. This compound has been studied for its potential therapeutic applications, including anti-inflammatory and anticancer effects, although its use is limited due to potential toxicity and side effects. NDGA is also known to exhibit antimicrobial properties and has been investigated for its role in food preservation. In terms of solubility, it is moderately soluble in organic solvents but less so in water. Due to its unique chemical structure and biological activity, NDGA continues to be of interest in both pharmacological research and industrial applications. However, safety and regulatory considerations are essential when handling this compound.

Formula: C₁₈H₂₂O₄

InChI: InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3

InChI key: InChIKey=HCZKYJDFEPMADG-UHFFFAOYSA-N

SMILES: C(C(C(CC1=CC(O)=C(O)C=C1)C)C)C2=CC(O)=C(O)C=C2

Synonyms:

• 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane
• 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol)
• 4,4'-(2,3-Dimethyltetramethylen)dibrenzcatechin
• 4,4'-(2,3-Dimethyltetramethylene)Dipyrocatechol
• 4,4'-(2,3-Dimetiltetrametilen)Dipirocatecol
• 4,4′-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]
• 4-[4-(3,4-Dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
• Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl-
• Dihydronorguaiaretic acid
• Dinorguaiaretic acid, dihydro-
• Ndga
• Nordihydroguaiaretic acid
• Nordihydroguaiaretinsaeure
• Norguaiaretic acid, dihydro-
• Nsc 4291
• Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-
• β,γ-Dimethyl-α,δ-bis(3,4-dihydroxyphenyl)butane
• 1,2-Benzenediol, 4,4′-(2,3-dimethyl-1,4-butanediyl)bis-
• 4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]dibenzene-1,2-diol
• NDGA, Larrea divaricata

Nordihydroguaiaretic acid, 97%

CAS: 500-38-9

Nordihydroguaiaretic acid is used in the treatment of multiple diseases, including cardiovascular diseases, neurological disorders and cancers. It is also used as an antioxidant. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentatio

Formula: C₁₈H₂₂O₄

Purity: 97%

Color and Shape: Crystals or powder or crystalline powder, White to cream to pale brown to pale yellow

Molecular weight: 302.37

Ref: 02-L03149

Nordihydroguaiaretic acid

CAS: 500-38-9

Nordihydroguaiaretic acid analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₁₈H₂₂O₄

Purity: (HPLC) ≥95%

Color and Shape: Powder

Molecular weight: 302.38

Ref: 11-6135

Nordihydroguaiaretic acid

CAS: 500-38-9

Formula: C₁₈H₂₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 302.3649

Ref: IN-DA003TAG

Nordihydroguaiaretic Acid

CAS: 500-38-9

Nordihydroguaiaretic Acid

Purity: 95%

Molecular weight: 302.36g/mol

Ref: 54-OR1023910

Nordihydroguaiaretic acid

CAS: 500-38-9

Nordihydroguaiaretic acid

Purity: ≥80%

Molecular weight: 302.36g/mol

Ref: 54-BUP14743

Nordihydroguaiaretic acid

CAS: 500-38-9

Formula: C₁₈H₂₂O₄

Purity: ≥ 97.0%

Color and Shape: White to off-white or faint yellow-beige powder or crystals

Molecular weight: 302.37

Ref: 7W-GE5483

Nordihydroguaiaretic Acid

CAS: 500-38-9

Formula: C₁₈H₂₂O₄

Purity: >97.0%(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 302.37

Ref: 3B-D0800

GB 5009.32-2016 Antioxidants Mixture 161 1000 mg/L in Acetonitrile

Controlled Product

CAS: 1034-01-1, 1166-52-5, 121-79-9, 128-37-0, 1421-63-2, 1948-33-0, 25013-16-5, 500-38-9, 88-26-6

Color and Shape: Mixture

Ref: 04-A50000161AL

Nordihydroguaiaretic Acid

CAS: 500-38-9

Formula: C₁₈H₂₂O₄

Color and Shape: Neat

Molecular weight: 302.36

Ref: 04-C15644200

Nordihydroguaiaretic acid

CAS: 500-38-9

Nordihydroguaiaretic acid (NDGA) is a natural lipoxygenase (5-LOX) inhibitor. Nordihydroguaiaretic acid has antioxidant effect. Cost-effective and quality-assured.

Formula: C₁₈H₂₂O₄

Purity: 97.82% - 99.91%

Color and Shape: Solid

Molecular weight: 302.36

Ref: TM-TJS2190

Nordihydroguaiaretic acid

CAS: 500-38-9

Polyphenol

Formula: C₁₈H₂₂O₄

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 302.37

Ref: 5G-82880

Nordihydro Guaiaretic Acid (mixture of diastereomers)

Controlled Product

CAS: 500-38-9

Applications Nordihydro Guaiaretic Acid is a lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure. Inhibitor of broad bean lipoxygenase. The oxidation product from Resveratrol (R150000) showed a high inhibitory activity, whereas Resveratrol itself had no activity and its oxidation efficiency was low.
References Brash, A., et al.: J. Biol. Chem., 274, 23679 (1999), Fujimoto, A., et al.: Bioorg. Med. Chem. Lett., 20, 7393 (2010), Ridolfi, M., et al.: J. Agric. Food Chem., 50, 835 (2002),

Formula: C₁₈H₂₂O₄

Color and Shape: White To Brown

Molecular weight: 302.36

Ref: TR-N673000

Nordihydroguaiaretic acid - mixture of diastereomers

CAS: 500-38-9

Nordihydroguaiaretic acid - mixture of diastereomers is a potent antioxidant compound, regarded as a lignan. This compound is primarily sourced from the creosote bush, known scientifically as *Larrea tridentata*. The mode of action of nordihydroguaiaretic acid involves its ability to scavenge free radicals, effectively neutralizing them and thus protecting cellular components from oxidative damage.

Formula: C₁₈H₂₂O₄

Color and Shape: Powder

Molecular weight: 302.36 g/mol

Ref: 3D-FN26437

Nordihydroguaiaretic acid

CAS: 500-38-9

Nordihydroguaiaretic acid is a lignan-type compound, which is a naturally occurring product primarily sourced from the resin of the creosote bush, *Larrea tridentata*. It functions as a powerful antioxidant through the inhibition of lipid peroxidation and scavenging of free radicals, thereby preventing oxidative stress in biological systems.

Formula: C₁₈H₂₂O₄

Molecular weight: 302.37 g/mol

Ref: 3D-N-8500