CAS 500-38-9
:Nordihydroguaiaretic acid
Description:
Nordihydroguaiaretic acid (NDGA) is a naturally occurring phenolic compound primarily derived from the creosote bush (Larrea tridentata). It is characterized by its antioxidant properties, which are attributed to its ability to scavenge free radicals and inhibit lipid peroxidation. NDGA has a molecular formula of C15H14O4 and features a complex structure that includes two methoxy groups and a catechol moiety. This compound has been studied for its potential therapeutic applications, including anti-inflammatory and anticancer effects, although its use is limited due to potential toxicity and side effects. NDGA is also known to exhibit antimicrobial properties and has been investigated for its role in food preservation. In terms of solubility, it is moderately soluble in organic solvents but less so in water. Due to its unique chemical structure and biological activity, NDGA continues to be of interest in both pharmacological research and industrial applications. However, safety and regulatory considerations are essential when handling this compound.
Formula:C18H22O4
InChI:InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
InChI key:InChIKey=HCZKYJDFEPMADG-UHFFFAOYSA-N
SMILES:C(C(C(CC1=CC(O)=C(O)C=C1)C)C)C2=CC(O)=C(O)C=C2
Synonyms:- 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane
- 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol)
- 4,4'-(2,3-Dimethyltetramethylen)dibrenzcatechin
- 4,4'-(2,3-Dimethyltetramethylene)Dipyrocatechol
- 4,4'-(2,3-Dimetiltetrametilen)Dipirocatecol
- 4,4′-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]
- 4-[4-(3,4-Dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
- Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl-
- Dihydronorguaiaretic acid
- Dinorguaiaretic acid, dihydro-
- Ndga
- Nordihydroguaiaretic acid
- Nordihydroguaiaretinsaeure
- Norguaiaretic acid, dihydro-
- Nsc 4291
- Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-
- β,γ-Dimethyl-α,δ-bis(3,4-dihydroxyphenyl)butane
- 1,2-Benzenediol, 4,4′-(2,3-dimethyl-1,4-butanediyl)bis-
- 4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]dibenzene-1,2-diol
- NDGA, Larrea divaricata
- See more synonyms
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Nordihydroguaiaretic Acid
CAS:Formula:C18H22O4Purity:>97.0%(HPLC)Color and Shape:White to Orange to Green powder to crystalMolecular weight:302.37Nordihydroguaiaretic acid, 97%
CAS:Nordihydroguaiaretic acid is used in the treatment of multiple diseases, including cardiovascular diseases, neurological disorders and cancers. It is also used as an antioxidant. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentatioFormula:C18H22O4Purity:97%Color and Shape:Crystals or powder or crystalline powder, White to cream to pale brown to pale yellowMolecular weight:302.37Nordihydroguaiaretic acid
CAS:Nordihydroguaiaretic acidFormula:C18H22O4Purity:99.5%Molecular weight:302.36Nordihydroguaiaretic Acid
CAS:Nordihydroguaiaretic AcidFormula:C18H22O4Purity:>95%Molecular weight:302.36Nordihydroguaiaretic acid
CAS:Formula:C18H22O4Purity:≥ 97.0%Color and Shape:White to off-white or faint yellow-beige powder or crystalsMolecular weight:302.37GB 5009.32-2016 Antioxidants Mixture 161 1000 mg/L in Acetonitrile
CAS:Controlled ProductColor and Shape:MixtureNordihydroguaiaretic acid
CAS:Nordihydroguaiaretic acid analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.Formula:C18H22O4Purity:(HPLC) ≥95%Color and Shape:PowderMolecular weight:302.38Nordihydroguaiaretic acid
CAS:Formula:C18H22O4Purity:98%Color and Shape:SolidMolecular weight:302.3649Nordihydro Guaiaretic Acid (mixture of diastereomers)
CAS:Controlled ProductApplications Nordihydro Guaiaretic Acid is a lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure. Inhibitor of broad bean lipoxygenase. The oxidation product from Resveratrol (R150000) showed a high inhibitory activity, whereas Resveratrol itself had no activity and its oxidation efficiency was low.
References Brash, A., et al.: J. Biol. Chem., 274, 23679 (1999), Fujimoto, A., et al.: Bioorg. Med. Chem. Lett., 20, 7393 (2010), Ridolfi, M., et al.: J. Agric. Food Chem., 50, 835 (2002),Formula:C18H22O4Color and Shape:NeatMolecular weight:302.36Nordihydroguaiaretic acid
CAS:Nordihydroguaiaretic acid (NDGA) is a natural lipoxygenase (5-LOX) inhibitor. Nordihydroguaiaretic acid has antioxidant effect. Cost-effective and quality-assured.Formula:C18H22O4Purity:97.82% - 99.91%Color and Shape:Brown SolidMolecular weight:302.3649Nordihydroguaiaretic acid
CAS:PolyphenolFormula:C18H22O4Purity:≥ 98.0 % (HPLC)Color and Shape:PowderMolecular weight:302.37Nordihydroguaiaretic acid - mixture of diastereomers
CAS:Nordihydroguaiaretic acid - mixture of diastereomers is a potent antioxidant compound, regarded as a lignan. This compound is primarily sourced from the creosote bush, known scientifically as *Larrea tridentata*. The mode of action of nordihydroguaiaretic acid involves its ability to scavenge free radicals, effectively neutralizing them and thus protecting cellular components from oxidative damage.Formula:C18H22O4Color and Shape:PowderMolecular weight:302.36 g/molNordihydroguaiaretic acid (NDGA) in Acetonitrile
CAS:AcetonitrileFormula:C18H22O4Molecular weight:302.4Nordihydroguaiaretic acid
CAS:4,4'-(2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol)Formula:C18H22O4Purity:98%Molecular weight:302.36
