CAS 50679-08-8

Terfenadine

Description:

Terfenadine is an antihistamine that was primarily used to treat allergic conditions such as hay fever and hives. It belongs to the class of second-generation antihistamines, which are designed to minimize sedation compared to first-generation antihistamines. Terfenadine is a selective antagonist of the H1 histamine receptor, effectively blocking the action of histamine, a compound involved in allergic responses. The substance is characterized by its relatively low solubility in water and its lipophilic nature, which allows it to cross cell membranes easily. However, terfenadine has been associated with serious cardiac side effects, particularly when taken in conjunction with certain other medications that inhibit its metabolism, leading to potentially life-threatening arrhythmias. Due to these safety concerns, terfenadine was withdrawn from the market in many countries. Its chemical structure includes a triphenylmethanol moiety, contributing to its pharmacological properties. As a result, terfenadine is no longer widely used, and safer alternatives have since been developed for allergy treatment.

Formula: C₃₂H₄₁NO₂

InChI: InChI=1S/C32H41NO2/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29-30,34-35H,10,15,20-24H2,1-3H3

InChI key: InChIKey=GUGOEEXESWIERI-UHFFFAOYSA-N

SMILES: C(O)(C1CCN(CCCC(O)C2=CC=C(C(C)(C)C)C=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4

Synonyms:

• 1,2-Dipalmitoyl-sn-glycero-3-phospho-L-serine, sodium salt
• 1-(4-Tert-Butylphenyl)-4-(4-(Hydroxydiphenylmethyl)Piperid-1-Yl)Butan-1-Ol
• 1-(4-Tert-Butylphenyl)-4-{4-[Hydroxy(Diphenyl)Methyl]Piperidin-1-Yl}Butan-1-Ol
• 1-Piperidinebutanol, α-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-
• 1-[(4R)-4-(4-tert-butylphenyl)-4-hydroxybutyl]-4-[hydroxy(diphenyl)methyl]piperidinium
• 1-[(4S)-4-(4-tert-butylphenyl)-4-hydroxybutyl]-4-[hydroxy(diphenyl)methyl]piperidinium
• Allerplus
• Cyater
• DPPS, Na
• Histadin
• Histafen
• Mdl 9918
• Nebralin
• Nsc 665802
• Racemic terfenadine
• Seldane
• Teldane
• Teldanex
• Terdin
• Terfenadin
• Terfenadina
• Terfenadine (Patent No Supply)
• Terfex
• Terfinax
• Ternadin
• Triludan
• dl-Terfenadine
• α-(p-tert-Butylphenyl)-4-(α-hydroxy-α-phenylbenzyl)-1-piperidinebutanol
• α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol

Terfenadine

CAS: 50679-08-8

Formula: C₃₂H₄₁NO₂

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 471.69

Ref: 3B-T3977

Terfenadine

CAS: 50679-08-8

Color and Shape: Neat

Ref: 61-FOR0055.00

TERFENADINE CRS

CAS: 50679-08-8

TERFENADINE CRS

Formula: C₃₂H₄₁NO₂

Molecular weight: 471.6734

Ref: 41-T0071000

Terfenadine

CAS: 50679-08-8

Terfenadine

Formula: C₃₂H₄₁NO₂

Purity: 99.8%

Color and Shape: White To Off-White

Molecular weight: 471.31373

Ref: 47-650

Terfenadine

CAS: 50679-08-8

Formula: C₃₂H₄₁NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 471.6734

Ref: IN-DA003UIK

Terfenadine

CAS: 50679-08-8

Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.

Formula: C₃₂H₄₁NO₂

Purity: 98.76% - 99.75%

Color and Shape: Solid

Molecular weight: 471.67

Ref: TM-T1266

Terfenadine

CAS: 50679-08-8

Terfenadine

Purity: 98%

Molecular weight: 471.67g/mol

Ref: 54-OR1027822

Terfenadine

CAS: 50679-08-8

Formula: C₃₂H₄₁NO₂

Molecular weight: 471.69

Ref: 4Z-T-195001

Terfenadine

CAS: 50679-08-8

Terfenadine

Purity: ≥98%

Molecular weight: 471.67g/mol

Ref: 54-BUP14692

Terfenadine

CAS: 50679-08-8

Formula: C₃₂H₄₁NO₂

Color and Shape: Neat

Molecular weight: 471.67

Ref: 04-C17322080

Terfenadine

Controlled Product

CAS: 50679-08-8

Formula: C₃₂H₄₁NO₂

Color and Shape: Neat

Molecular weight: 471.67

Ref: 86-MM0055.00

Terfenadine

CAS: 50679-08-8

Formula: C₃₂H₄₁NO₂

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 471.67

Ref: 7W-GP2305

Terfenadine

Controlled Product

CAS: 50679-08-8

Applications Nonsedating-type histamine H1-receptor antagonist. Antihistaminic.
References Carr, A.A., et al.: Arzneim. Forsch., 32, 1157 (1982), Badwan, A.A., et al.: Anal. Profiles Drug Subs., 19, 627 (1990), Masheter, H.C., et al.: Clin. Rev. Allergy, 11, 5 (1993), Jurima-Romet, M., et al.: Drug Metab. Dispos., 22, 849 (1994),

Formula: C₃₂H₄₁NO₂

Color and Shape: White To Off-White

Molecular weight: 471.67

Ref: TR-T114500

Terfenadine - Bio-X ™

Controlled Product

CAS: 50679-08-8

Terfenadine is an antihistamine drug that is used for the treatment of allergy symptoms such as edema and flare ups. This drug is a histamine receptor antagonist and competes with histamine for binding with the H1 receptor. It occurs at sites such as the GI tract, uterus and blood vessels.

Formula: C₃₂H₄₁NO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 471.67 g/mol

Ref: 3D-BT166253

Terfenadine

Controlled Product

CAS: 50679-08-8

Histamine (H1) receptor antagonist; blocks hERG and Kir6 channels

Formula: C₃₂H₄₁NO₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 471.67 g/mol

Ref: 3D-FD28043

Terfenadine-d10

Controlled Product

CAS: 50679-08-8

Formula: C₃₂D₁₀H₃₁NO₂

Color and Shape: Neat

Molecular weight: 481.735

Ref: TR-T114503