CAS 50679-08-8
:Terfenadine
Description:
Terfenadine is an antihistamine that was primarily used to treat allergic conditions such as hay fever and hives. It belongs to the class of second-generation antihistamines, which are designed to minimize sedation compared to first-generation antihistamines. Terfenadine is a selective antagonist of the H1 histamine receptor, effectively blocking the action of histamine, a compound involved in allergic responses. The substance is characterized by its relatively low solubility in water and its lipophilic nature, which allows it to cross cell membranes easily. However, terfenadine has been associated with serious cardiac side effects, particularly when taken in conjunction with certain other medications that inhibit its metabolism, leading to potentially life-threatening arrhythmias. Due to these safety concerns, terfenadine was withdrawn from the market in many countries. Its chemical structure includes a triphenylmethanol moiety, contributing to its pharmacological properties. As a result, terfenadine is no longer widely used, and safer alternatives have since been developed for allergy treatment.
Formula:C32H41NO2
InChI:InChI=1S/C32H41NO2/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29-30,34-35H,10,15,20-24H2,1-3H3
InChI key:InChIKey=GUGOEEXESWIERI-UHFFFAOYSA-N
SMILES:C(O)(C1CCN(CCCC(O)C2=CC=C(C(C)(C)C)C=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4
Synonyms:- 1,2-Dipalmitoyl-sn-glycero-3-phospho-L-serine, sodium salt
- 1-(4-Tert-Butylphenyl)-4-(4-(Hydroxydiphenylmethyl)Piperid-1-Yl)Butan-1-Ol
- 1-(4-Tert-Butylphenyl)-4-{4-[Hydroxy(Diphenyl)Methyl]Piperidin-1-Yl}Butan-1-Ol
- 1-Piperidinebutanol, α-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-
- 1-[(4R)-4-(4-tert-butylphenyl)-4-hydroxybutyl]-4-[hydroxy(diphenyl)methyl]piperidinium
- 1-[(4S)-4-(4-tert-butylphenyl)-4-hydroxybutyl]-4-[hydroxy(diphenyl)methyl]piperidinium
- Allerplus
- Cyater
- DPPS, Na
- Histadin
- Histafen
- Mdl 9918
- Nebralin
- Nsc 665802
- Racemic terfenadine
- Seldane
- Teldane
- Teldanex
- Terdin
- Terfenadin
- Terfenadina
- Terfenadine (Patent No Supply)
- Terfex
- Terfinax
- Ternadin
- Triludan
- dl-Terfenadine
- α-(p-tert-Butylphenyl)-4-(α-hydroxy-α-phenylbenzyl)-1-piperidinebutanol
- α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol
- See more synonyms
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Terfenadine
CAS:Formula:C32H41NO2Purity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:471.69Terfenadine
CAS:TerfenadineFormula:C32H41NO2Purity:99.8%Color and Shape:White To Off-WhiteMolecular weight:471.31373Terfenadine
CAS:Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.Formula:C32H41NO2Purity:98.76% - 99.97%Color and Shape:SolidMolecular weight:471.671-(4-(tert-Butyl)phenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol
CAS:Formula:C32H41NO2Purity:98%Color and Shape:SolidMolecular weight:471.6734Terfenadine (Standard)
CAS:Terfenadine (Standard) is the standard substance of Terfenadine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects.Formula:C32H41NO2Color and Shape:SolidMolecular weight:471.67Terfenadine
CAS:Controlled ProductApplications Nonsedating-type histamine H1-receptor antagonist. Antihistaminic.
References Carr, A.A., et al.: Arzneim. Forsch., 32, 1157 (1982), Badwan, A.A., et al.: Anal. Profiles Drug Subs., 19, 627 (1990), Masheter, H.C., et al.: Clin. Rev. Allergy, 11, 5 (1993), Jurima-Romet, M., et al.: Drug Metab. Dispos., 22, 849 (1994),Formula:C32H41NO2Color and Shape:NeatMolecular weight:471.671-(4-(tert-Butyl)phenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol
CAS:Formula:C32H41NO2Purity:98%Molecular weight:471.67Terfenadine
CAS:Formula:C32H41NO2Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:471.67Terfenadine - Bio-X ™
CAS:Controlled ProductTerfenadine is an antihistamine drug that is used for the treatment of allergy symptoms such as edema and flare ups. This drug is a histamine receptor antagonist and competes with histamine for binding with the H1 receptor. It occurs at sites such as the GI tract, uterus and blood vessels.Formula:C32H41NO2Purity:Min. 95%Color and Shape:PowderMolecular weight:471.67 g/molTerfenadine
CAS:Controlled ProductHistamine (H1) receptor antagonist; blocks hERG and Kir6 channels
Formula:C32H41NO2Purity:Min. 95%Color and Shape:White PowderMolecular weight:471.67 g/mol
