CAS 507475-17-4

2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide

Description:

2-(Carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide, with the CAS number 507475-17-4, is a chemical compound characterized by its thiophene core, which is a five-membered heterocyclic ring containing sulfur. This compound features a carbamoylamino group and a carboxamide functional group, contributing to its potential as a bioactive molecule. The presence of a 4-fluorophenyl substituent enhances its lipophilicity and may influence its biological activity. The thiophene structure is known for its stability and ability to participate in various chemical reactions, making it a versatile scaffold in medicinal chemistry. This compound may exhibit properties such as anti-inflammatory or anticancer activities, although specific biological data would depend on empirical studies. Its solubility, melting point, and reactivity would be influenced by the functional groups present, which can also affect its pharmacokinetic properties. Overall, this compound represents a class of thiophene derivatives that are of interest in pharmaceutical research and development.

Formula: C₁₂H₁₀FN₃O₂S

InChI: InChI=1/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)

SMILES: c1cc(ccc1c1cc(C(=N)O)c(NC(=N)O)s1)F

Synonyms:

• 2-((Aminocarbonyl)Amino)-5-(4-Fluorophenyl)-3-Thiophenecarboxamide
• 3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-

TPCA-1

CAS: 507475-17-4

TPCA-1

Purity: ≥95%

Molecular weight: 279.29g/mol

Ref: 54-BUP02172

TPCA-1

CAS: 507475-17-4

Formula: C₁₂H₁₀FN₃O₂S

Molecular weight: 279.29

Ref: 7W-GL3397

TPCA-1

CAS: 507475-17-4

TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases

Formula: C₁₂H₁₀FN₃O₂S

Purity: 95.03% - 97.86%

Color and Shape: Solid

Molecular weight: 279.29

Ref: TM-T3049

TPCA-1

CAS: 507475-17-4

Applications TPCA-1 is a direct dual inhibitor for both IKKβ (IKK-2) and STAT3. It inhibits STAT3 phosphorylation, DNA binding, and transactivation in vivo. Synergistic treatment of TPCA-1 with tyrosine kinase inhibitors (TKIs) can potentially be a more effective method for treating cancers.
References Nan, J., et al.: Mol. Cancer Ther., 13, 617 (2014); Birrell, M.A., et al.: Am. J. Respir. Crit. Care Med., 172, 962 (2005); Birrell, M.A., et al.: Mol. Pharmacol., 69, 1791 (2006)

Formula: C₁₂H₁₀FN₃O₂S

Color and Shape: Light Beige Solid

Molecular weight: 279.2901

Ref: TR-T700500

TPCA-1

CAS: 507475-17-4

Inhibitor of NFκB and STAT3 transcription factor

Formula: C₁₂H₁₀FN₃O₂S

Purity: Min. 95%

Molecular weight: 279.29 g/mol

Ref: 3D-FT100211