CAS 50773-41-6

Polyphyllin A

Description:

Polyphyllin A is a natural steroidal saponin primarily derived from the plant species Paris polyphylla, which is known for its traditional medicinal uses. This compound is characterized by its complex glycosidic structure, which includes a steroid backbone linked to multiple sugar moieties. Polyphyllin A exhibits a range of biological activities, including anti-inflammatory, anticancer, and antimicrobial properties, making it a subject of interest in pharmacological research. Its mechanism of action often involves the induction of apoptosis in cancer cells and modulation of various signaling pathways. Additionally, Polyphyllin A is known for its potential to enhance the bioavailability of other therapeutic agents. However, its use is accompanied by considerations regarding toxicity and side effects, necessitating further studies to fully understand its safety profile and therapeutic potential. Overall, Polyphyllin A represents a significant compound in the field of natural products and medicinal chemistry, highlighting the importance of plant-derived substances in drug discovery.

Formula: C₄₄H₇₀O₁₆

Synonyms:

• Paris saponin Pa
• Polyphillin D
• Polyphyllin D
• Polyphyllin I
• Chonglou Saponin I

Polyphyllin D

CAS: 50773-41-6

Formula: C₄₄H₇₀O₁₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 855.0170

Ref: IN-DA00DA54

Polyphyllin I

CAS: 50773-41-6

Formula: C₄₄H₇₀O₁₆

Molecular weight: 855.03

Ref: 7W-GY0490

Polyphyllin I

CAS: 50773-41-6

Polyphyllin I

Purity: ≥98%

Molecular weight: 855.02g/mol

Ref: 54-BUP06481

Polyphyllin I

CAS: 50773-41-6

Polyphyllin D has anti-angiogenic, and anticancer effects, it induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C and cleaved-caspase-3 levels.Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis.

Formula: C₄₄H₇₀O₁₆

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 855.028

Ref: BP-BP3323

Polyphyllin I

CAS: 50773-41-6

Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,

Formula: C₄₄H₇₀O₁₆

Purity: 98% - 99.5%

Color and Shape: Solid

Molecular weight: 855.02

Ref: TM-T3895

Polyphyllin d

CAS: 50773-41-6

Natural glycoside

Formula: C₄₄H₇₀O₁₆

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 855.02

Ref: 5G-80560

Polyphyllin D

CAS: 50773-41-6

Polyphyllin D is a natural compound, which is a steroidal saponin extracted from the rhizome of Paris polyphylla, a traditional Chinese medicinal plant. It exhibits significant biological activities and has garnered interest for its potential therapeutic applications. Polyphyllin D exerts its effects primarily through the disruption of cellular processes, including the induction of apoptosis, modulation of the cell cycle, and inhibition of angiogenesis. It achieves these actions by influencing multiple molecular pathways, such as the mitochondrial apoptotic pathway and autophagy regulation.

Formula: C₄₄H₇₀O₁₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 855.02 g/mol

Ref: 3D-OP42701

Polyphyllin I

Controlled Product

CAS: 50773-41-6

Applications Polyphylin II is a natural saponin extracted from the plant, Paris polyphylla, and displays antiproliferative activity in vivo. Used in the treatment of lung and cervical cancers.
References Ma, D. et al.: J. Int Med. Res., 37, 631 (2009); Yin, X. et al.: Biomed. Chrom., 27, 343 (2013); Jiang, H. et al.: Mol. Med. Rep., 9, 2265 (2014);

Formula: C₂₇H₂₉F₃O₆S

Color and Shape: Neat

Molecular weight: 538.576

Ref: TR-P689455