CAS 50847-11-5

Ibudilast

Description:

Ibudilast, with the CAS number 50847-11-5, is a small organic molecule primarily recognized for its anti-inflammatory and neuroprotective properties. It is classified as a phosphodiesterase inhibitor, which means it can enhance the levels of cyclic nucleotides, such as cAMP and cGMP, within cells, leading to various physiological effects. Ibudilast is known to modulate the immune response and has been investigated for its potential therapeutic applications in conditions like multiple sclerosis, neuropathic pain, and asthma. The compound is typically administered orally and exhibits good bioavailability. Its mechanism of action involves not only the inhibition of phosphodiesterase but also the modulation of pro-inflammatory cytokines, making it a candidate for treating chronic inflammatory diseases. Additionally, Ibudilast has shown promise in preclinical studies for neurodegenerative disorders, highlighting its potential role in protecting neuronal cells from damage. Overall, its multifaceted effects on the immune system and nervous system make it a compound of interest in pharmacological research.

Formula: C₁₄H₁₈N₂O

InChI: InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3

InChI key: InChIKey=ZJVFLBOZORBYFE-UHFFFAOYSA-N

SMILES: C(C(C)C)(=O)C1=C2N(N=C1C(C)C)C=CC=C2

Synonyms:

• 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one
• 1-Propanone, 2-methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-
• 2-Isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine
• 2-Methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
• 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone
• 2-Methyl-1-[2-(Propan-2-Yl)Pyrazolo[1,5-A]Pyridin-3-Yl]Propan-1-One
• 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine
• Av 411
• Kc 404
• Ketas
• Pinatos

Ibudilast

CAS: 50847-11-5

Formula: C₁₄H₁₈N₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 230.31

Ref: 3B-I0740

1-Propanone, 2-methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-

CAS: 50847-11-5

Formula: C₁₄H₁₈N₂O

Purity: 99%

Color and Shape: Solid

Molecular weight: 230.3055

Ref: IN-DA00I944

3-Isobutyryl-2-Isopropylpyrazolo[1,5-a]Pyridine

CAS: 50847-11-5

3-Isobutyryl-2-Isopropylpyrazolo[1,5-a]Pyridine

Purity: 99%

Molecular weight: 230.31g/mol

Ref: 54-OR1011020

Ibudilast

CAS: 50847-11-5

Formula: C₁₄H₁₈N₂O

Color and Shape: White To Off-White Solid

Molecular weight: 230.31

Ref: 4Z-I-311

Ibudilast-d7

CAS: 50847-11-5

Formula: C₁₄H₁₁D₇N₂O

Color and Shape: White To Off-White Solid

Molecular weight: 237.35

Ref: 4Z-I-312

Ibudilast

CAS: 50847-11-5

Ibudilast

Purity: ≥98%

Molecular weight: 230.31g/mol

Ref: 54-BUP15098

Ibudilast

CAS: 50847-11-5

Formula: C₁₄H₁₈N₂O

Purity: ≥ 99.0%

Color and Shape: White powder

Molecular weight: 230.31

Ref: 7W-GP7898

Ibudilast

CAS: 50847-11-5

Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.

Formula: C₁₄H₁₈N₂O

Purity: 99.83% - >99.99%

Color and Shape: White Solid

Molecular weight: 230.31

Ref: TM-T2137

Ibudilast-d7

Controlled Product

CAS: 50847-11-5

Applications Ibudilast-d7 is the labeled analogue of Ibudilast (I125000), a leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral).
References Nishino, K., et al.: Japan J. Pharmacol., 33, 267 (1983); Ohashi, M., et al.: Arch. Int. Pharmacodyn., 280, 216 (1986); Armstead, W.M., et al.: J. Pharmacol., Exp. Ther., 244, 138 (1988)

Formula: C₁₄H₁₁D₇N₂O

Color and Shape: Neat

Molecular weight: 237.35

Ref: TR-I125003

Ibudilast

CAS: 50847-11-5

Phosphodiesterase PDE4 inhibitor

Formula: C₁₄H₁₈N₂O

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 230.14191

Ref: 3D-FI24525

1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one

CAS: 50847-11-5

Formula: C₁₄H₁₈N₂O

Purity: 99%

Color and Shape: Solid, White to very pale yellow powder

Molecular weight: 230.311

Ref: 10-F069148

Ibudilast

Controlled Product

CAS: 50847-11-5

Applications A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral). PDE inhibitor (non-selective).
References Nishino, K., et al.: Japan J. Pharmacol., 33, 267 (1983), Ohashi, M., et al.: Arch. Int. Pharmacodyn., 280, 216 (1986), Armstead, W.M., et al.: J. Pharmacol., Exp. Ther., 244, 138 (1988),

Formula: C₁₄H₁₈N₂O

Color and Shape: Neat

Molecular weight: 230.31

Ref: TR-I125000