CAS 509-20-6

Aconine

Description:

Aconine, with the CAS number 509-20-6, is an alkaloid derived from the plant Aconitum, commonly known as monkshood or wolfsbane. It is characterized by its potent pharmacological properties, particularly its neurotoxic effects. Aconine is known to interact with voltage-gated sodium channels, leading to disruptions in nerve signal transmission, which can result in symptoms such as muscle paralysis and cardiovascular disturbances. The compound is typically found in the roots and leaves of Aconitum species, and its structure features a complex bicyclic framework typical of many alkaloids. Due to its toxicity, aconine has limited therapeutic applications and is primarily of interest in toxicology and pharmacology research. Handling aconine requires caution, as it can be lethal in relatively small doses. Its presence in herbal remedies and traditional medicine underscores the importance of understanding its effects and potential risks. Overall, aconine exemplifies the dual nature of many natural compounds, possessing both significant biological activity and potential hazards.

Formula: C₂₅H₄₁NO₉

InChI: InChI=1/C25H41NO9/c1-6-26-9-22(10-32-2)12(27)7-13(33-3)24-11-8-23(30)19(28)14(11)25(31,20(29)21(23)35-5)15(18(24)26)16(34-4)17(22)24/h11-21,27-31H,6-10H2,1-5H3/t11-,12?,13?,14-,15?,16?,17-,18-,19?,20?,21?,22?,23-,24?,25-/m1/s1

InChI key: InChIKey=SQMGCPHFHQGPIF-UUKFDUHUSA-N

SMILES: O(C)[C@@H]1[C@@]23[C@]4([C@](COC)(CN(CC)[C@@]2([C@]([C@@H]4OC)([C@]5(O)[C@@]6([C@]3(C[C@@](O)([C@@H]6O)[C@@H](OC)[C@@H]5O)[H])[H])[H])[H])[C@H](O)C1)[H]

Synonyms:

• (1a,3a,6a,14a,15a,16b)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol
• (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol
• 11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-3,8,13,14,15-pentol deriv.
• Aconine
• Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, (1α,3α,6α,14α,15α,16β)-
• Aconitysat
• Jesaconine
• 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13...
• Aconine (Jesaconine)
• ACONINE USP/EP/BP
• 20-Ethyl-1α,6α,16β-trimethoxy-4-(methoxymethyl)aconitane-3α,8,13,14α,15α-pentol
• (15S,16S)-20-Ethyl-1α,6α,16-trimethoxy-4-(methoxymethyl)aconitane-3α,8β,13β,14α,15-pentol

Aconine

CAS: 509-20-6

Formula: C₂₅H₄₁NO₉

Purity: 99%

Color and Shape: Solid

Molecular weight: 499.5943

Ref: IN-DA00DB81

Aconine

CAS: 509-20-6

Aconine

Purity: ≥98%

Molecular weight: 499.59g/mol

Ref: 54-BUP08690

Aconine

CAS: 509-20-6

Formula: C₂₅H₄₁NO₉

Molecular weight: 499.60

Ref: 7W-GY9846

Aconine

CAS: 509-20-6

Aconine can inhibit RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression.

Formula: C₂₅H₄₁NO₉

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 499.601

Ref: BP-BP0120

Aconine

CAS: 509-20-6

1. Aconine (Jesaconine) is the febrifuge. 2. Aconine possesses gastric anaesthetic props.

Formula: C₂₅H₄₁NO₉

Purity: 99.61% - 99.93%

Color and Shape: Solid

Molecular weight: 499.59

Ref: TM-T4S1881

Aconine

CAS: 509-20-6

Natural alkaloid

Formula: C₂₅H₄₁NO₉

Purity: ≥ 90.0 % (HPLC)

Molecular weight: 499.59

Ref: 5G-82295

Aconine

Controlled Product

CAS: 509-20-6

Formula: C₂₅H₄₁NO₉

Color and Shape: Neat

Molecular weight: 499.59

Ref: TR-A190245