CAS 50924-49-7

Mizoribine

Description:

Mizoribine, with the CAS number 50924-49-7, is an immunosuppressive agent primarily used in the treatment of autoimmune diseases and organ transplantation. It is a purine analog that inhibits the synthesis of nucleotides, thereby affecting lymphocyte proliferation and function. Mizoribine is characterized by its ability to selectively suppress T and B cell activity, making it valuable in preventing graft rejection and managing conditions like rheumatoid arthritis. The compound is typically administered orally and is known for its relatively favorable side effect profile compared to other immunosuppressants. Its mechanism of action involves the inhibition of inosine monophosphate dehydrogenase, which is crucial for the de novo synthesis of purines. Mizoribine is also noted for its pharmacokinetic properties, including its metabolism and excretion, which can vary among individuals. Overall, Mizoribine represents an important therapeutic option in the field of immunology and transplant medicine, contributing to improved patient outcomes in various clinical settings.

Formula: C₉H₁₃N₃O₆

InChI: InChI=1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1

InChI key: InChIKey=HZQDCMWJEBCWBR-UUOKFMHZSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(O)=C(C(N)=O)N=C2

Synonyms:

• 1H-Imidazole-4-carboxamide, 5-hydroxy-1-beta-D-ribofuranosyl-
• 1H-Imidazole-4-carboxamide, 5-hydroxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 4-Carbamoyl-1-beta-D-ribofuranosyl-imidazolium-5-olate
• 5-Hydroxy-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide
• 5-Hydroxy-1-beta-D-ribofuranosylimidazole-4-carboxamide
• 5-Hydroxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-imidazole-4-carboxamide
• 5-hydroxy-1-pentofuranosyl-1H-imidazole-4-carboxamide
• Anhydro-4-carbamoyl-5-hydroxy-1-beta-D-ribofuranosyl-imidazolium hydroxide
• Bredinin
• Bredinine
• Brn 4151713
• He-69
• MZR
• Mizoribina
• Mizoribina [INN-Spanish]
• Mizoribinum
• NSC 289637
• Unii-4Jr41A10Vp
• β-Bredinin
• 1H-Imidazole-4-carboxamide, 5-hydroxy-1-β-D-ribofuranosyl-
• Mizoribine

Mizoribine

CAS: 50924-49-7

Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.

Formula: C₉H₁₃N₃O₆

Purity: 98.38% - 99.95%

Color and Shape: White To Off-White Crystalline Powder

Molecular weight: 259.22

Ref: TM-T1188

1H-Imidazole-4-carboxamide, 5-hydroxy-1-b-D-ribofuranosyl-

CAS: 50924-49-7

Formula: C₉H₁₃N₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 259.2160

Ref: IN-DA00I94P

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-5-Hydroxy-1H-Imidazole-4-Carboxamide

CAS: 50924-49-7

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-5-Hydroxy-1H-Imidazole-4-Carboxamide

Purity: 98%

Molecular weight: 259.22g/mol

Ref: 54-OR1026407

Mizoribine

CAS: 50924-49-7

Mizoribine

Purity: ≥98%

Molecular weight: 259.22g/mol

Ref: 54-BUP13728

Mizoribine

CAS: 50924-49-7

Formula: C₉H₁₃N₃O₆

Molecular weight: 259.22

Ref: 7W-GA1143

Mizoribine hydrobromide

CAS: 50924-49-7

Molecular weight: 259.22

Ref: 7W-GA5326

Mizoribine

CAS: 50924-49-7

Formula: C₉H₁₃N₃O₆

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 259.22

Ref: 3B-M2399

Mizoribine

CAS: 50924-49-7

Formula: C₉H₁₃N₃O₆

Molecular weight: 259.22

Ref: 4Z-M-335001

Mizoribine RS

CAS: 50924-49-7

Color and Shape: White To Pale Yellowish White Solid Crystalline Powder

Ref: 2K-1157000021

Mizoribine

CAS: 50924-49-7

Inhibitor of heat shock protein Hsp60; immunosuppressant

Formula: C₉H₁₃N₃O₆

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 259.22 g/mol

Ref: 3D-NM09731

Mizoribine

CAS: 50924-49-7

M05728 - Mizoribine

Formula: C₉H₁₃N₃O₆

Purity: 98%

Color and Shape: Solid, White - Very pale yellow powder

Molecular weight: 259.218

Ref: 10-M05728

Mizoribine

Controlled Product

CAS: 50924-49-7

Formula: C₉H₁₃N₃O₆

Color and Shape: Neat

Molecular weight: 259.22

Ref: TR-M385500

Mizoribine-13C2,15N

Controlled Product

CAS: 50924-49-7

Formula: C₂C₇H₁₃₁₅NN₂O₆

Color and Shape: Neat

Molecular weight: 262.195

Ref: TR-M385502